Selected Publications

Zhao, Z., Zhang, G., Sun, Y. & Winoto, A. (2020) Necroptotic-susceptible dendritic cells exhibit enhanced antitumor activities in mice. Immun Inflamm Dis 8, 468-479. doi: 10.1002/iid3.330

Banta, K. L., Wang, X., Das, P. & Winoto, A. (2018). B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors. J. Biol. Chem. 293, 4724-4734. doi: 10.1074/jbc.RA117.001101

Schock, S. N., Chandra, N. V., Sun, Y., Irie, T., Kitagawa, Y., Gotoh, B., Coscoy, L. & Winoto, A. (2017) Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway. Cell Death Differ. 24, 615-625. doi: 10.1038/cdd.2016.153

Kong, N.R., Davis, M. Chai, L, Winoto, A., Tjian, R. (2016) MEF2C and EBF1 Co-regulate B Cell-Specific Transcription. PLoS Genetics 12: e1005845.

Halkias, J., Yen, B., Taylor, K.T., Reinhartz, O., Winoto, A., Robey, E.A., Melichar, H. J. (2015) Conserved and Divergent Aspects of Human T Cell Development and Migration in Humanized Mice. Immunology and Cell Biology, 93: 716-726.

Schock*, S.N., Young*, J. A., He, T. H., SUn, Y., Winoto, A. (2015) Deletion of FADD in Macrophages and Granulocytes Results in RIP3- and MyD88-dependent Systemic Inflammation. PLoS One 10: e0124391. *co-authorship.

Burger, M. L., Leung, K. K., Bennett, M. J., Winoto, A. (2014) T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity. eLIFE, 3: e03468

Burger*, M. L., Xue*, L., Sun, Y., Kang, C., Winoto, A. (2014) Premalignant PTEN-deficient thymocytes activate miR-146a and miR-146b as a cellular defense against malignant transformation. Blood 123(26):4089-100. *co-authorship.

Young, J. A., He, T. H., Reizis, B. & Winoto, A. Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep 3, 1932-1944 (2013).

Halkias, J. et al. Opposing chemokine gradients control human thymocyte migration in situ. J. Clin. Invest. 123, 2131-2142 (2013).

Melichar*, H., Li*, O., Ross, J., Haber, H., Cado, D., Nolla, H., Robey, E.A. and Winoto, A. (2011) Comparative study of hematopoietic differentiation between human embryonic stem cell lines. PLoS ONE, 6, e19854. *co-authorship.

Young*, J.A., Sermwittayawong*, D., Kim, H., Nandu, S., An, N.S., Erdjument-Bromage, H., Tempst, P., Coscoy, L. and Winoto, A. (2011) Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production. J. Biol. Chem. 286, 6521-6531 (Epub Dec 23, 2010). *co-authorship.

Osborn, S. L., Diehl, G., Han, S-J., Xue, L., Kurd, N., Hsieh, K., Cado, D., Robey, E. A. and Winoto, A. (2010) FADD is a negative regulator of T cell receptor-mediated necroptosis. Proc. Natl. Acad. Sci. USA. 107, 13034-13039 (Direct submission). 

Xue, L., Chiang, L., He, B., Zhao, YY and Winoto, A. (2010) FoxM1, a forkhead transcription factor is a master cell cycle regulator for mouse mature T cells but not double positive thymocytes. PLoS ONE 5, e929.

Xue, L. et al. (2010) Coupling of the cell cycle and apoptotic machineries in developing T cells. J. Biol. Chem. 285, 7556-7565.

Thompson, J., Burger, M., Whang, H. and Winoto, A. (2010) Protein Kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis. Eur. J. Immunol.40: 2041-2049 (published online April 21, 2010).

Haynes et al. (2010) CD11c+ Dendritic Cells and B cells Contribute to the Tumoricidal Activity of Anti-DR5 Antibody Therapy in Established Tumors. J. Immunol. 185, 532-541.

Xue, L., Nolla, H., Suzuki, A., Mak, T.W. and Winoto, A (2008) Normal Development is an Integral Part of Tumorigenesis in T-cell specific PTEN-deficient Mice. Proc. Natl. Acad. Sci. USA. 105, 2022-2027.

Thompson, J. and Winoto, A. (2008) Bcl-2 associates with the Nur77 family members and exposes its BH3 pro-apoptotic domain during Negative Selection. J. Exp. Med. 205, 1029-1036.

Sohn, S. J., Lewis, G. and Winoto, A. (2008) Non-redundant Function of the MEK5-ERK5 Pathway in Thymocyte Apoptosis. EMBO J. 27, 1896-1906.

Xue, L., Chiang, L., Kang, C. and Winoto, A. (2008) The role of the PI3K-AKT kinase pathway in T cell development beyond the beta checkpoint. Eur. J. Immunol. 8, 3200-3207.

Osborn, S., Sohn, S.J. and Winoto A. (2007) Constitutive phosphorylation mutation in fadd results in early cell cycle defects.Journal of Biological Chemistry, 282:22786-22792. Cover PhotoDownload

Yue, H.H., Diehl, G.E. and Winoto, A. (2005) Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death and Differentiation, 12, 94-97.

Alappat, et al. (2005). Phosphorylation of FADD at Serine 194 by CKI-alpha regulates Its Nonapoptotic Activities. Mol. Cell, 19, 321-332.supplementary

Sohn, S.J., Li, D., Lee, L. K. and Winoto, A. (2005) Transcriptional Regulation of Tissue-specific genes by the ERK5 MAP Kinase. Mol. Cell Biol., 25, 8553-8566. figure 1, Figure 2 Cover Photo

Xing, Z., Conway, E.M., Kang, C. and Winoto, A. (2004) Essential role of survivin, an inhibitor of apoptosis (IAP) in T cell development, maturation and homeostasis. J. Exp. Med. 199, 69-80.

Huang, Y., Li, D., Winoto, A., and Robey, E. (2004) Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch and positive selection signals. Proc. Natl. Acad. Sci. USA, 101, 4936-4941. supplementary1 supplementary 2

Diehl et al. (2004) TRAIL-R as a negative regulator of innate immune cell responses. Immunity, 21, 877-889.