Publications
2024
Methylglyoxal is an antibacterial effector produced by macrophages during infection.
bioRxiv [Preprint]. 2024 Nov 3:2024.11.03.621721. doi: 10.1101/2024.11.03.621721.
(2024)
Temporal and spatial dynamics of Listeria monocytogenes central nervous system infection in mice.
Proc Natl Acad Sci U S A 2024 121 (17) e2320311121 https://doi.org/10.1073/pnas.2320311121
(2024)
Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy.
bioRxiv
doi: https://doi.org/10.1101.2024.02.15.580555
(2024)
Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as a source of essential L-cysteine.
Infect Immun.
2024 Jan 30:e0042223. doi: 10.1128/iai.00422-23. Online ahead of print. PMID: 38289071
(2024)
2023
The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine.
mBio. 11 Sep 2023: e0107423. doi: 10.1128/mbio.01074-23. Online ahead of print. Editor's Pick.
(2023)
Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
PLoS Pathog. 2023 Jun 23;19(6): e1011088. doi: 10.1371/journal.ppat.1011088. Online ahead of print. PMCID: PMC10325092
(2023)
Distinct energy-coupling factor transporter subunits enable flavin acquisition and extracytosolic trafficking for extracellular electron transfer in Listeria monocytogenes.
mBio. 2023 Feb 28;14(1):e0308522. doi: 10.1128/mbio.03085-22. Epub 2023 Feb 6. PMCID: PMC9973259
(2023)
2022
para-Aminobenzoic acid biosynthesis is required for Listera monocytogenes growth and pathogenesis.
Infect Immun. 2022 Nov 17:90(11):e0020722. Doi: 10.1128/iai.00207-22. Epub 2022 Nov 1. PMCID: PMC9670987
(2022)
Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis.
Elife. 2022 Apr 5;11:e75424. Doi: 10.7554/eLife.75424. PMID: 35380108.
(2022)
RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth.
Proc Natl Acad Sci USA. 2022 Mar 29;119(13):e2122173119. doi: 10.1073/pnas.2122173119. Epub 2022 Mar 22. PMID 35316134
(2022)
2021
Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes
PLOS Pathogens: 2021 Aug 18:17(8):e1009819. doi: 10.1371/journal.ppat.1009819. PMCID: PMC8372916
(2021)
2020
Secretion of c-di-AMP by Listeria monocytogenes leads to a STING-dependent antibacterial response during enterocolitis.
Infect Immun. 2020 Oct 5:IAI.00407-20. doi: 10.1128/IAI.00407-20. PMID: 33020211
(2020)
Secondary structure of the mRNA encoding listeriolysin O is essential to establish the replicative niche of L. monocytogenes.
Proc Natl Acad Sci - USA. www.pnas.org/cgi/doi/10.1073/pnas.2004129117
(2020)
(p)ppGpp and ci-di-AMP homeostasis is controlled by CbpB in Listeria monocytogenes.
mBio. 2020 Aug 25;11(4):e01625-20. doi: 10.1128/mBio.01625-20. PMID: 32843560
(2020)
TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes.
PLoS Pathog. 2020 Jul 7;16(7):e1008622. doi: 10.1371/journal.ppat.1008622. eCollection 2020 Jul. PMCID: PMC7340287
(2020)
The nonmevalonate pathway of isoprenoid biosynthesis supports anaerobic growth of Listeria monocytogenes.
Infect Immun. 2020 Jan 22;88(2). doi: 10.1128/IAI.00788-19. PMCID: PMC6977116
(2020)
Why is Listeria monocytogenes such a potent inducer of CD8+ T-cells?
Cell Microbiol. 2020 April 22(4):e13175. Doi: 10.1111/cmi.13175. Review. PMCID: PMC100999
(2020)
An Inducible Cre-lox System to Analyze the Role of LLO in Listeria monocytogenes Pathogenesis
Toxins. 2020 Jan 7 12(1) doi: 10.3390/toxins12010038. PMCID: PMC7020504
(2020)
2019
A multiorgan trafficking circuit provides purifying selection of Listeria monocytogenes virulence genes.
mBio. 2019 Dec 17;10(6). pii: e02948-19. doi: 10.1128/mBio.02948-19. PMID: 31848289
(2019)
Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria.
Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 201915678. doi: 10.1073/pnas.1915678116. [Epub ahead of print] PMID: 31818955
(2019)
A potent and effective suicidal Listeria vaccine platform.
Infect Immun. 2019 Jul 23;87(8) pii: e00144-19. doi: 10.1128/IAI.00144-19. Print 2019 Aug. PMCID: PMC6652770
(2019)
2018
Listeriolysin O: a phagosome-specific cytolysin revisited.
Cell Microbiol. Dec 4:312988. Doi: 10.1111/cmi.12988. [Epub ahead of print]. Review. NIHMS1515399
(2018)
A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria.
Nature. 2018 Sep 12. doi: 10.1038/s41586-018-0498-z. [Epub ahead of print] PMCID: PMC6221200
(2018)
Recombinant Listeria promotes tumor rejecton by CD8+ T cell-dependent remodeling of the tumor microenvionment.
Proc Natl Acad Sci USA. July 23, 2018. 201801910. doi: 10.1073/pnas.1801910115. [Epub ahead of print] PMCID: PMC6094133
(2018)
The listeriolysin O PEST-like sequence prevents plasma membrane damage during Listeria infection by promoting AP-2-mediated endocytosis.
Cell Host Microbe. 13 June 2018. 23:786-795.e5. doi: 10.1016/j.chom.2018.05.006. PMCID: PMC6007032
(2018)
Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol.
Cellular Microbiol. 2018 May 3:e12854. doi: 10.1111/cmi.12854. [Epub ahead of print] PMID: 29726107
(2018)
STING-activating adjuvants elicit a Th17 immune response and protect against Mycobacterium tuberculosis infection.
Cell Rep. 2018 May 1;23(5):1435-1447. doi: 10.1016/j.celrep.2018.04.003. PMID: 29719256
(2018)
Listeria monocytogenes triggers non-canonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy.
Proc Natl Acad Sci U S A
115(2):
E210-E217. doi: 10.1073/pnas.1716055115. Epub 2017 Dec 26
(2018)
2017
Activation of the Listeria monocytogenes virulence program by a reducing environment.
mBio.
8(5):
doi: 10.1128/mBio.01595-17 17 October 2017 mBio e01595-17. PMCID: PMC5646252
(2017)
Identification of Coxiella burnetti CD8+ epitopes and delivery by attenuated Listeria monocytogenes as a vaccine vector in a C57BL/6 mouse model.
J Infect Dis. 2017 May 15;215(10):1580-1589. doi: 10.1093/infdis/jiw470. NIHMSID: 841238
(2017)
c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance, and osmoregulation.
Mol Microbiol. 2017 Apr;104(2):212-233. doi: 10.1111/mmi.13622. Epub 2017 Mar 8. PMCID: PMC5391996
(2017)
Activity of the pore-forming virulence factor Listeriolysin O is reversibly inhibited by naturally occuring S-glutathionylation.
Infect Immun. 2017 Mar 23;85(4). pii: e00959-16. doi: 10.1128/IAI.00959-16. Print 2017 Apr. PMCID: PMC5364301
(2017)
Listening to each other: infectious disease and cancer immunology.
Sci. Immunol. 2, eaai9339 13 Jan 2017. doi: 10.1126/sciimmunol.aai9339.
(2017)
2016
An in vivo selection to identify how Listeria monocytogenes recognizes the intracellular environment.
PLoS Pathog. 2016 Jul 14;12(7):e1005741. doi: 10.1371/journal.ppat.1005741. eCollection 2016 Jul. PMCID: PMC4945081
(2016)
SpoVG is a conserved RNA-binding protein that regulates Listeria monocytogenes lysozyme resistance, virulence, and swarming motility.
MBio. 2016 Apr 5;7(2). Pii: e00240-16. doi: 10.1128/mBio.00240-16. PMCID: PMC4959528
(2016)
2015
Ribosome hibernation facilitates tolerance of stationary-phase bacteria to aminoglycosides.
Antimicrob Agents Chemother. 2015 Nov;59(11):6992-9. doi: 10.1128/AAC.01532-15. Epub 2015 Aug 31. PMCID: PMC4604360
(2015)
Strategies used by bacteria to grow in macrophages.
Book chapter in: Myeloid Cells in Health and Disease: A Synthesis. ASM Press. PMCID: PMC4922531
(2015)
The PAMP c-di-AMP is essential for Listeria monocytogenes growth in rich but not minimal media, due to a toxic increase in (p)ppGpp.
