Updated list of publications at this link:





Melichar HJ, Ross JO, Herzmark P, Hogquist KA, Robey EA.

Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ.

Sci Signal. 2013 Oct 15;6(297):ra92. doi: 10.1126/scisignal.2004400. 

Ingram WM, Goodrich LM, Robey EA, Eisen MB.
Mice Infected with Low-Virulence Strains of Toxoplasma gondii Lose Their Innate Aversion to Cat Urine, Even after Extensive               Parasite Clearance.
PLoS One. 2013 Sep 18;8(9):e75246. doi: 10.1371/journal.pone.0075246. 

Feliu V, Vasseur V, Grover HS, Chu HH, Brown MJ, Wang J, Boyle JP,Robey EA, Shastri N, Blanchard N

Location of the CD8 T Cell Epitope within the Antigenic Precursor Determines Immunogenicity and Protection against the Toxoplasma gondii Parasite.

PLoS Pathog. 2013 Jun;9(6):e1003449.


Dzhagalov IL, Chen KG, Herzmark P, Robey EA.

Elimination of self-reactive T cells in the thymus: a timeline for negative selection

PLoS Biol. 2013 May;11(5).


Coombes JL, Charsar BA, Han SJ, Halkias J, Chan SW, Koshy AA, Striepen B, Robey EA.

Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential for parasite spread.

Proc Natl Acad Sci USA. 2013 May 21;110(21):E1913-22.


Halkias J, Melichar HJ, Taylor KT, Ross JO, Yen B, Cooper SB, Winoto A, Robey EA.

Opposing chemokine gradients control human thymocyte migration in situ

J Clin Invest. 2013 May 1;123(5):2131-42. 




Coombes JL, Han SJ, van Rooijen N, Raulet DH, Robey EA.

Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus.

Cell Rep. 2012 Jul 26;2(1):124-35. Epub 2012 Jul 5.


Grover HS, Blanchard N, Gonzalez F, Chan S, Robey EA, Shastri N.

The toxoplasma gondii peptide AS15 elicits CD4 T cells that can control parasite burden.

Infect Immun. 2012 Sep;80(9):3279-88.


Germain RN, Robey EA, Cahalan MD.

A decade of imaging cellular motility and interaction dynamics in the immune system.

Science. 2012 Jun 29;336(6089):1676-81. Review.


Dzhagalov IL, Melichar HJ, Ross JO, Herzmark P, Robey EA.

Two-photon imaging of the immune system.

Curr Protoc Cytom. 2012; Apr; Chapter12: Unit12.26.




Tam C, Ledue J, Mun JJ, Herzmark P, Robey EA, Evans DJ, Fleiszig SM.

3D Quantitative Imaging of Unprocessed Live Tissue Reveals Epithelial Defense against Bacterial Adhesion and Subsequent

Traversal Requires MyD88.

PLoS One. 2011;6(8):e24008. Epub 2011 Aug 25.


Melichar HJ, Li O, Herzmark P, Padmanabhan RK, Oliaro J, Ludford-Menting MJ, Bousso P, Russell SM, Roysam B, Robey EA.

Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues.

Immunol Cell Biol. 2011 May; 89(4):549-57. 


Melichar H, Li O, Ross J, Haber H, Cado D, Nolla H, Robey EA, Winoto A.

Comparative study of hematopoietic differentiation between human embryonic stem cell lines.

PLoS One. 2011;6(5):e19854.




Osborn SL, Diehl G, Han SJ, Xue L, Kurd N, Hsieh K, Cado D, Robey EA, Winoto A.

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis.

Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13034-9.


Dzhagalov I, Robey EA.

Multitasking in the medulla.

Nat Immunol. 2010 Jun; 11(6):461-2.


Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A.

Regulation of thymocyte positive selection and motility by GIT2.

Nat Immunol. 2010 Jun; 11(6):503-11.


Coombes JL, Robey EA.

Dynamic imaging of host-pathogen interactions in vivo.

Nat Rev Immunol. 2010 May; 10(5):353-64. Review.


Azar GA, Lemaître F, Robey EA, Bousso P.

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3675-80. 




Chtanova T, Han SJ, Schaeffer M, van Dooren GG, Herzmark P, Striepen B, Robey EA.

Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node.

Immunity. 2009 Aug 21;31(2):342-55.


Le Borgne M, Ladi E, Dzhagalov I, Herzmark P, Liao YF, Chakraborty AK, Robey EA.

The impact of negative selection on thymocyte migration in the medulla.

Nat Immunol. 2009 Aug;10(8):823-30. 


