Terry Machen
Lab Personnel

Selected papers of ours from various scientific journals are listed below. You may either read the corresponding abstract or download the article in PDF format (designated by the Acrobat symbol).

Illek B, Fu Z, Schwarzer C, Banzon T, Jalickee S, Miller SS, Machen TE (2008). Flagellin-stimulated Cl- secretion and innate immune responses in airway epithelia: role for p38. . Am J Physiol Lung Cell Mol Physiol.295(4):L531-42.

Kevin Hybiske, Zhu Fu, Christian Schwarzer, Jill Tseng, Jiun Do, Natalie Huang, and Terry E. Machen. (2007). Effects of cystic fibrosis transmembrane conductance regulator and DeltaF508CFTR on inflammatory response, ER stress, and Ca2+ of airway epithelia. . Am J Physiol Lung Cell Mol Physiol.293(5):L1250-60.

Christian Schwarzer, Beate Illek, Jung Suh, James Remington, Horst Fischer, and Terry Machen (2007). Organelle redox of CF and CFTR-corrected airway epithelia . Free Radical Biol Med. 43(2):300-16

Terrry Machen (2006). Innate Immune Response in CF Airway Epithelia:  Hyperinflammatory? Amer. J. Physiol. Cell Physiol. 291, C218-C230.

Zhu Fu, K Bettega, S Carroll, KR Buchholz, Terry Machen (2006). Role of Ca in responses of airway epithelia to P. aeruginosa, flagellin, ATP and thapsigargin. Amer. J. Physiol.,Lung Cell Mol Physiol. 292, L353-64.

Jill Tseng, Jiun Do, Jonathan Widdicombe, Terry Machen (2006). Innate immune response of human airway epithelium to P. aeruginosa flagellin and TNFa and IL1b. Am. J. Physiol. Cell Physiol. 290, C678-90.

Kevin Hybiske, Jeffrey Ichikawa, Vera Huang, Stephen Lory and Terry Machen (2004). Cystic fibrosis airway epithelial cell polarity and bacterial flagellin determine host response to P. aeruginosa. Cell Microbiol. 6, 49-62.

Terry Machen, Mary Jae Leigh, Carmen Taylor, Tohru Kimura, Shinji Asano and Hsiao-Ping Moore (2003). pH of TGN and recycling endosomes of H/K-ATPase-transfected HEK 293 cells: implications for pH regulation in the secretory pathway. Am. J. Physiol. 285, C205-C214.

Tobias Jacob, Rebecca. Lee, Joanne Engel and Terry Machen (2002). Modulation of cytosolic Ca2+ concentration in airway epithelial cells by Pseudomonas aeruginosaInfection and Immunity. 70, 6399-6408.

Minnie Wu, Michael Grabe, Stephen Adams, Roger Tsien, Hsiao-Ping.Moore and Terry Machen (2001). Mechanisms of pH regulation in the regulated secretory pathway. J. Biol. Chem. 276, 33027-33035.

Terry Machen, Grischa Chandy, Minnie Wu, Michael Grabe, and Hsiao-Ping Moore. (2001). CFTR and H+ permeability in regulation of Golgi pH.  Proceedings of the International Symposium on HC03- and Cystic Fibrosis, P.Quinton, ed. J. Pancreas. 2(4), 229-236.

Grischa Chandy,  Michael.Grabe, Hsiao-Ping Moore and Terry Machen (2001). Proton leak and CFTR in regulation of Golgi pH in airway epithelial cells. Amer. J. Physiol. 281, C908-C921.

Sasha Blaug, Kevin Hybiske, Jonathan Cohn, Gary Firestone, Terry Machen and Sheldon.Miller (2001). ENaC and CFTR dependent ion and fluid transport in mammary epithelia. Amer. J. Physiol. 281, C633-648.

Minnie Wu, Juan Llopis, Stephen Adams, J.Michael McCaffery, Ken Teter, Markku. Kulomaa, Terry Machen, Hsiao-Ping.Moore and Roger Tsien (2000). Studying organelle physiology using targeted avidin and fluorescein-avidin. Methods in Enzymology. 327, 546-564.

Minnie Wu, Juan Llopis, Stephen Adams, J. Michael McCaffery, Terry Machen, Hsiao-Ping Moore and Roger Tsien (2000). Use of organelle-targeted avidin and membrane-permeant, fluorescent biotin to measure pH regulation in the ER and trans-Golgi. Chemistry and Biology. 7, 197-209.

Alfred Lee, Dar Chow, Brian Haus, Wanru Tseng, David Evans, Suzanne Fleiszig, Grischa Chandy, and Terry Machen (1999). Airway epithelial tight junctions and binding and cytotoxicity of Pseudomonas aeruginosa. Am J Physiology. 277, L204-L217.

Ken Teter, Grischa Chandy, Beatriz Qui?ones, Kristina Pereyra, Terry Machen, and Hsiao-Ping Moore (1998). Cellubrevin-targeted fluorescence uncovers heterogeneity in the recycling endosomes. J Biol Chem. 273, 19625-19633.

Beate Illek, Horst Fischer, and Terry Machen (1998). Genetic disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO-3. Am J Physiology. 275, G1221-G1226.

Horst Fischer, Beate Illek, and Terry Machen (1998). Regulation of CFTR by protein phosphatase 2B and protein kinase C. Pflugers Archiv. 436, 175-181.

Paul Sammak, Lee Hinman, Phuong Tran, Michael Sjaastad, and Terry Machen (1997). How do injured cells communicate with the surviving cell monolayer? J Cell Science. 110, 465-475.

AM Hofer, WR Schlue, S Curci, and TE Machen (1995). Spatial distribution and quantitation of free luminal [Ca] within the IP3-sensitive internal store of individual BHK-21 cells: ion dependence of IP3-induced Ca release and reloading. FASEB Journal. 9, 788-798.

Horst Fischer and Terry Machen (1994). CFTR displays voltage dependence and two gating modes during stimulation. J Gen Physiology. 104, 541-566.

JH Poulsen, Horst Fischer, Beate Illek, and Terry Machen (1994). Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci. 91, 5340-5344.

ME Huflejt, RA Blum, SG Miller, HP Moore, and TE Machen (1994). Regulated Cl transport, K and Cl permeability, and exocytosis in T84 cells. J Clin Invest. 93, 1900-1910.

AM Hofer and TE Machen (1993). Technique for in situ measurement of calcium in intracellular inositol 1,4,5-trisphosphate-sensitive stores using the fluorescent indicator mag-fura-2. Proc Natl Acad Sci. 90, 2598-2602.

MD Sjaastad, KS Zettl, G Parry, GL Firestone, and TE Machen (1993). Hormonal regulation of the polarized function and distribution of Na/H exchange and Na/HCO3 cotransport in cultured mammary epithelial cells. J Cell Biology. 122, 589-600.