Cell Host Microbe. 2015 Jun 10;17(6):788-98. doi: 10.1016/j.chom.2015.05.006. Epub 2015 May 28. PMCID: PMC4469362
(2015)
RNA-based fluorescent biosensors for live cell imaging of second messenger cyclic di-AMP.
J Am Chem Soc. 2015 May 27;137(20):6432-5. Doi: 10.1021/jacs.5b00275. EPub 2015 May 15. PMCID: PMC4521591
(2015)
Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages.
Infect Immun. 2015 May;83(5):2175-84. PMID 25776746. PMCID: PMC4399067
(2015)
STING agonist formulated cancer vaccines can cure established tumor resistant to PD-1 blockade.
Sci Transl Med. 2015 Apr 15;7(283):283ra52. doi: 10.1126/scitranslmed.aaa4306. PMCID: PMC4504692
(2015)
Host actin polymerization tunes the cell division cycle of an intracellular pathogen.
Cell Rep. 2015 Apr 15. pii: S2211-1247(15)00325-3. doi: 10.1016/j.celrep.2015.03.046. [Epub ahead of print] PMCID: PMC4417095
(2015)
A prl mutation in secY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutants.
J. Bacteriol. 2015 Mar;197(5):932-42. doi: 10.1128/JB.02284-14. Epub 2014 Dec 22. PMCID: PMC4325107
(2015)
The Listeria monocytogenes hibernation-promoting factor (HPF) is required for the formation of 100S ribosomes, optimal fitness, and pathogenesis.
J Bacteriol. 2015 Feb 1;197(3):581-91. doi: 10.1128/JB.02223-14. Epub 2014 Nov 24. PMCID: PMC4285973
(2015)
Glutathione activates virulence gene expression of an intracellular pathogen. Article.
Nature. 2015 Jan 8:517(7533):170-3. doi: 10.1038/ nature14029. PMCID: PMC4305340
(2015)
2014
Listeria monocytogenes is resistant to lysozyme through the regulation, not acquisition, of cell wall modifying enzymes.
J. Bacteriol. 2014 Nov;196(21):3756-67. doi: 10.1128/JB.02053-14. Epub 2014 Aug 25. PMCID: PMC4248804
(2014)
Comparison of widely used Listeria monoctyogenes strains EGD, 10403S, and EGD-e highlights genomic differences underlying variations in pathogenicity.
mBio. 2014 Mar 25;5(2):e00969-14.5(2): doi:10.1128/mBio.00969-14. PMCID: PMC3977354
(2014)
STING-dependent Type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes.
PLoS Pathog. 2014 Jan;10(1):e1003861. doi: 10.1371/journal.ppat.1003861. Epub 2014 Jan 2. PMCID: PMC3879373
(2014)
2013
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection.
. mBio. 2013 May 28;4(3). Doi:pii:e00282-13. 1128/mBio.00282-13. PMCID: PMC3663569
(2013)
2012
Development of single-gene, signature-tag-based approach in combination with alanine mutagenesis to identify listeriolysin O residues critical for the in vivo survival of Listeria monocytogenes.
Infect Immun. 2012 Jun;80(6):2221-30. PMCID: PMC3370594
(2012)
Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.
Cell Host & Microbe. May 17, 2012: 11:469-480. PMCID: PMC3662372
(2012)
Yogi Berra, Forrest Gump, and the discovery of Listeria actin comet tails. Review.
Mol Biol Cell. 2012 Apr;23(7):1141-5. Review. PMCID: PMC3376002
(2012)
Hyper-induction of host interferon β by a Listeria monocytogenes strain naturally over-expressing the multi-drug efflux pump MdrT.
Infect Immun. 2012 Apr;80(4):1537-45. Epub 2012 Jan 30. PMCID: PMC3318417
(2012)
Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity.
Review. Adv. Immunol. 2012;113:135-56. PMID: 22244582
(2012)
Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs.
Infect Immun. 2012 Feb;80(20):730-32. Epub 2011 Nov 14. PMCID: PMC3264322
(2012)
2011
Post-translocation chaperone PrsA2 regulates the maturation and secretion of Listeria monocytogenes proprotein virulence factors.
