Rape Lab

Key Research Articles

A complete list of publications can be found on Pubmed.
  1. Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation Craney A*, Kelly A*, Jia L, Fedrigo I, Yu H, Rape M PNAS. 2016 113: 5140-5145. [pubmed] [pdf]
  2. Cell-fate determination by ubiquitin-dependent regulation of translation Werner A, Iwasaki S, McGourty C, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia N, Rape M Nature. 2015 525: 523-527. [pubmed] [pdf]
  3. Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate Kelly A*, Wickliffe KE*, Song L*, Fedrigo I, Rape M Mol Cell. 2014 56: 232-245. [pubmed] [pdf]
  4. Enhanced protein degradation by branched ubiquitin chains Meyer HJ, Rape M Cell. 2014 157: 910-921. [pubmed] [pdf]
  5. Microtubule-dependent regulation of mitotic protein degradation Song L, Craney A, Rape M Mol Cell. 2014 53: 179-192. [pubmed] [pdf]
  6. Ubiquitin-dependent regulation of COPII coat size and function Jin L*, Pahuja KB*, Wickliffe KE, Gorur A, Baumgaertel C, Schekman R, Rape M Nature. 2012 482: 495-500. [pubmed] [pdf]
  7. Regulation of ubiquitin chain initiation to control the timing of substrate degradation Williamson A*, Banerjee S*, Zhu X, Philipp I, Iavarone AT, Rape M Mol Cell. 2011 42: 744-757. [pubmed] [pdf]
  8. The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2 Wickliffe KE*, Lorenz S*, Wemmer DE, Kuriyan J, Rape M Cell. 2011 42: 744-757. [pubmed] [pdf]
  9. K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody Matsumoto ML*, Wickliffe KE*, Dong KC, Yu C, Bosanac I, Bustos D, Phu L, Kirkpatrick DS, Hymowitz SG, Rape M, Kelley RF, Dixit VM Mol Cell. 2010 39: 477-84. [pubmed] [pdf]
  10. Regulated degradation of spindle assembly factors by the anaphase-promoting complex Song L, Rape M Mol Cell. 2010 38: 369-382. [pubmed] [pdf]
  11. Identification of a physiological E2 module for the human anaphase-promoting complex Williamson A, Wickliffe KE, Mellone BG, Song L, Karpen GH, Rape M. PNAS. 2009 106: 18213-18218. [pubmed] [pdf]
  12. Mechanism of ubiquitin chain formation by the human anaphase-promoting complex Jin L*, Williamson A*, Banerjee S, Phillip I, Rape M Cell. 2008 133: 653-665. [pubmed] [pdf]
  13. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Stegmeier F*, Rape M*, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ Nature. 2007 446: 876-881. [pubmed] [pdf]
  14. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation Reddy SK*, Rape M*, Margansky WA, Kirschner MW Nature. 2007 446: 921-925. [pubmed] [pdf]

Key Reviews

  1. The Colossus of ubiquitylation: decrypting a cellular code Williamson A*, Werner A*, Rape M Mol Cell. 2013 49: 591-600. [pubmed] [pdf]
  2. Dynamic regulation of ubiquitin-dependent cell cycle control Craney A, Rape M. Curr Opin Cell Biol. 2013 25: 704-710. [pubmed] [pdf]
  3. The Ubiquitin Code Komander D, Rape M Annu Rev Biochem. 2012 81: 203-29. [pubmed] [pdf]
  4. Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control Mocciaro A, Rape M J Cell Sci. 2012 125: 255-263. [pubmed] [pdf]
  5. K11-linked ubiquitin chains as novel regulators of cell division Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M Trends Cell Biol. 2011 21: 656-663. [pubmed] [pdf]
  6. Building ubiquitin chains: E2 enzymes at work Ye Y, Rape M Nat Rev Mol Cell Biol. 2009 10: 755-764. [pubmed] [pdf]
* These authors contributed equally.