Notable Publications

Brown KS, Blower MD, Maresca TJ, Grammer TC, Harland RM, Heald R. (2007) Xenopus tropicalis extracts provide insight into scaling of the mitotic spindle.  J. Cell Biol., 176, 765-770.

Heald R. (2007) Brinkley-Fest of Mitosis.  Dev. Cell 13, 168-176.

Yan J, Maresca T, Skoko D, Adams CD, Xiao B, Christensen M, Heald R, Marko JF.  (2007) Micromanipulation studies of chromatin fibers in Xenopus egg extracts reveal ATP-dependent nucleosome assembly dynamics.  Mol. Biol. Cell 18, 464-474.

Hannak E, Heald R.  (2007) Investigating mitotic spindle assembly in vitro using Xenopus egg extracts.  Nature Protocols 1, 2305-2314.

Deehan-Kenney R, Heald R. (2006) Essential roles for cohesin in kinetochore and spindle function in Xenopus egg extracts.  J. Cell Sci., 119, 5057-5066.

Kalab P, Pralle A, Isacoff EY, Heald R, Weis K. (2006) Analysis of a RanGTP-regulated gradient essential for mitosis in somatic cells. Nature 440, 607-701.

Heald R. (2006) Cell biology: Serving up a plate of chromosomes. Science 311, 343-344.

Hannak E, Heald R. (2006) Xorbit/CLASP links dynamic microtubules to chromosomes in the Xenopus meiotic spindle. J. Cell Biol. 172, 19-25.

Soderholm J, Uehara-Bingen M, Weis K, Heald R. (2006) Challenges facing the biologist doing chemical genetics. Nat. Chem. Biol. 2, 55-58.

Maresca TJ, Heald R. (2006) The long and the short of it: linker histone H1 is required for metaphase chromosome compaction.  Cell Cycle 5, 589-91.

Maresca TJ, Heald R. (2006) Methods for studying spindle assembly and chromosome condensation in Xenopus egg extracts. Methods in Molecular Biology 322, 459-474.

Maresca TJ, Niederstrasser H, Weis K, Heald R. (2005) Xnf7 contributes to spindle integrity through its microtubule bundling activity.  Curr. Biol. 15, 1755-61.

Maresca TJ, Heald R. (2005) Chromosome congression: another fine mesh we’ve gotten into. Dev. Cell 9, 314-315.

Maresca TJ, Freedman BS, Heald R. (2005) Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus egg extracts. J. Cell Biol. 169, 859-869.

Van Hooser A, Heald R. (2005) The perichromosomal layer. Chromosoma, 114, 377-388.

Blower MD, Nachury M, Heald R, Weis K. (2005) A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell 121,223-34.

Soderholm J, Heald R. (2005) Scratch ‘n screen for inhibitors of cell migration. Chem. Biol. 12, 263-265.

Banks JD, Heald R. (2004) Adenomatous Polyposis Coli Associates with the Microtubule-Destabilizing Protein XMCAK. Curr Biol. 14, 2033-8.

Gadde S, Heald R. (2004) Mechanisms and molecules of the mitotic spindle. Curr Biol. 14, R797-805.

Deehan R, Heald R. (2004) Centromere glue provides spindle cue. Cell 118, 529-30.

Skop AR, Liu H, Yates J 3rd, Meyer BJ, Heald R. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305, 61-6.

Wignall SM, Gray NS, Chang YT, Juarez L, Jacob R, Burlingame A, Schultz PG, Heald R. (2004) Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol 11, 135-46.

Krauss SW, Lee G, Chasis JA, Mohandas N, Heald R. (2004) Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro. J Biol Chem. 279, 27591-8.

Budde PP, Heald R. (2003) Centrosomes and kinetochores, who needs 'em? The role of noncentromeric chromatin in spindle assembly. Curr Top Dev Biol. 56, 85-113.

Wignall SM, Heald R. (2003) The role of chromosome architecture in spindle assembly and anaphase: the condensed version. Cell Cycle 2, 590-1.

Krauss SW, Chen C, Penman S, Heald R. (2003) Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro. Proc Natl Acad Sci U S A. 100, 10752-7.

Wignall SM, Deehan R, Maresca TJ, Heald R. (2003) The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts. J Cell Biol. 161, 1041-51.

Kalab P, Weis K, Heald R. (2002) Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 295, 2452-6.

Wignall SM, Heald R. Methods for the study of centrosome-independent spindle assembly in Xenopus extracts. Methods Cell Biol. 2001;67:241-56.

Budde PP, Kumagai A, Dunphy WG, Heald R. (2001) Regulation of Op18 during spindle assembly in Xenopus egg extracts. J Cell Biol. 153, 149-58.

Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K. (2001) Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell 104, 95-106.

Merdes A, Heald R, Samejima K, Earnshaw WC, Cleveland DW. (2000) Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J Cell Biol. 149, 851-62.

Rosania GR, Merlie J Jr, Gray N, Chang YT, Schultz PG, Heald R. (1999) A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc Natl Acad Sci U S A. 96, 4797-802.

Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R. (1998) A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr Biol. 8, 903-13.

Heald R, Tournebize R, Habermann A, Karsenti E, Hyman A. (1997) Spindle assembly in Xenopus egg extracts: respective roles of centrosomes and microtubule self-organization. J Cell Biol. 138, 615-28.

Heald R, Tournebize R, Blank T, Sandaltzopoulos R, Becker P, Hyman A, Karsenti E. (1996) Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature 382, 420-5.