J. of Bacteriol. Nov;193(21):5961-70. Epub 2011 Sep 9. PMCID: PMC3194926
(2011)
Mutations of the Listeria monocytogenes peptidoglycan N-deacetylase and O-acetylase result in enhanced lysozyme sensitivity, bacteriolysis and hyper-induction of innate immune pathways.
Infect Immun. 2011 Sept;79(9);3596-606 Epub 2011 Jul 18. PMCID: PMC3165460
(2011)
Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.
Proc Natl Acad Sci USA. Jul 26;108(30):12419-24. Epub 2011 Jul 11. PMCID: PMC3145703
(2011)
Dynamic imaging of the effector immune response to Listeria infection in vivo.
PLoS Pathog. 2011 Mar;7(3):e1001326. Epub 2011 Mar 24 2011. PMCID: PMC3063765
(2011)
The N-ethyl-N-nitrosourea-induced Goldenticket (Gt) mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.
Infect Immun. 2011 Feb;79(2):688-94. Epub 2010 Nov 22. PMCID: PMC3028833
(2011)
2010
c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.
Science. 2010 Jun 25;328(5986): 1703-5. Epub 2010 May 27. PMCID: PMC3156580
(2010)
Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.
Cell Host Microbe. 2010 May 20;7(5):412-9. Epub 2010 Apr 22. PMCID: PMC2947455
(2010)
Listeriolysin O is necessary and sufficient to induce autophagy during Listeria monocytogenes infection.
PLoS One. 2010 Jan 6:5(1). PMCID: PMC2797616
(2010)
2009
Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria.
PLoS Pathog. 2009 Sep;5(9):e1000568. Epub 2009 Sep 4. PMCID: PMC2731223
(2009)
Listeria monocytogenes 6-phosphogluconolactonase (pgl) mutants induce increased activation of a host cytosolic surveillance pathway.
Infect Immun., 2009 Jul;77(7):3014-22. PMCID: PMC2708561
(2009)
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.
Review. Cell Host Microbe. 2009 Jul 23;6(1):10-21. PMCID: PMC 2777727
(2009)
Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-proline isomerase, PrsA2, that contribute to its hemolytic phenotype.
J Bacteriol. 2009 Jun;191(12):3950-64. EPub 2009 Apr 17. PMCID: PMC2698408
(2009)
Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax.
Infect Immun. 2009 Apr;77(4):1649-63. Epub 2009 Jan 21. PMCID: PMC2663168
(2009)
2008
Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity.
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10191-6. Epub 2008 Jul 16. PMCID: PMC2481368
(2008)
Distinct TLR- and NLR-mediated transcriptional responses t oan intracellular pathogen.
PLoS Pathogens; Jan 11;4(1):e6. PMCID: PMC2186359
(2008)
A bacterial pore-forming toxin forms aggregates in cells that resemble those associated with neurodegenerative diseases.
Cell Microbiol. 2008 Apr;10(4):985-93. Epub 2007 Dec 6. PMID: 18067608
(2008)
2007
Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease.
J. Immunol. 2007 Dec 1; 179(11):7376-84. PMID: 18025181
(2007)
Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.
Infect. Immun. 2007 Nov;75(11):5135-47. PMCID: PMC2168281
(2007)
“Listeria monocytogenes.” (Chapter)
In: Harrison’s Principles of Internal Medicine, 17th Edition.
(2007)
Listeriolysin O: a phagosome-specific lysin.
Review. Microbes Infect. Aug;9(10):1176-87. Epub 2007 May 7. PMID: 17720603
(2007)
Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system.
PLoS Pathog. 2007 Mar;3(3):e51. PMCID: PMC1839167
(2007)
2006
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Infect. Immun. 2006 Nov;74(11):6387-97. PMCID: PMC1695486
(2006)
Gram-Positive Pathogens. (Text)
ASM Press. Washington, DC.
(2006)
Listeria monocytogenes traffics from the maternal organs to the placenta and back.
PLoS Pathog. 2006 Jun;2(6):e66. Erratum in PLoS Pathog. 2006 Jul;2(7):e80. PMCID: PMC1483233
(2006)
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Nat Immunol. 2006 Feb;7(2):156-64. PMID: 16415873
(2006)
Phosphorylation, ubiquitination, and degradation of Listeriolysin O in mammalian cells: role of the PEST-like sequence.
