Faculty and Research
Faculty by Name
Daniel Koshland
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Daniel Koshland
Research Interests
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Our research is directed towards structure-function relationships in receptors and bioengineering of novel proteins. Enzymes and receptors are being modified to change specificity and design new catalysts.
Structure-function relationships. We are changing the specificity of enzymes and improving catalytic power as a device to engineer new proteins for therapy and waste disposal purposes.
Neurobiological applications. We are applying genetic engineering and protein chemistry to designing therapies for Alzheimer's Disease.
Selected Publications
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Propagating Conformational Changes over long (and short) Distances. [E. Yu, D.E. Koshland Jr. (2001) PNAS, in press]
Structure Basis for a Change in Substrate Specificity. [S. Doyle, P. Beernink, D.E. Koshland Jr. (2001) Biochemistry 40, 4234]
A new model for protein sterospecificity. [A.D. Mesecar, D.E. Koshland Jr. (2000) Nature 403, 614-615]
A Piston Model for Transmembrane Signaling of the Aspartate Receptor. [K.M. Otteman, W. Xiao, Y-K, Shin, D.E. Koshland Jr. (1999) Science 285, 1751-1753]
Last Updated 2003-09-05