We are excited to officially welcome new faculty member Srigokul ‘Gokul’ Upadhyayula to MCB! Upadyayula joins MCB as an Assistant Professor in Residence in the Division of Cell & Developmental Biology and is the first Scientific Director of the Advanced Bioimaging Center (ABC, formerly the Advanced Imaging Center) on campus.
Congratulations to Professor Emeritus Robert Glaeser on being awarded the 2019–20 Edward A. Dickson Emeriti Professorship!
This annual University of California award recognizes teaching, research, and public service. Glaeser is an international reference point for the physical and technical understanding of electron diffraction and imaging, as well as for his knowledge concerning biological radiation damage. Over the course of his career, he has mentored students and postdocs that have gone on to become leaders in the cryo-electron microscopy field.
New research from the labs of MCB Assistant Professor Roberto Zoncu & MCB, Chemistry, and NST Associate Professor Dan Nomura reveals a newly-discovered small-molecule activator of autophagy called EN6. This research, published in Nature Chemical Biology, reveals a unique approach for enhancing autophagy, which may have implications for the development of novel therapeutics in the future.
A new study co-authored by MCB Professor Gary Karpen describes how the human DNA in centromeres, the central areas of chromosomes, has survived largely unchanged for hundreds of thousands of years.
Because they do not participate in the “crossover” process that occurs when cells divide to form sperm or eggs, centromeres may preserve very ancient stretches of DNA. The researchers found that some DNA at our centromeres may have originated in populations of Neanderthals and ancestral hominids from before modern humans migrated out of Africa.
This research may also provide a way of better understanding the functional importance of chromosomal crossover in sexually-reproducing organisms.
A new study co-authored by MCB, Chemistry & NST Associate Professor Dan Nomura investigates how nimbolide, a natural product derived from the neem tree, may function in impairing cancer pathogenicity.
“We discover here that nimbolide not only impairs cancer pathogenicity through stabilizing tumor suppressors, but that we can exploit nimbolide to also degrade and eliminate other cancer-causing proteins in cells for cancer therapy,” said Nomura.
Congratulations to MCB Assistant Professor Michel Dupage, who was named a 2019 Pew-Stewart Scholar for Cancer Research! This prestigious honor for early-career researchers from Pew Research Center comes with multiyear research funding aimed at advancing human health.