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Key research papers

Meyer H-J, Rape M. (2014) Enhanced protein degradation by branched ubiquitin chains. Cell, in press

Song L, Craney A, Rape M. (2014) Microtubule-dependent regulation of mitotic protein degradation. Mol Cell. 2014 Jan 23;53(2):179-92.

Jin L, Pahuja KB, Wickliffe KE, Gorur A, Baumgaertel C, Schekman R, Rape M.
 (2012)
Ubiquitin-dependent regulation of COPII coat size and function.
Nature. 2012 Feb 22;482(7386):495-500.

Williamson A, Banerjee S, Zhu X, Philipp I, Iavarone AT, Rape M. (2011) Regulation of ubiquitin chain initiation to control the timing of substrate degradation. Mol Cell. 2011 Jun 24;42(6):744-57.

Wickliffe, K.E.*, Lorenz, S.*, Wemmer, D.E., Kuriyan, J., and Rape, M. (2011) Mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell, 144, 769-81.

Matsumoto, M.L.*, Wickliffe, K.E.*, Dong, K.C., Yu, C., Bosanac, I., Bustos, D., Phu, L., Kirkpatrick, D.S., Hymowitz, S.G., Rape, M., Kelley, R.F., and Dixit, V.M. (2010) K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. Mol. Cell 39, 477-84.

Song, L., and Rape, M. (2010) Regulated degradation of spindle assembly factors by the anaphase-promoting complex. Mol. Cell 38, 369.82.

Jin, L.*, Williamson, A.*, Banerjee, S., Phillip, I., and Rape M. (2008). Mechanism of ubiquitin chain formation by the human Anaphase-Promoting Complex. Cell 133, 653-665.

Stegmeier, F.*, Rape, M.*, et al. (2007). Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 446, 876-881.

Reddy, S.K.*, Rape, M.*, and Kirschner M.W. (2007). Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446, 921-925.


Key reviews

Komander D, Rape M. (2012) The ubiquitin code. Annu Rev Biochem, 2012 Apr 10; 81:203-29

Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M. (2011) K11-linked ubiquitin chains as novel regulators of cell division. Trends Cell Biol. 2011 Nov;21(11):656-63.

Ye, Y., and Rape, M. (2009) Building ubiquitin chains: E2 enzymes at work. Nat. Rev. Mol. Cell Biol. 10, 755-64.

Complete publication list

Meyer H-J, Rape M. (2014) Enhanced protein degradation by branched ubiquitin chains. Cell 2014, in press

Locke MN, Rape M. (2014) DNA Damage: Walking the edge. Nat Chem Biol. 2014 Mar 18;10(4):243-4.

Song L, Craney A, Rape M. (2014) Microtubule-dependent regulation of mitotic protein degradation. Mol Cell. 2014 Jan 23;53(2):179-92.

Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H. (2014) The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente. EMBO Rep. 2014 Jan;15(1):7-11.

Craney A, Rape M. (2013) Dynamic regulation of ubiquitin-dependent cell cycle control. Curr Opin Cell Biol. 2013 Dec;25(6):704-10

Meyer HJ, Rape M. (2013)
Caught in the act. Elife. 2013 Aug 8;2:e01127.

Lorenz S, Cantor AJ, Rape M, Kuriyan J. (2013) Macromolecular juggling by ubiquitylation enzymes. BMC Biol. 2013 Jun 25;11:65.

McGourty CA, Rape M. (2013) Cullin' PLK1 from kinetochores. Nat Cell Biol. 2013 Apr;15(4):347-8.

Williamson A, Werner A, Rape M. (2013) The Colossus of ubiquitylation: decrypting a cellular code. Mol Cell. 2013 Feb 21;49(4):591-600.

Komander D, Rape M. (2012) The ubiquitin code. Annu Rev Biochem, 2012 Apr 10; 81:203-29

Jin L, Pahuja KB, Wickliffe KE, Gorur A, Baumgaertel C, Schekman R, Rape M.
 (2012)
Ubiquitin-dependent regulation of COPII coat size and function.
Nature. 2012 Feb 22;482(7386):495-500.