Schaeffer M, Han SJ, Chtanova T, van Dooren GG, Herzmark P, Chen Y, Roysam B, Striepen B, Robey EA.

Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii.

J Immunol. 2009 May 15;182(10):6379-93.


Chen Y, Ladi E, Herzmark P, Robey E, Roysam B. 

Automated 5-D analysis of cell migration and interaction in the thymic cortex from time-lapse sequences of 3-D multi-channel

multi-photon images. 

J Immunol Methods. 2009 Jan 1;340(1):65-80.




Ladi E, Schwickert TA, Chtanova T, Chen Y, Herzmark P, Yin X, Aaron H, Chan SW, Lipp M, Roysam B, Robey EA.

Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex.

J Immunol. 2008 Nov 15;181(10):7014-23.


Chtanova T, Schaeffer M, Han SJ, van Dooren GG, Nollmann M, Herzmark P, Chan SW, Satija H, Camfield K, Aaron H,                

Striepen B, Robey EA.

Dynamics of neutrophil migration in lymph nodes during infection.

Immunity. 2008 Sep 19;29(3):487-96. Erratum in: Immunity. 2008 Oct;29(4):661.


Blanchard N, Gonzalez F, Schaeffer M, Joncker NT, Cheng T, Shastri AJ, Robey EA, Shastri N.

Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.

Nat Immunol. 2008 Aug;9(8):937-44. 


Ladi E, Herzmark P, Robey E. 

In situ imaging of the mouse thymus using 2-photon microscopy. 

J Vis Exp. 2008 Jan 25;(11). pii: 652. doi: 103791/652 




Yin X, Ladi E, Chan SW, Li O, Killeen N, Kappes DJ, Robey EA.

CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision.

J Immunol. 2007 Dec 1;179(11):7358-64.




Yin X, Chtanova T, Ladi E, Robey EA.

Thymocyte motility: mutants, movies and migration patterns.

Curr Opin Immunol. 2006 Apr;18(2):191-7. Review.


Ladi E, Yin X, Chtanova T, Robey EA.

Thymic microenvironments for T cell differentiation and selection.

Nat Immunol. 2006 Apr;7(4):338-43. Review.




Manilay JO, Anderson AC, Kang C, Robey EA.

Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1.

J Immunol. 2005 Jun 1;174(11):6732-41.


Witt CM, Raychaudhuri S, Schaefer B, Chakraborty AK, Robey EA.

Directed migration of positively selected thymocytes visualized in real time.

PLoS Biol. 2005 Jun;3(6):e160. Erratum in: PLoS Biol. 2005 Oct;3(10):e373 


Robey E.

The alphabeta versus gammadelta T cell fate decision: when less is more.

Immunity. 2005 May;22(5):533-4.


Robey EA.

Immunology: guide for a cell-fate decision.

Nature. 2005 Feb 24;433(7028):813-4.


Gubbels MJ, Striepen B, Shastri N, Turkoz M, Robey EA.

Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii.

Infect Immun. 2005 Feb;73(2):703-11.


Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G.

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.

Mol Biol Cell. 2005 Feb;16(2):927-42.


Witt CM, Robey EA.

Thymopoiesis in 4 dimensions.

Semin Immunol. 2005 Feb;17(1):95-102. Review.


Anderson AC, Kitchens EA, Chan SW, St Hill C, Jan YN, Zhong W, Robey EA.

The Notch regulator Numb links the Notch and TCR signaling pathways.

J Immunol. 2005 Jan 15;174(2):890-7.




Delaire S, Huang YH, Chan SW, Robey EA.

Dynamic repositioning of CD4 and CD8 genes during T cell development.

J Exp Med. 2004 Dec 6;200(11):1427-35.


Bousso P, Robey EA.

Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy.

Immunity. 2004 Sep;21(3):349-55. Review.


Witt CM, Robey EA.

The ins and outs of CCR7 in the thymus.

J Exp Med. 2004 Aug 16;200(4):405-9.


Robey EA, Bluestone JA.

Notch signaling in lymphocyte development and function.

Curr Opin Immunol. 2004 Jun;16(3):360-6. Review.


Huang YH, Li D, Winoto A, Robey EA.

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4936-41.


2003 - 2002


Robey EA, Bousso P.

Visualizing thymocyte motility using 2-photon microscopy.

Immunol Rev. 2003 Oct;195:51-7. Review.


Bousso P, Robey E.

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes. 

Nat Immunol.  2003 Jun;4(6):579-85.


Robey E, Schlissel M.

Lymphocyte development. 

Curr Opin Immunol. 2003 Apr; 15(2):155-7.


Fowlkes BJ, Robey EA.

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development.

