Division of Immunology and Pathogenesis
Division of Immunology and Pathogenesis - Salmonella typhimurium growing within a macrophage
Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Genetics, Genomics and Development - Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Cell and Developmental Biology
Division of Cell and Developmental Biology - Impaired trafficking of Notch in neoplastic ESCRT mutant Drosophila cells
Division of Neurobiology
Division of Neurobiology - Phosphorylation of mTOR in neurons in the striatum
Division of Biochemistry, Biophysics and Structural Biology
Division of Biochemistry, Biophysics and Structural Biology - Structure of the human Ndc80 kinetochore complex around microtubules

Recent News

DNA

A new study co-authored by MCB Professor Gary Karpen describes how the human DNA in centromeres, the central areas of chromosomes, has survived largely unchanged for hundreds of thousands of years.

Because they do not participate in the “crossover” process that occurs when cells divide to form sperm or eggs, centromeres may preserve very ancient stretches of DNA. The researchers found that some DNA at our centromeres may have originated in populations of Neanderthals and ancestral hominids from before modern humans migrated out of Africa.

This research may also provide a way of better understanding the functional importance of chromosomal crossover in sexually-reproducing organisms.

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Congratulations to MCB Associate Professor Hillel Adesnik, and MCB Assistant Professors Gloria Brar and Stephen Brohawn on being named 2019 Rose Hills Innovators! 

The program, launched in 2014 and established with generous support from The Rose Hills Foundation, supports distinguished early-career faculty in the STEM fields.

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Nomura

A new study co-authored by MCB, Chemistry & NST Associate Professor Dan Nomura investigates how nimbolide, a natural product derived from the neem tree, may function in impairing cancer pathogenicity.

“We discover here that nimbolide not only impairs cancer pathogenicity through stabilizing tumor suppressors, but that we can exploit nimbolide to also degrade and eliminate other cancer-causing proteins in cells for cancer therapy,” said Nomura.

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DuPage

Congratulations to MCB Assistant Professor Michel Dupage, who was named a 2019 Pew-Stewart Scholar for Cancer Research! This prestigious honor for early-career researchers from Pew Research Center comes with multiyear research funding aimed at advancing human health.

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Doudna & Weissman

The pharmaceutical company GlaxoSmithKline (GSK) has announced a five-year collaboration with UC Berkeley and UCSF to establish the Laboratory for Genomics Research (LGR), where state-of-the-art CRISPR techniques will be used to advance the genomic research and rapidly accelerate new drug development.

“LGR is about building that space where creative science is partnered with the development of robust technology that will help develop tomorrow’s drugs. I think we’re going to be able to do science that none of us can even imagine today," said MCB & Chemistry Professor Jennifer Doudna, who will be a member of the LGR's steering committee.

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