Mocciaro A, Rape M. (2012)
Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control. J Cell Sci. 2012 Jan 15;125(Pt 2):255-63.

Newton K, Matsumoto ML, Ferrando RE, Wickliffe KE, Rape M, Kelley RF, Dixit VM.  (2012)
Using linkage-specific monoclonal antibodies to analyze cellular ubiquitylation. Methods Mol Biol. 2012;832:185-96.

Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M. (2011)
K11-linked ubiquitin chains as novel regulators of cell division. Trends Cell Biol. 2011 Nov;21(11):656-63.

Williamson A, Banerjee S, Zhu X, Philipp I, Iavarone AT, Rape M. (2011)
Regulation of ubiquitin chain initiation to control the timing of substrate degradation. Mol Cell. 2011 Jun 24;42(6):744-57.

Meyer, H.J., and Rape, M. (2011) Processive ubiquitin chain formation by the
anaphase-promoting complex. Semin. Cell Dev. Biol. 22(6):544-5

Wickliffe, K.E.*, Lorenz, S.*, Wemmer, D.E., Kuriyan, J., and Rape, M. (2011) Mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell, 144, 769-81.


Song, L., and Rape, M. (2011) Substrate-specific regulation of ubiquitination by the anaphase-promoting complex. Cell Cycle 10, 52-56.

Matsumoto, M.L.*, Wickliffe, K.E.*, Dong, K.C., Yu, C., Bosanac, I., Bustos, D., Phu, L., Kirkpatrick, D.S., Hymowitz, S.G., Rape, M., Kelley, R.F., and Dixit, V.M. (2010) K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. Mol. Cell 39, 477-84.

Song, E.J.*, Werner, S.L.*, Neubauer, J., Stegmeier, F., Aspden, J., Rio, D., Harper, J.W., Elledge, S.J., Kirschner, M.W., and Rape, M. (2010) The Prp19 complex and the Usp4/Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev. 24, 1434-47.

Song, L., and Rape, M. (2010) Regulated degradation of spindle assembly factors by the anaphase-promoting complex. Mol. Cell 38, 369.82.

Ye, Y., and Rape, M. (2009) Building ubiquitin chains: E2 enzymes at work. Nat. Rev. Mol. Cell Biol. 10, 755-64.

Williamson, A.*, Wickliffe, K.E.*, Mellone, B.G., Song, L., Karpen, G.H., and Rape, M. (2009) Identification of a physiological E2 module for the human anaphase-promoting complex. Proc. Natl. Acad. Sci. U S A. 106, 18213-8.

Williamson, A., Jin, L., and Rape, M. (2009) Preparation of synchronized human cell extracts to study ubiquitination and degradation. Methods Mol. Biol. 545, 301-12.

Wickliffe, K., Williamson, A., Jin, L., and Rape, M. (2009) The multiple layers of ubiquitin-dependent cell cycle control. Chem. Rev. 109, 1537-48.

Jin, L.*, Williamson, A.*, Banerjee, S., Phillip, I., and Rape M. (2008). Mechanism of ubiquitin chain formation by the human Anaphase-Promoting Complex. Cell 133, 653-665.

Song, L., and Rape, M. Reverse the curse--the role of deubiquitination in cell cycle control. Curr. Opin. Cell Biol. 20, 156-63.

Stegmeier, F.*, Rape, M.*, et al. (2007). Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 446, 876-881.

Reddy, S.K.*, Rape, M.*, and Kirschner M.W. (2007). Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446, 921-925.

Rape, M., Reddy, S.K. and Kirschner, M.W. (2006). The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell 124, 89-103.

Richly, H.*, Rape, M.*, Braun, S., Rumpf, S., Hoege, C., and Jentsch S. (2005). A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell 120, 73-84.

Rape, M. and Kirschner, M.W. (2004). Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432, 588-595.

Rape, M., Hoppe, T., Gorr, I. , Kalocay, M., Richly, H., and Jentsch S. (2001). Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48. Cell 107, 667-677

* These authors contributed equally to this work.