The Molecular Basis of Cell Function (5T32GM007232-38) training program has a long-standing and defining principle: early and persistent emphasis on student training for an individually directed path to innovative research. The breadth of interests and interactions among the trainees and training grant faculty, combined with unique program requirements such as peer-group research presentations starting in the first year, encourage trainees to seek cross-disciplinary training opportunities. Another key tenet of the program is that the students share their knowledge by classroom teaching and participation in advanced seminar classes. The program is strongly committed to recruiting and training students from diverse personal backgrounds. The Molecular Basis of Cell Function is the only training grant specific to, and the only training grant largely comprehensive for, the MCB graduate program. Training grant faculty research spans the 5 administrative Divisions of the Department (Biochemistry and Molecular Biology/ Cell and Developmental Biology/ Genetics, Genomics, and Development/ Immunology and Pathogenesis/ Neurobiology).