J Immunol. 2002 Aug 15;169(4):1817-21.


Bousso P, Bhakta NR, Lewis RS, Robey E.

Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.  

Science. 2002 Jun 7;296(5574):1876-80.


2001 - 2000


Anderson AC, Robey EA, Huang YH.

Notch signaling in lymphocyte development.

Curr Opin Genet Dev. 2001 Oct;11(5):554-60. Review.


Chang, D., Valdez, P., Ho, T. and  Robey, E.

MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment. 

Journal of Immunology. 2000; 165: 6710-6715.


Itano, A. and  Robey, E.

Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment.

Immunity. 2000; 12: 383-389.


Valdez, P. and  Robey, E.

Notch and the CD4 versus CD8 lineage decision.

CSHSQB. 2000; 64. 


1999 - 1995


Salmon, P., Mong, M., Kang, X. J., Cado, D. and  Robey, E.

The role of CD8 alpha' in the CD4 versus CD8 lineage choice.

J Immunol. 1999;163, 5312-8.

Irie, H.Y., M. Mong, A. Itano, M. Crooks, D. Littman, S.J. Burakoff, and E. Robey.

The cytoplasmic domain of CD8 alpha regulates Lck kinase activation and CD8 T cell development.

Journal of Immunology. 1998; 161:1, 183-191 


Washburn T, Schweighoffer E, Gridley T, Chang D, Fowlkes B, Cado D, Salmon P, Robey E.

Notch activity influences the alpha/beta versus gamma/delta T cell lineage decision.

Cell. 1997; 88(6):833-843.


Robey, E, D Chang, A Itano, D Cado, H Alexander, D Lans, G Weinmaster and P Salmon.

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages.

Cell. 1996; 87(3):483-492


Itano, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella and  E. Robey.

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

Journal of Experimental Medicine. 1996; 183 : 731.


1994 - 1990


Robey EA.

The effect of constitutive CD8 expression on thymic selection; implications for the mechanism of CD4 and CD8 lineage commitment.

Semin Immunol. 1994 Aug;6(4):209-12. Review.


Itano, A , D. Cado, F.M. Chan, and E. A. Robey.

A role for the cytoplasmic tail of the b chain of CD8 in thymic selection.

Immunity. 1994; 1:287.


Robey, E.,A. Itano, W. C. Fanslow and  B. J. Fowlkes.

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II MHC mutant mice.

Journal of Experimental Medicine. 1994; 179:1997.


Itano, A , D. Kioussis, and E. A. Robey.

Stochastic component to the development of class I MHC specific T cells.  

Proc.  Natl. Acad.  Sci. 1994; 91: 220.


Robey, E. A., F. Ramsdell, D. Kioussis, W. Sha, D. Loh,  R. Axel, and  B. J. Fowlkes.

The level of CD8 expression can determine the outcome of thymic selection. 

Cell. 1992; 69: 1089.


Robey EA, Ramsdell F, Gordon JW, Mamalaki C, Kioussis D, Youn HJ, Gottlieb PD, Axel R, Fowlkes BJ.

A self-reactive T cell population that is not subject to negative selection.

Int Immunol. 1992 Sep;4(9):969-74.


Robey EA, Fowlkes BJ, Gordon JW, Kioussis D, von Boehmer H, Ramsdell F, Axel R.

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

Cell. 1991 Jan 11;64(1):99-107.


Robey EA, Fowlkes BJ, Pardoll DM.

Molecular mechanisms for lineage commitment in T cell development.

Semin Immunol. 1990 Jan;2(1):25-34. Review.


Before 1990


Robey EA, Wente SR, Markby DW, Flint A, Yang YR, Schachman HK.

Effect of amino acid substitutions on the catalytic and regulatory properties of aspartate  transcarbamoylase.

Proc Natl Acad Sci U S A. 1986 Aug;83(16):5934-8


Robey EA, Schachman HK.

Regeneration of active enzyme by formation of hybrids from inactive derivatives: implications for active sites shared between 

polypeptide chains of aspartate transcarbamoylase.

Proc Natl Acad Sci U S A. 1985 Jan;82(2):361-5.


Robey EA, Schachman HK.

Site-specific mutagenesis of aspartate transcarbamoylase. Replacement of tyrosine 165 in the catalytic chain by serine reduces

enzymatic activity.

J Biol Chem. 1984 Sep 25;259(18):11180-3.


Dunn-Coleman NS, Robey EA, Tomsett AB, Garrett RH.

Glutamate synthase levels in Neurospora crassa mutants altered with respect to nitrogen metabolism.

Mol Cell Biol. 1981 Feb;1(2):158-64.