Division of Immunology and Pathogenesis
Division of Immunology and Pathogenesis - Salmonella typhimurium growing within a macrophage
Division of Neurobiology
Division of Neurobiology - Phosphorylation of mTOR in neurons in the striatum
Division of Biochemistry, Biophysics and Structural Biology
Division of Biochemistry, Biophysics and Structural Biology - Structure of the human Ndc80 kinetochore complex around microtubules
Division of Cell and Developmental Biology
Division of Cell and Developmental Biology - Impaired trafficking of Notch in neoplastic ESCRT mutant Drosophila cells
Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Genetics, Genomics and Development - Heterochromatin dynamics in Saccharomyces cerevisiae

Recent News

New research from MCB Assistant Professor Stephan Lammel challenges the long-standing presumption that dopamine exists primarily as a reward in response to pleasurable stimuli. Instead, Lammel's findings indicate that dopamine has a "yin-yang" personality and is released in response to both pleasurable and displeasurable stimuli as a means of changing neural circuits. Those changes then train the brain to either pursue or avoid those stimuli.

This new understanding of the function of dopamine can lead to new approaches in treating certain neurological disorders affected by dopamine, such as Parkinson's and substance addiction.

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Congratulations to Hillel Adesnik, Xavier Darzacq, and Polina Lishko on their promotions to MCB Associate Professors!

Hillel Adesnik studies the dynamics of neural circuits underlying information processing in the cerebral cortex. His lab seeks to understand how cortical microcircuits process sensory information to drive behavior.

Xavier Darzacq studies transcription regulation during cellular differentiation. The Tjian-Darzacq group focuses on the role imposed by nuclear architecture on the molecules regulating transcription, and have developed new techniques to study the organization of proteins in the nucleoplasm.

Polina Lishko studies cell biology of mammalian fertilization. Her research on human sperm cell motility may lead to new forms of male contraceptives.

A new study from MCB Associate Professor & HHMI Investigator Andreas Martin reveals how proteasomes convert energy into mechanical motion to break down and recycle proteins. This research on the mechanism of proteasomes could improve treatment of diseases such as Parkinson's, Alzheimer's, and cancer.

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It is with great sadness we report the passing of Jack Kirsch, who served as a Professor of MCB and Chemistry from 1964 to 2006 and as a Professor of the Graduate School in retirement. Jack was an esteemed scientist and a pillar of the campus community who will be greatly missed by all who knew and worked with him.

Jack received the UC Berkeley Edward A. Dickson Emeriti Professorship in 2016, a prestigious award that recognizes dedicated Emeriti who have made outstanding and far-reaching contributions to teaching, research, and public service. The award epitomizes the remarkable impact Jack had on the Cal community, from his groundbreaking research career in the field of biochemistry to his passion for teaching a freshman seminar titled "Sampling the Performing Arts at Berkeley."

In this time of loss, we as a community must remember how fortunate we are to have been influenced by Jack's great legacy. We offer our condolences to Jack's family and close friends.

Read Jack's obituary here

New research published in Science by MCB Professor and HHMI Investigator Eva Nogales pushes the limits of cryo-electron microscopy with freeze-frames of TFIID, a critical gene transcription molecule. TFIID, or transcription factor IID, is a relatively large protein with a structure that had been difficult to capture prior to the research.

These more detailed images "could help drug designers create drugs that interfere with the molecule’s structural changes in order to tweak the expression of a gene that is causing disease."

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