Cell. Microbiol. 2006 Feb;8(2):353-64. PMID: 16441444
(2006)
2005
Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen.
Proc. Natl. Acad. Sci. U S A 2005 Sep 20;102(38):13646-51. PMCID: PMC1224656
(2005)
Killed but metabolically active (KBMA) microbes: a new vaccine paradigm for eliciting effector T cell responses and protective immunity.
Nat. Med. 2005 Aug;11(8):853-60. PMID: 16041382
(2005)
Growth of Listeria monocytogenes in the guinea pig placenta and the role of cell-to-cell spread in fetal infection.
J. Inf. Dis. 2005 Jun 1;191(11):1889-97. PMID: 15871123
(2005)
Manipulation of innate immunity by bacterial pathogens.
Curr. Opin. Immunol. 2005 Feb;17(1):25-8. PMID: 15653306
(2005)
2004
Listeria-based cancer vaccines that segregate immunogenicity from toxicity.
Proc. Natl. Acad. Sci. U S A 2004 Sep 21;101(38):13832-7. PMCID: PMC518841
(2004)
Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.
J. Exp. Med. 2004 Aug 16;200(4):527-33. PMCID: PMC2211930
(2004)
A specific gene expression program triggered by Gram-positive bacteria in the cytosol.
Proc. Natl. Acad. Sci. U S A. 2004 Aug 3;101(31):11386-91. Epub 2004 Jul 21. PMCID: PMC509177
(2004)
Listeriosis in the pregnant guinea pig: a model of vertical transmission.
Infect. Immun. 2004 Jan;72(1):489-97. PMCID: PMC343973
(2004)
2003
Listeria monocytogenes mutants that fail to compartmentalize listeriolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses.
Infect. Immun. 2003 Dec;71(12):6754-65. PMCID: PMC308949
(2003)
Drosophila S2 cells: an alternate infection model for Listeria monocytogenes.
Cell. Microbiol. 2003 Dec;5(12):875-85. PMID: 14641173
(2003)
Listeria intracellular growth and virulence require host-derived lipoic acid.
Science. 2003 Oct 17;302(5644):462-4. PMID: 14564012
(2003)
SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis.
Proc. Natl. Acad. Sci. U S A. 2003 Oct 14;100(21):12432-7. PMCID: PMC218775
(2003)
Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of actin-based motility.
Mol. Microbiol. 2003 Sep;49(5):1361-75. PMID: 12940993
(2003)
2002
Inducible control of virulence gene expression in Listeria monocytogenes: temporal requirement of listeriolysin O during intracellular infection.
J Bacteriol. 2002 Nov;184(21):5935- 45. PMCID: PMC135386
(2002)
Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.
Proc. Natl. Acad. Sci. U S A. 2002 Oct 15;99(21):13861-6. PMCID: PMC129788
(2002)
The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity.
Review. J. Cell Biol. 2002 Aug 5;158(3):409-14. PMCID: PMC2173830
(2002)
The host cytosol: front-line or home front?
Review. Trends Microbiol. 10:361-364. PMID: 12160633
(2002)
Identification of a second Listeria secA gene associated with protein secretion and the rough phenotype.
Mol. Microbiol. 2002 Aug;45(4):1043-56. PMID: 12180923
(2002)
Construction, characterization, and use of two Listeria monocytogenes site-specific integration vectors.
J. Bacteriol. 2002 Aug;184:4177-86. Erratum in J. Bacteriol. 2003 Feb;185(4):1484. PMCID: PMC135211
(2002)
The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize its activity and prevent damage to infected host cells.
J. Cell Biol. 002 Mar 18;156(6):1029-38. PMCID: PMC2173464
(2002)
Microbial pathogenesis and the eukaryotic cytoskeleton at the American Society for Cell Biology annual meeting.
Cell. Microbiol. 2002 Mar;4(3):187-90. PMID: 11906455
(2002)
2001
Systematic mutational analysis of the amino terminal domain of the Listeria monocytogenes ActA protein reveals novel functions in actin-based motility.
Mol. Microbiol. 2002 Dec;42(5):1163-77. NIHMS ID: NIHMS73991
(2001)
Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation and Listeria monocytogenes motility.
