A team of researchers led by MCB Professor and HHMI Investigator Eva Nogales has successfully resolved the 3-D structure of transcription factor IIH (TFIIH) using cryo-electron microscopy at near atomic resolution.

This new technique allows structural biologists to visualize how specific molecules interact with target proteins in cells, and how protein mutations affect cell function.

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Credit: Basil Greber/Berkeley Lab and UC Berkeley