Immunology and Pathogenesis

IMPFaculty of the Division of Immunology and Pathogenesis (I&P) conduct advanced research to understand the mouse and human immune system. Various division members are interested in the structure and function of cell surface receptors, the assembly of antigen receptor genes, and other aspects of immune recognition. In addition, we focus upon immune surveillance in cancer, apoptosis, tissue transplantation, autoimmunity and infectious disease. The faculty offers a cohesive program of training in modern molecular and cellular immunology that contributes to and benefits from its close ties to research in the allied fields of biochemistry, molecular and cell biology, cell biology and genetics being conducted in other Divisions. The Division, in conjunction with the Cancer Research Laboratory, supervises and maintains state-of-the-art instrumentation for advanced microscopy, flow cytometry, and the construction of transgenic and gene-targeted mice. 

A selection of papers published by MCB graduate students in IMP labs:

Chavarría-Smith J, Vance RE. (2015) The NLRP1 inflammasomes . Immunological reviews. 265(1):22-34.

Gowen BG, Chim B, Marceau CD, Greene TT, Burr P, et al. (2015) A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells. eLife. 4.

Newman ZR, Young ZJ, Ignolia N, Barton GM. (2016) Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9. Proceedings of the National Academy of Sciences of the United States of America.