Syllabus – MCB 140,
Fall 2008
|
Month |
Day |
Date |
Topic |
Professor |
Misc |
|
Aug |
W |
27 |
Genetics - scope and
problems: |
FDU |
Required reading: Heredity
before genetics -- a history |
|
|
F |
29 |
Mendel - approach, 1st
law |
FDU |
Experiments
in plant hybridization -- Gregor Mendel Ch.2 in
textbook |
|
Sep |
M |
1 |
Labor Day |
|
|
|
|
W |
3 |
Mendel II - 2nd law |
FDU |
Office hours in the
auditorium right after class (ie, noon to 1 pm) Problems: 2.7, 2.9,
2.12, 2.18, 2.21 |
|
|
F |
5 |
Chromosomes 1: Wilson,
Boveri, Sutton |
FDU |
Ch. 4 in textbook – commit Table 4.4 to memory. Fig. 4.18
and 4.19. |
|
|
M |
8 |
Chromosomes 2: Morgan,
Bridges |
FDU |
Fig. 4.20 and 4.21 TH
Morgan -- Sex Limited Inheritance in Drosophila TH
Morgan et al -- Mechanisms of Mendelian inheritance, ch 1 Everything to do with Fig. 14.32. TH
Morgan et al -- Mechanisms of Mendelian inheritance, ch 6 |
|
|
W |
10 |
Chromosomes 3:
linkage; Sturtevant |
FDU |
In Ch. 5, focus on the
following figures: 5.2, 5.3, 5.6-5.8 (in section 1); pp. 135-140, esp. Fig.
5.10. TH
Morgan et al -- Mechanisms of Mendelian inheritance, ch 3 TH
Morgan et al -- Mechanisms of Mendelian inheritance, ch 5 Chs. 5-8 in
Alfred Sturtevant's book on the history of genetics |
|
|
F |
12 |
Chromosomes 4: changes
in chromosome number |
GG |
|
|
|
M |
15 |
Beyond Mendel: allelic
series, epistasis, expressivity, penetrance, norm of reaction |
FDU |
Quiz 1 this week Chapter 3 |
|
|
W |
17 |
Topic ctd |
FDU |
Office hours after
class outside of Morgan Hall |
|
|
F |
19 |
Microbial genetics:
Luria/Delbruck; Beadle/Tatum; Lederberg; Hayes |
FDU |
Fig. 7.4 and 7.23. Ch. 15 |
|
|
M |
22 |
The recombinant DNA
“controversy”; genetic engineering |
FDU |
|
|
|
W |
24 |
Topic ctd |
FDU |
|
|
|
Th |
25 |
Review session |
FDU |
McCone 141, 6 – 9 pm |
|
|
F |
26 |
Plant genetics and
epigenetics |
FDU |
|
|
|
M |
29 |
Epigenetics –
ctd – note new handout |
FDU |
|
|
Oct |
W |
1 |
Midterm 1 |
|
6:30-9:00 145 Dwinelle |
|
|
F |
3 |
GG |
|
|
|
|
M |
6 |
GG |
|
|
|
|
W |
8 |
topic continued |
GG |
|
|
|
F |
10 |
GG |
|
|
|
|
M |
13 |
GG |
|
|
|
|
W |
15 |
GG |
|
|
|
|
F |
17 |
Genetic analysis of
mutation types (PDF) |
GG |
|
|
|
M |
20 |
Mosaic analysis (PDF)
(revised) |
GG |
Quiz 2 this week |
|
|
W |
22 |
GG |
|
|
|
|
F |
24 |
GG |
|
|
|
|
M |
27 |
GG |
|
|
|
|
W |
29 |
GG |
|
|
|
|
F |
31 |
GG |
||
|
Nov |
M |
3 |
Functional genomics
with RNAi |
FDU |
|
|
|
W |
5 |
Midterm 2
|
|
6:30 9:00 105 North Gate |
|
|
F |
7 |
Qualitative
linkage I |
RB |
Review pp. 124-141.
Read pp. 394-423 and http://www.informatics.jax.org/silver/frames/frame10-2.shtml,
section 10.2. Do problems Ch.
11: I, II, 2, 4, 20. Also do problem II in Ch. 19. |
|
|
M |
10 |
Qualitative
linkage 2 |
RB |
Read http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hmg.section.1412,
11.3.1 and 11.3.2. Also problem set 1. Here are the answers. |
|
|
W |
12 |
When to
believe a p-value? |
RB |
|
|
|
F |
14 |
Complex
traits and quantitative traits I |
RB |
Review pp. 56-71. |
|
|
M |
17 |
Quantitative
traits 2 |
RB |
Read pp. 773-778.
Do problems Ch. 21: 25,
27, 29. Also problem set 2. Here are
the answers. |
|
|
W |
19 |
Quantitative
traits 3 |
RB |
|
|
|
F |
21 |
Molecular
genetics |
RB |
Read pp. 335-339.
Do problems Ch. 7: 32 and
33, and Ch. 11: 26 and 27. |
|
|
M |
24 |
Epistasis
and mapping HTG in pathogenic yeast |
RB |
|
|
|
W |
26 |
Mapping
the golden locus |
RB |
|
|
|
F |
28 |
Thanksgiving |
|
|
|
Dec |
M |
1 |
Association
mapping |
RB |
Read pp. 423-424.
Do problems Ch. 11: 31
and 32. Also problem set 3.
Here are the answers
(revised). |
|
|
W |
3 |
Association
2 |
RB |
|
|
|
F |
5 |
Natural
variation in gene expression |
RB |
|
|
|
M |
8 |
Natural
variation in gene expression 2 |
RB |
|
|
|
W |
10 |
Cryptic
variation |
RB |
Final
spring 07; answers
(revised) |
|
|
Sat |
13 |
Final |
|
1230-330P |
|
|
|
|
|
|