A team of researchers led by MCB Associate Professor David Savage has designed a novel protein engineering method known as MISER, which slims down the CRISPR-Cas9 protein.

A standard Cas9 protein is composed of 1,368 amino acids and is too large for many biomedical applications. By reducing the size of Cas9 proteins without sacrificing their core features, Savage and his team hope to pave the way to even more CRISPR-based therapies in the future.


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