J. Cell Biol. 2001 Oct 1;155(1):89-100. PMCID: PMC2150787
(2001)
Development of a competitive index assay to evaluate the virulence of Listeria monocytogenes ActA mutants during primary and secondary infection of mice.
Infect. Immun. 2001 Sep;69(9):5953-7. PMCID: PMC98721
(2001)
2000
A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity.
Science. 2000 Nov 3;290(5493):992-5. PMID: 11062133
(2000)
Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and L. monocytogenes motility.
J. Cell Biol. 2000 Aug 7;150(3):527-38. PMCID: PMC2175181
(2000)
“The cell biology of invasion and intracellular growth by Listeria monocytogenes.”
pp. 507-15. In: Gram-Positive Pathogens. Fischetti VA, Novick RP, Ferretti JJ, Portnoy DA, and Rood JI, editors. ASM Press. Washington, DC.
(2000)
Gram-Positive Pathogens. (Text)
ASM Press. Washington, DC.
(2000)
Role of listeriolysin O in the cell-to-cell spread of Listeria monocytogenes.
Infect. Immun. 2000 Feb;68(2):999-1003. PMCID: PMC97240
(2000)
1999
Stability of the Listeria monocytogenes ActA protein in mammalian cells is regulated by the N-end rule pathway.
Cell. Microbiol. 1999 Nov;1(3):249-57. PMID: 11207557
(1999)
Delivery of protein to the mammalian cell cytosol using Escherichia coli expressing listeriolysin O. Mol. Microbiol.
Mol. Microbiol. 1999 Mar;31(6):1631-41. PMID: 10209738
(1999)
Expression of listeriolysin O and ActA by intracellular and extracellular Listeria monocytogenes.
Infect. Immun. 1999 Jan;67(1):131-9. PMCID: PMC96288
(1999)
1998
Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth.
Infect. Immun. 1998 Aug;66(8):3552-61. PMCID: PMC108386
(1998)
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.
Science. 1998 Jul;281(5373):105-8. PMID: 9651243
(1998)
Bacterial delivery of DNA evolves.
Nat. Biotechnol. 1998 Feb;16(2):138-9. PMID: 9487514
(1998)
1997
“Pathogenic mechanisms of a model intracellular pathogen: how Listeria monocytogenes grows in cells.”
In: New approaches to intracellular bacterial infections. Proceedings of the 9th Kurhaus Workshop on Infectious Diseases. van der Meer JWM, Michel MF, and Verbrugh HA, editors.
(1997)
How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force.
Review. Trends Microbiol. 1997 July;5(7):272-6. PMID: 9234509
(1997)
Proteolytic pathways of activation and degradation of a bacterial phospholipase C during intracellular infection by Listeria monocytogenes.
J. Cell Biol. 1997 Jun 16;137(6):1381-92. PMCID: PMC2132530
(1997)
Influenza- specific immunity induced by recombinant Listeria monocytogenes vaccines.
Vaccine. 1997 Mar;15(4):433-40. PMID: 9141215
(1997)
1996
The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin.
J. Cell Biol. 1996 Nov;135(3):647-60. PMCID: PMC2121076
(1996)
Conversion of an extracellular hemolysin into a phagosome-specific lysin which supports the growth of an intracellular pathogen.
Mol. Microbiol. 1996 Sep;21(6):1219-25. PMID: 8898390
(1996)
Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria monocytogenes.
J. Biol. Chem. 1996 Mar 29;271(13):7249-52. PMID: 8631734
(1996)
1995
The broad-range phospholipase C and a metalloprotease mediate listeriolysin O-independent escape of Listeria monocytogenes from a primary vacuole in human epithelial cells
Infect. Immun. 1995 Nov;63(11):4531-4. PMCID: PMC173647
(1995)
The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread
Infect. Immun. 1995 Nov;63(11):4231-7. PMCID: PMC173601
(1995)
Asymmetric distribution of the Listeria monocytogenes ActA protein is required and sufficient to direct actin-based motility.
Mol. Microbiol. 1995 Sep;17(5):945-51. PMID: 8596443
(1995)
“Listeria monocytogenes: A novel vaccine vector.”
pp. 317-26. In: Vaccines 95. Cold Spring Harbor Laboratory Press.
(1995)
Identification of bacterial genes that contribute to survival and growth in an intracellular environment.
Review. Trends Microbiol. 1995 Mar;3(3):83-85. PMID: 7773592
(1995)
1994
Characterization of Listeria monocytogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O.
