Publications and Links (04'-present)


2004 2005
2006 2007 2008 2009 2010 2011 2012 2013
2014 2015 2016  2017            



Kerdiles, Y. M., F. F. Almeida, T. Thompson, M. Chopin, M. Vienne, P. Bruhns, N. D. Huntington, D. H. Raulet, S. L. Nutt, G. T. Belz, and E. Vivier. 2017. MICA-Expressing monocytes enhance natural killer cell Fc receptor-mediated antitumor functions. Immunity 47:199-200. 

Campbell, A. R., M. C. Duggan, L. P. Suarez-Kelly, N. Bhave, K. S. Opheim, E. L. McMichael, P. Trikha, R. Parihar, E. Luedke, A. Lewis, B. Yung, R. Lee, D. H. Raulet, S. Tridandapani, V. Groh, L. Yu, V. Yildiz, J. C. Byrd, M. A. Caligiuri, and W. E. Carson. 2017. MICA-Expressing monocytes enhance natural killer cell Fc receptor-mediated antitumor functions. Cancer Immunology 5:778-789. 

Vance, R. E., M. J. Eichberg, and D. H. Raulet. 2017. Listening to each other: Infectious disease and cancer immunology. Science Immunology 2. DOI: 10.1126/sciimunol.aai9339


Ardolino, M. and D. H. Raulet. 2016. Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors. Oncoimmunology 5:e1002725.

Iannello, A., T. W. Thompson, M. Ardolino, A. Marcus and D. H. Raulet. 2016. Immunosurveillance and immunotherapy of tumors by innate immune cells. Current opinion in immunology 38:52-58.

Clark, S. E., H. C. Filak, B. S. Guthrie, R. L. Schmidt, A. Jamieson, P. Merkel, V. Knight, C. M. Cole, D. H. Raulet and L. L. Lenz. 2016. Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection. PLoS Pathog 12:e1005708.

Shifrin, N., D. U. Kissiov, M. Ardolino, N. T. Joncker and D. H. Raulet. 2016. Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness. J Immunol. DOI: 10.4049/jimmunol.1402447

Spiegel, A., M. W. Brooks, S. Houshyar, F. Reinhardt, M. Ardolino, E. Fessler, M. B. Chen, J. A. Krall, J. DeCock, I. K. Zervantonakis, A. Iannello, Y. Iwamoto, V. Cortez-Retamozo, R. D. Kamm, M. J. Pittet, D. H. Raulet and R. A. Weinberg. 2016. Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells. Cancer discovery 6:630-649.


Karimi, M. A., J. L. Bryson, L. P. Richman, A. D. Fesnak, T. M. Leichner, A. Satake, R. H. Vonderheide, D. H. Raulet, R. Reshef and T. Kambayashi (2015). "NKG2D expression by CD8+ T-cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT." Blood.

Deng, W., B. G. Gowen, L. Zhang, L. Wang, S. Lau, A. Iannello, J. Xu, T. L. Rovis, N. Xiong and D. H. Raulet (2015). "A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection." Science. DOI: 10.1126/ science.1258867 

Gowen, B. G., B. Chim, C. D. Marceau, T. T. Greene, P. Burr, J. R. Gonzalez, C. R. Hesser, P. A. Dietzen, T. Russell, A. Iannello, L. Coscoy, C. L. Sentman, J. E. Carette, S. A. Muljo and D. H. Raulet. 2015. A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells. Elife 4:e08474.

Ardolino, M., J. Hsu and D. H. Raulet. 2015. Cytokine treatment in cancer immunotherapy. Oncotarget 6:19346-19347.

Raulet, D. H. 2015. Bone Marrow Cell Rejection, MHC, NK Cells, and Missing Self Recognition: Ain't That Peculiar (with Apologies to Marvin Gaye). J Immunol 195:2923-2925.


Ardolino, M., C. S. Azimi, A. Iannello, T. N. Trevino, L. Horan, L. Zhang, W. Deng, A. M. Ring, S. Fischer, K. C. Garcia and D. H. Raulet (2014). "Cytokine therapy reverses NK cell anergy in MHC-deficient tumors." The Journal of clinical investigation 124(11): 4781-4794.

Lam, A. R., N. Le Bert, S. S. Ho, Y. J. Shen, M. L. Tang, G. M. Xiong, J. L. Croxford, C. X. Koo, K. J. Ishii, S. Akira, D. H. Raulet and S. Gasser. 2014. RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma. Cancer Res 74:2193-2203.

