Nogales: Pushing Limits of Cryo-EM on TFIID

New research published in Science by MCB Professor and HHMI Investigator Eva Nogales pushes the limits of cryo-electron microscopy with freeze-frames of TFIID, a critical gene transcription molecule. TFIID, or transcription factor IID, is a relatively large protein with a structure that had been difficult to capture prior to the research.

These more detailed images "could help drug designers create drugs that interfere with the molecule’s structural changes in order to tweak the expression of a gene that is causing disease."