Infect. Immun. 1994 Dec;62(12):5608-13. PMCID: PMC303309
(1994)
Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.
J. Exp. Med. 1994 Dec 1;180(6):2209-18. PMCID: PMC2191788
(1994)
“Cellular biology of Listeria monocytogenes infection.”
In: The Molecular Genetics of Bacterial Pathogenesis - A Tribute to Stanley Falkow. Miller VL, Kaper JB, Portnoy DA, and Isberg RR, editors. ASM Press, Washington, DC
(1994)
Molecular Genetics of Bacterial Pathogenesis - A Tribute to Stanley Falkow.
ASM Press. Washington, DC
(1994)
The cell biology of Listeria monocytogenes infection (escape from a vacuole).
Review. Ann NY Acad Sci 1994 Aug 15;730:15-25. Microbial Pathogenesis and Immune Response. Ades EW, Morse SA, and Rest RF, editors. PMID: 8080169
(1994)
Cytolysins from Intracellular Pathogens.
Review. Trends Microbiol. 1994 Aug;2(8):261-3. PMID: 7981967
(1994)
Dual promoters of the Listeria monocytogenes prfA transcriptional activator appear essential in vitro but are redundant in vivo.
Mol. Microbiol. 1994 Jun;12(5):845-53. PMID: 8052135
(1994)
Intracellular growth of bacteria.
Review. Methods Enzymol. 1994;236:463-7. PMID: 7968630
(1994)
Small plaque mutants.
Review. Methods Enzymol. 1994;236:526-31. PMID: 7968636
(1994)
Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts.
Cell. 1994 Feb 11;76(3):505-17. PMID: 8313471
(1994)
Phospholipases C and the pathogenesis of Listeria.
Review. Braz. J. Med. Biol. Res. 1994 Feb;27(2):357-61. PMID: 8081249
(1994)
1993
Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.
Proc. Natl. Acad. Sci. U S A. 1993 Dec 15;90(24):11890-4. PMCID: PMC48090
(1993)
Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants.
Infect. Immun. 1993 Sep;61(9):3756-60. PMCID: PMC281074
(1993)
Regulation of the Listeria monocytogenes transcriptional activator prfA: Multiple promoter elements contribute to intracellular growth and cell-to-cell spread.
Infect. Immun. 1993 Jun;61(6):2537-44. PMCID: PMC280881
(1993)
Dual roles of plcA in Listeria monocytogenes pathogenesis.
Molec. Microbiol. 1993 Apr;8(1):143-57. PMID: 8388529
(1993)
1992
"Regulation of the entry into host cytoplasm and cell-to-cell spread of Listeria monocytogenes.”
In: Molecular recognition in host-parasite interactions. Korhonen TK, Hovi T, and Makela PH, editors. Plenum Publishing Company
(1992)
“Pathogenesis of Listeria monocytogenes.”
In: Mononuclear phagocytes: biology of monocytes and macrophages. van Furth R, editor. Kluwer Academic Publishers.
(1992)
The interaction of bacteria with mammalian cells.
Review. Ann. Rev. Cell Biol. 1992;8:333-63. Review. PMID: 1476803
(1992)
Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.
J. Immunol. 1992 Jul 1;149(1):53-9. PMID: 1607662
(1992)
Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells
Infect. Immun. 1992 Jul;60(7):2710-7. PMCID: PMC257225
(1992)
Cell biology. Devious devices of Salmonella.
Nature. 1992 Jun 18;357(6379):536-7. News and Views. PMID: 1376857
(1992)
Listeriolysin O is a target of the immune response to Listeria monocytogenes.
J. Exp. Med. 1992 Jun 1;175(6):1467-71. PMCID: PMC2119232
(1992)
The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization.
Nature. 1992 May 21;357(6375):257-60. PMID: 1589024
(1992)
“Escape from the phagosome and cell-to-cell spread of Listeria monocytogenes.”
In: Microbial Adhesion and Invasion. Hook M and Switalski L, editors. Springer-Verlag Publishers.
(1992)
Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread.
Infect. Immun. 1992 Apr;60(4):1625-32. PMCID: PMC257039
(1992)
Molecular determinants of Listeria monocytogenes pathogenesis.