Shifrin N, Raulet DH, Ardolino M. 2014. NK cell self tolerance, responsiveness, and missing self recognition. Seminars in immunology 26(2):138-44.

Marcus A, Gowen BG, Thompson TW, Ianello A, Ardolino M, Deng W, Wang L, Shifrin N, Raulet DH. 2014. Recognition of tumors by the innate immune system and natural killer cells.  Advances in immunology 122:91-128.

Iannello, A. and D. H. Raulet. 2014. Immunosurveillance of senescent cancer cells by natural killer cells. Oncoimmunology 3:e27616 


Guerra N, Pestal K, Juarez T, Beck J, Tkach K, Wang L, Raulet DH. 2013. A selective role of NKG2D in inflammatory and autoimmune diseases.  Clinical Immunology 149(3PB):432-39.

Marcus A, Raulet DH. 2013. A simple and effective method for differentiating GFP and YFP by flow cytometry using the violet laser. Cytometry. Part A: J of the International Society for Analytical Cytology 83(11):973-74.

Ianello A, Raulet DH. 2013. Immune Surveillance of Unhealthy Cells by Natural Killer Cells. Cold Spring Harbor symposia on quantitative biology.

Ianello A, Thompson TW, Ardolino M, Lowe SW, Raulet DH. 2013.  p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J Experimental Medicine 210(10):2057-69.

Marcus A, Raulet DH. 2013. Evidence for natural killer cell memory. Current Biology 23(17):R817-20.

Sheppard S, Triulzi C, Ardolino M, Serna D, Zhang L, Raulet DH, Guerra N. 2013. Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire.  Blood 121(25):5025-33.

Croxford JL1, Tang ML, Pan MF, Huang CW, Kamran N, Phua CM, Chng WJ, Ng SB, Raulet DH, Gasser S. 2013. ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cells. Blood 121 (13):2512-21

van Bergen J, Thompson A, van Pel M, Retiere C, Salvatori D, Raulet DH, Trowsdale J, Koning F. 2013. HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model. J Immunol 190(6): 2880-5

Raulet DH, Gasser S, Gowen BG, Weiwen D, Jung H. 2013. Regulation of ligands for the NKG2D activating receptor. Annu Rev Immunol 31:413-414.


Jung J, Hsiung B, Pestal K, Procyk E, Raulet DH. 2012. RAE-1 ligands for the NKG2D receptor are regulated by E2F-transcription factors, which control cell cycle entry. J Exp Med 209(13):2409-2422.

Coombes JL, Han SJ, van Rooijen N, Raulet DH, Robey EA. 2012. Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus. Cell rep 2(1):124-135.

Belanger S, Tu MM, Rahim MM, Mahmoud AB, Patel R, Tai L, Troke AD, Wilhelm BT, Landry JR, Zhu Q, Tung KS, Raulet DH, Makrigiannis AP. 2012. Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice. Blood 120(3):592-602.

Wortham BW, Eppert BL, Motz GT, Flury JL, Orozco-Levi M, Hoebe K, Panos RJ, Maxfield M, Glasser SW, Senft AP, Raulet DH, Borchers MT. 2012. NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol 188(9):4468-4475.


 Xia M, Guerra N, Sukjova GK, Yang K, Miller CK, Shi G, Raulet DH, and Xiong N. 2011. Immune Activation Resulting From NKG2D/Ligand Interaction Promotes Atherosclerosis. Circulation.

Vivier, E., D.H. Raulet, A. Moretta, M.A. Caligiuri, L. Zitvogel, L.L. Lanier, W.M. Yokoyama and S. Ugolini. 2011. Innate or adaptive immunity? The example of natural killer cells. Science 331:44-49.

Tokuyama, M., C. Lorin, F. Delebecque, H. Jung, D. H. Raulet and L. Coscoy. 2011. Expression of the RAE-1 Family of Stimulatory NK-Cell Ligands Requires Activation of the PI3K Pathway during Viral Infection and Transformation. PLoS Pathog 7:e1002265.


Blanchard, N., T. Kanaseki, H. Escobar, F. Delebecque, N.A. Nagarajan, E. Reyes-Vargas, D.K. Crockett, D.H. Raulet, J.C. Delgado and N. Shastri. 2010. Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells. J Immunol 184:3033-3042.

