A major step in the development of the vertebrate embryo - the establishment of a back that morphs into a brain, spinal cord and muscles - turns out to be so important that the body uses at least three signals to make sure it happens properly.
The discovery, reported this month in the journal Developmental Cell by researchers at the University of California, Berkeley, finally explains an 80-year-old observation that revolutionized the way biologists think about embryonic and fetal development and set the stage for the stem cell debate.