Division of Biochemistry, Biophysics and Structural Biology
Division of Biochemistry, Biophysics and Structural Biology - Structure of the human Ndc80 kinetochore complex around microtubules
Division of Neurobiology
Division of Neurobiology - Phosphorylation of mTOR in neurons in the striatum
Division of Immunology and Pathogenesis
Division of Immunology and Pathogenesis - Salmonella typhimurium growing within a macrophage
Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Genetics, Genomics and Development - Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Cell and Developmental Biology
Division of Cell and Developmental Biology - Impaired trafficking of Notch in neoplastic ESCRT mutant Drosophila cells

Recent News

Congratulations to MCB & Chemistry Professor Jennifer Doudna, who is one of five recipients of this year's Medal of Honor from the American Cancer Society! Medal of Honor recipients are "distinguished individuals who have made valuable contributions in the fight against cancer through basic research, clinical research and cancer control."

Professor Doudna joined four others in receiving the award at a ceremony today in Washington, DC: former Vice President Joe Biden, CRISPR co-inventor Emmanuelle Charpentier, geneticist Charis Eng, and cancer researcher Michael Thun.

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Two new publications from MCB Professor David Raulet and collaborators focus on the role of natural killer cells in anti-tumor responses. Natural killer cells are a type of white blood cell that have an important role in defending against virally infected cells and tumors.

The first, published in Journal of Clinical Investigation, demonstrated that checkpoint inhibitors, a well-established cancer immunotherapy, have the ability to activate natural killer cells. In the future, researchers hope to better understand the factors that influence natural killer cell activation for use in improved immunotherapies. Read more...

The second paper, published in Immunity, is a collaboration with the lab of MCB Professor Russell Vance. It shows that cGAMP from tumors promotes natural killer anti-tumor immune responses. Read more...

A new paper from the lab of Professor of MCB & Chemistry and HHMI Investigator Jennifer Doudna identifies and details the power of the smallest CRISPR system found to date, Cas14. CRISPR-Cas14 was first discovered in archaea with some of the smallest known genomes and is especially effective in editing viral genes or genes in small cells.

Due to its effectiveness in targeting and cutting single-stranded DNA, researchers have identified Cas14's potential use in improving rapid CRISPR diagnostic tests for ailments such as cancer and infectious diseases.

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A new paper by Professor of the Graduate School Bruce Ames, published in Proceedings of the National Academy of Science, argues that a set of vitamins and minerals that are lacking from many Americans' diets may be key to defending against many chronic diseases and promoting healthy aging.

The publication is the culmination of a decade of research completed at Children's Hospital Oakland Research Institute (CHORI) and "concludes that healthy aging can be extended by ingesting optimal levels of 30 known vitamins and essential minerals, and he suggests that these, along with 11 additional substances not currently classified as vitamins, should be recognized as essential 'longevity vitamins' because of their potential to extend a healthy life."

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MCB Professors and HHMI Investigators John Kuriyan and Barbara Meyer have been elected to the National Academy of Medicine, which recognizes researchers who have made major contributions to the advancement of medical sciences, health care, and public health.

Kuriyan has been recognizes for his work in understanding eukaryotic cell signaling regulation, and Meyer for her work on chromosome dynamics.

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