Key DNA Protein Complex Mapped at Near-Atomic Resolution

A team of researchers led by MCB Professor and HHMI Investigator Eva Nogales has successfully resolved the 3-D structure of transcription factor IIH (TFIIH) using cryo-electron microscopy at near atomic resolution.

This new technique allows structural biologists to visualize how specific molecules interact with target proteins in cells, and how protein mutations affect cell function.


Credit: Basil Greber/Berkeley Lab and UC Berkeley