Review. Infect. Immun. 1992 Apr;60(4):1263-7. PMCID: PMC256991
(1992)
Trancriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis.
J. Bacteriol. 1992 Feb;174(4): 1293-1298. PMCID: PMC206424
(1992)
Innate immunity to a facultative intacellular bacterial pathogen.
Review. Curr Opin Immunol. 1992 Feb;4(1):20-4. PMID: 1596365
(1992)
1991
Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent.
J. Exp. Med. 1991 Mar 1;173(3):751-4. PMCID: PMC2118838
(1991)
1990
Actin filament nucleation by the bacterial intracellular pathogen, Listeria monocytogenes.
J. Cell Biol. 1990 Dec;111(6 Pt 2):2979-88. PMCID: PMC2116415
(1990)
Presentation of Listeria by CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.
J. Immunol. 1990 Dec 1;145(11):3540-6. PMID: 2147195
(1990)
Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread.
Infect. Immun. 1990 Nov;58(11):3770-8. PMCID: PMC313727
(1990)
Listeria monocytogenes moves rapidly through the host cell cytoplasm by inducing directional actin assembly.
Proc. Natl. Acad. Sci. U S A. 1990 Aug; 87(16):6068-72. PMCID: PMC54473
(1990)
Insertional mutagenesis of Listeria monocytogenes with a novel Tn917-derivative that allows direct cloning of DNA flanking transposon insertions.
J. Bacteriol. 1990 Jul;172(7):3738-44. PMCID: PMC213352
(1990)
Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells.
Nature. 1990 May 10; 345(6271):175-176. PMID: 2110628
(1990)
1989
Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm.
J. Exp. Med. 1989 Dec 1;170(6):2141-6. PMCID: PMC2189551
(1989)
Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
J. Cell Biol. 1989 Oct;109(4):1597-608. PMCID: PMC2115783
(1989)
Intracellular methicillin selection of Listeria monocytogenes mutants unable to replicate in a macrophage cell line.
Proc. Natl. Acad. Sci. U S A. 1989 Jul;86(14):5522-6. PMCID: PMC297655
(1989)
1988
Role of hemolysin for the intracellular growth of Listeria monocytogenes.
J. Exp. Med. 1988 Apr 1;167(4):1459-71. PMCID: 2188911
(1988)
1986
Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors.
Science. 1986 Nov 7;234(4777):718-25. PMID: 2946078
(1986)
Cloning and characterization of a mouse cysteine proteinase.
J. Biol. Chem. 1986 Nov 5;261(31):14697-703. PMID: 3533924
(1986)
1985
“Expression of foreign proteins on the surface of Xenopus laevis oocytes.”
pp. 427-38. In: Hybridoma Technology in the Biosciences and Medicine. Springer Publishers.
(1985)
Expression of the temperature-inducible outer membrane proteins of Yersinia.
Infect. Immun. 1985 Apr;48(1):234-40. PMCID: PMC261940
(1985)
Transfer of the virulence plasmid of Yersinia pestis to ersinia pseudotuberculosis.
Infect. Immun. 1985 Apr;48(1):241-3. PMCID: PMC261941
(1985)
Role of a plasmid in the pathogenicity of Yersinia species.
Review. Curr Top Microbiol Immunol. 1985;118:29-51. PMID: 3902382
(1985)
1984
Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins.
Infect. Immun. 1984 Jan;43(1):108-14. PMCID: PMC263395
(1984)
1983
Genetic analysis of essential plasmid-mediated determinants of pathogenicity in Yersinia pestis.
J. Infect. Dis. 1983 Aug;148(2):297-304. PMID: 6310003
(1983)
Bacterial plasmids -- an overview.
Review. Clin. Invest. Med. 1983;6(3):207-12. PMID: 6360456
(1983)
1981
Virulence-associated plasmids from Yersinia enterocolitica and Yersinia pestis.
J. Bacteriol. 1981 Dec 1148(3):877-83. PMCID: PMC216287
(1981)
R-factor cointegrate formation in Salmonella typhimurium bacteriophage type 201 strains.
J. Bacteriol. 1981 May;146(2): 444-52. PMCID: PMC216985
(1981)
Characterization of plasmid- associated determinants of Yersinia enterocolitica pathogenesis.
Infect. Immun. 1981 Feb;31(2):775-782. PMCID: PMC351377
(1981)