Fine, J.H., P. Chen, A. Mesci, D.S. Allan, S. Gasser, D.H. Raulet and J.R. Carlyle. 2010. Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missing-self recognition. Cancer Res 70:7102-7113.

Nice, T.J., W. Deng, L. Coscoy and D.H. Raulet. 2010. Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase. J Immunol 185:5369-5376.

Joncker, N.T., N. Shifrin, F. Delebecque and D.H. Raulet. 2010. Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment. J Exp Med 207:2065-2072.


Uche, U. N., C. R. Huber, D. H. Raulet and N. Xiong. 2009. Recombination Signal Sequence-Associated Restriction on TCRdelta Gene Rearrangement Affects the Development of Tissue-Specific gammadelta T Cells. J Immunol 183:4931-4939.

Raulet, D. H. and N. Guerra. 2009. Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat Rev Immunol 9:568-580.

Raulet, D. H. 2009. Natural Killer Cells: Remembrances of Things Past. Curr Biol 19:R294-296.

Joncker, N. T., N. C. Fernandez, E. Treiner, E. Vivier and D. H. Raulet. 2009. NK Cell Responsiveness Is Tuned Commensurate with the Number of Inhibitory Receptors for Self-MHC Class I: The Rheostat Model. Immunol 182:4572-4580.

Whang, M. I., N. Guerra and D. H. Raulet. 2009. Costimulation of Dendritic Epidermal gamma-delta T Cells by a New NKG2D Ligand Expressed Specifically in the Skin. J Immunol 182:4557-4564.

Nice TJ, Coscoy L, Raulet DH. 2009. Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress. J Exp Med 206:287-298.

Kawamura, T, K. Takeda, H. Kaneda, H. Matsumoto, Y. Hayakawa, D. H. Raulet, Y. Ikarashi, M. Kronenberg, H. Yagita, K. Kinoshita, T. Abo, K. Okumura, and M. J. Smyth. 2009. NKG2A inhibits iNKT cell activation in hepatic injury. J. Immunol 182(1):250-8.

Raulet, D. 2009. Disarming of autoreactive NK cells. Natural Killer Cell Biology: Natural killer cell-mediated immunity to pathogens and cancer, The Biomedical & Life Sciences Collection: (online at


Xiong N, Zhang L, Kang C, Raulet DH. 2008. Gene placement and competition control T cell receptor gamma variable region gene rearrangement. J Exp Med 205(4):929-38.

Guerra N, Tan YX, Joncker NT, Choy A, Gallardo F, Xiong N, Knoblaugh S, Cado D, Greenberg NM, Raulet DH. 2008. NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity 28(4):571-80.

Joncker, N.T. and Raulet, D. H. 2008. Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells. Immunol Rev 224:85-97.


Coscoy, L., and D. H. Raulet. 2007. DNA mismanagement leads to immune system oversight. Cell 131(5):836-8 .

Pinto, A. K., A. M. Jamieson, D. H. Raulet, and A. B. Hill. 2007. The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J. Viro 81:12564-12571 .

Roth, C., C. Rothlin, S. Riou, D. H. Raulet, and G. Lemke. 2007. Stromal-cell regulation of natural killer cell differentiation. J Mol Med 85:1047-56.

Arina, A., O. Murillo, S. Hervas-Stubbs, A. Azpilikueta, J. Dubrot, I. Tirapu, E. Huarte, C. Alfaro, J. L. Perez-Gracia, G. Gonzalez-Aseguinolaza, P. Sarobe, J. J. Lasarte, A. Jamieson, J. Prieto, D. H. Raulet, and I. Melero. 2007. The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFNgamma. Int J Cancer 121(6): 1282-195.

Cavanaugh, V. J., D. H. Raulet, and A. E. Campbell. 2007. Upregulation of CD94/NKG2A receptors and Qa-1b ligand during murine cytomegalovirus infection of salivary glands. J Gen Virol 88:1440-1445.

Xiong, N.and D.H. Raulet. 2007. Development and selection of gammadelta T cells. Immunol Rev 215:15-31


Gasser, S., and D.H. Raulet. 2006. The DNA damage response, immunity and cancer. Semin Cancer Biol 16:344-377.

Gasser, S. and D. H. Raulet. 2006. Activation and self-tolerance of natural killer cells. Immunol Rev 214:130-142.

Caraux, A., Q. Lu, N. Fernandez, S. Riou, J.P. Di Santo, D.H. Raulet, G. Lemke, and C. Roth. 2006. Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol 7:747-754. 

