Beyond Sequence, Learning to Read Genomes
Adjunct Professor of Cell and Developmental Biology Gary Karpen and a team of researchers with the "model organism Encyclopedia of DNA Elements" (modENCODE) project have published a new analysis of the fruit fly genome in Science, Nature, and Genome Research that goes beyond the mere genetic sequence to reveal the RNA and chromatin structures that produce a functional organism.
Direction-selective neurons, which respond selectively to motion in one direction, have been characterized in visual circuits across many species. In the retina, it has been postulated that the ability to discern the direction of motion of an object required asymmetric wiring between the retinal neurons. However, the mechanisms that instruct this asymmetric wiring during development were completely unknown.