Selected Publications

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. [Li Z, Guo J, Wu Y, Zhou Q. (2012) Nucleic Acids Res.]

The ubiquitin ligase Siah1 controls ELL2 stability and formation of Super Elongation Complexes (SECs) to modulate gene transcription. [M. Liu, J. Hsu, C. Chan, Z. Li, and Q. Zhou (2012) Mol Cell, 46, 325-334]

RNA Polymerase II elongation control. [Q. Zhou, T. Li, and D.H. Price (2012) Annu. Rev. Biochem. 81, 119-143]

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. [N. He, C.K. Chan, B. Sobhian, Y. Xue, M. Liu, M. Benkirane, and Q. Zhou (2011) Proc. Natl. Acad. Sci. USA.108, 14719-14720]

The control of HIV transcription: Keeping RNA Polymerase II on track. [M. Ott, M. Geyer, and Q. Zhou (2011) Cell Host & Microbe 10, 426-435]

HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. [N. He, M. Liu, J. Hsu, Y. Xue, S. Chou, A. Burlingame, N.J. Krogan, T. Alber, and Q. Zhou (2010). Mol Cell 38, 428-438]

A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. [N. He, N.S. Jahchan, E. Hong, M. A. Bayfield, R. J. Maraia, K. Luo, and Q. Zhou (2008) Mol. Cell 29, 588-599]

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression. [Z. Yang, N. He and Q. Zhou (2008) Mol. Cell. Bio. 28, 967-976]

PP2B and PP1α cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. [C. Chen, M. Liu, H. Li, Y. Xue, W.N. Ramey, N. He, N. Ai, H. Luo, Y. Zhu, N. Zhou, and Q. Zhou (2008) Genes & Dev.22, 1356-1368]

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription. [M. Barboric, J. H. N. Yik, N. Czudnochowski, Z. Yang, R. Chen, X. Contreras, M. Geyer, B. M. Peterlin, and Q. Zhou (2007) Nuc. Acids Res. 35, 2003-2012]

Recruitment of P-TEFb for stimulation of transcriptional elongation by bromodomain protein Brd4. [Z. Yang, J. H. N. Yik, R. Chen, M. K. Jang, K. Ozato and Q. Zhou (2005) Mol. Cell 19, 535-545]

Inhibition of P-TEFb (CDK9/cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. [J. H. N. Yik, R. Chen, R. Nishimura, J. L. Jennings, A. J. Link and Q. Zhou (2003) Mol. Cell 12, 971-982]

The 7SK small nuclear RNA inhibits the Cdk9/cyclin T1 kinase to control transcription. [Z. Yang, Q. Zhu, K. Luo, and Q. Zhou (2001) Nature 414, 317-322]

Stimulatory effect of splicing factors on transcriptional elongation. [Y. Fong and Q. Zhou (2001) Nature 414, 929-933]