Raulet, D.H., and R.E. Vance. 2006. Self-tolerance of natural killer cells. Nat Rev Immunol 6:520-531.

Raulet, D.H. 2006. Missing self recognition and self tolerance of natural killer (NK) cells. Semin Immunol 3:145-150.

Gasser, S., and D.H. Raulet. 2006. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptorarouses the immune system. Cancer Research 66(8):3959-62.

Chiesa, S., M. Mingueneau, N. Fuseri, B. Malissen, D.H. Raulet, M. Malissen, E. Vivier, and E. Tomasello. 2006. Multiplicity and plasticity of natural killer cell signaling pathways. Blood 107(6):2364-72.


Orr M.T., K.H. Edelmann, J. Vieira, L. Corey, D.H. Raulet, and C.B. Wilson. 2005. Inhibition of MHC class I is a virulence factor in herpes simplex virus infection of mice. PLoS Pathog 1(1):e7.

Gasser, S., S. Orsulic, E.J. Brown, and D.H. Raulet. 2005. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436(7054):1186-1190.

Kawamura, H., H. Yagita, T. Nisizawa, N. Izumi, C. Miyaji, R.E. Vance, D.H. Raulet, K. Okumura, and T. Abo. 2005. Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells. Eur J Immunol. 35(8):2358-2366.

Ota, T., K. Takeda, H. Akiba, Y. Hayakawa, K. Ogasawara, Y. Ikarashi, S. Miyake, H. Wakasugi, T. Yamamura, M. Kronenberg, D.H. Raulet, K. Kinoshita, H. Yagita, M.J. Smyth, and K. Okumura. 2005. IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2. Blood 106(1):184-192.

Fernandez, N.C., E. Treiner, R.E. Vance, A.M. Jamieson, S. Lemieux, and D.H. Raulet. 2005. A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 105(11):4416-4423


Bach, J.F., A. Bendelac, M.B. Brenner, H. Cantor, G. De Libero, M. Kronenberg, L.L. Lanier, D.H. Raulet, M.J. Shlomchik, and M.G. von Herrath. 2004. The role of innate immunity in autoimmunity. J Exp Med 200 (12):1527-1531.

Raulet, D.H. 2004. Interplay of natural killer cells and their receptors with the adaptive immune response. Nat Rev Immunol 5:996-1002.

Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B. 2004. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21:357-366. 

Anfossi, N., S.H. Robbins, S. Ugolini, P. Georgel, K. Hoebe, C. Bouneaud, C. Ronet, A. Kaser, C.B. DiCioccio||, E. Tomasello, R.S. Blumberg, B. Beutler, S. Reiner, L. Alexopoulou, O. Lantz, D.H. Raulet, L. Brossay, and E. Vivier. 2004. Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol 173:3773-3782. 

Xiong, N., C. Kang, and D.H. Raulet. 2004. Positive selection of dendritic epidermal gd T cell precursors in the fetal thymus determines expression of skin-homing receptors. Immunity 21:121-131.

Gold, M.C., M.W. Munks, M. Wagner, C.W. McMahon, A. Kelly, D.G. Kavanagh, M.K. Slifka, U.H. Koszinowski, D.H. Raulet, and A.B. Hill. 2004. Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response. J Immunol 172:6944-6953. 

Andre, P., R. Castriconi, M. Espeli, N. Anfossi, T. Juarez, S. Hue, H. Conway, F. Romagne, A. Dondero, M. Nanni, S. Caillat-Zucman, D.H. Raulet, C. Bottino, E. Vivier, A. Moretta, and P. Paul. 2004. Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur J Immunol 34:961-971.

Carlyle, J.R., A.M. Jamieson, S. Gasser, C.S. Clingan, H. Arase, and D.H. Raulet. 2004. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci USA 101:3527-3532.

Tanamachi, D.M., D.C. Moniot, D. Cado, S.D. Liu, J.K. Hsia, and D.H. Raulet. 2004. Genomic Ly49A transgenes: basis of variegated Ly49A gene expression and identification of a critical regulatory element. J Immunol 172:1074-1082.

Jamieson, A.M., P. Isnard, J.R. Dorfman, M.C. Coles, and D.H. Raulet. 2004. Turnover and proliferation of NK cells in steady state and lymphopenic conditions. J Immunol 172:864-870.

Xiong, N., J.E. Baker, C. Kang, and D.H. Raulet. 2004. The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern. Proc Natl Acad Sci USA 101:260-265..