Temporal and spatial dynamics of Listeria monocytogenes central nervous system infection in mice.
Chevée V, Hullahalli K, Dailey KG, Güereca L, Zhang C, Waldor MK, Portnoy DA
Proc Natl Acad Sci U S A 2024 121 (17) e2320311121 (2024)
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Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy.
Garcia-Castillo, J, Fernandez S, Campbell T, Williams J, Gonzales-Ventura D, Ybarra J, Flores-Hernandez N, Wells E, Portnoy DA, DuPage M.
bioRxiv doi: (2024)
bioRxiv Abstract |


Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as a source of essential L-cysteine.
Berude, JC, Kennouche P, Reniere ML, Portnoy DA
Infect Immun. 2024 Jan 30:e0042223. doi: 10.1128/iai.00422-23. Online ahead of print. PMID: 38289071 (2024)
PubMed Abstract | Full Text



The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine.
Feng Y, Chang SK, Portnoy DA.
mBio. 11 Sep 2023: e0107423. doi: 10.1128/mbio.01074-23. Online ahead of print. Editor's Pick. (2023)
PubMed Abstract | Full Text


Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
Morrison HM, Craft J, Rivera-Lugo R, Johnson JR, Golovkine GR, Bell SL, Dodd CE, Van Dis E, Beatty WL, Margolis SR, Repasy T, Shaker I, Lee AY, Vance RE, Stanley SA, Watson RO, Krogan NJ, Portnoy DA, Penn BH, Cox JS.
PLoS Pathog. 2023 Jun 23;19(6): e1011088. doi: 10.1371/journal.ppat.1011088. Online ahead of print. PMCID: PMC10325092 (2023)
PubMed Abstract | Full Text


Distinct energy-coupling factor transporter subunits enable flavin acquisition and extracytosolic trafficking for extracellular electron transfer in Listeria monocytogenes.
Rivera-Lugo R, Huang S, Lee F, Méheust R, Iavarone AT, Sidebottom AM, Oldfield E, Portnoy DA, Light SH.
mBio. 2023 Feb 28;14(1):e0308522. doi: 10.1128/mbio.03085-22. Epub 2023 Feb 6. PMCID: PMC9973259 (2023)
PubMed Abstract | Full Text



para-Aminobenzoic acid biosynthesis is required for Listera monocytogenes growth and pathogenesis.
Zhang Y, Anaya-Sanchez A, Portnoy DA.
Infect Immun. 2022 Nov 17:90(11):e0020722. Doi: 10.1128/iai.00207-22. Epub 2022 Nov 1. PMCID: PMC9670987 (2022)
PubMed Abstract | Full Text


Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis.
Rivera-Lugo R, Deng D, Anaya-Sanchez A, Tejedor-Sanz S, Tang E, Reyes Ruiz VM, Smith HB, Titov DV, Sauer JD, Skaar EP, Ajo-Franklin CM, Portnoy DA, Light SH.
Elife. 2022 Apr 5;11:e75424. Doi: 10.7554/eLife.75424. PMID: 35380108. (2022)
PubMed Abstract | Full Text


RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth.
Rivera-Lugo R, Light SH, Garelis NE, Portnoy DA
Proc Natl Acad Sci USA. 2022 Mar 29;119(13):e2122173119. doi: 10.1073/pnas.2122173119. Epub 2022 Mar 22. PMID 35316134 (2022)
PubMed Abstract | Full Text



Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes
Anaya Sanchez A, Feng Y, Berude J, Portnoy DA
PLOS Pathogens: 2021 Aug 18:17(8):e1009819. doi: 10.1371/journal.ppat.1009819. PMCID: PMC8372916 (2021)
PubMed Abstract | Full Text



Secretion of c-di-AMP by Listeria monocytogenes leads to a STING-dependent antibacterial response during enterocolitis.
Louie A, Bhandula V, Portnoy DA
Infect Immun. 2020 Oct 5:IAI.00407-20. doi: 10.1128/IAI.00407-20. PMID: 33020211 (2020)
PubMed Abstract | Full Text


Secondary structure of the mRNA encoding listeriolysin O is essential to establish the replicative niche of L. monocytogenes.
Peterson BN, Portman JL, Feng Y, Wang J, Portnoy DA.
Proc Natl Acad Sci - USA. (2020)
PubMed Abstract | Full Text


(p)ppGpp and ci-di-AMP homeostasis is controlled by CbpB in Listeria monocytogenes.
Peterson BN, Young MKM, Luo S, Wang J, Whiteley AT, Woodward JJ, Tong L, Wang JD, Portnoy DA.
mBio. 2020 Aug 25;11(4):e01625-20. doi: 10.1128/mBio.01625-20. PMID: 32843560 (2020)
PubMed Abstract | Full Text


TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes.
Nguyen BN, Chavez-Arroyo A, Louie A, Cheng MI, Krasilnikov M, Portnoy DA.
PLoS Pathog. 2020 Jul 7;16(7):e1008622. doi: 10.1371/journal.ppat.1008622. eCollection 2020 Jul. PMCID: PMC7340287 (2020)
PubMed Abstract | Full Text


The nonmevalonate pathway of isoprenoid biosynthesis supports anaerobic growth of Listeria monocytogenes.
Lee ED, Navas KI, Portnoy DA.
Infect Immun. 2020 Jan 22;88(2). doi: 10.1128/IAI.00788-19. PMCID: PMC6977116 (2020)
PubMed Abstract | Full Text


Why is Listeria monocytogenes such a potent inducer of CD8+ T-cells?
Chavez-Arroyo A, Portnoy DA.
Cell Microbiol. 2020 April 22(4):e13175. Doi: 10.1111/cmi.13175. Review. PMCID: PMC100999 (2020)
PubMed Abstract | Full Text


An Inducible Cre-lox System to Analyze the Role of LLO in Listeria monocytogenes Pathogenesis
Nguyen BN, Portnoy DA
Toxins. 2020 Jan 7 12(1) doi: 10.3390/toxins12010038. PMCID: PMC7020504 (2020)
PubMed Abstract | Full Text



A multiorgan trafficking circuit provides purifying selection of Listeria monocytogenes virulence genes.
Louie A, Zhang T, Becattini S, Waldor MK, Portnoy DA
mBio. 2019 Dec 17;10(6). pii: e02948-19. doi: 10.1128/mBio.02948-19. PMID: 31848289 (2019)
PubMed Abstract | Full Text


Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria.
Light SH, Méheust R, Ferrell JL, Cho J, Dang D, Agostoni M, Iavarone AT, Banfield JF, D’Orazio SEF, Portnoy DA.
Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 201915678. doi: 10.1073/pnas.1915678116. [Epub ahead of print] PMID: 31818955 (2019)
PubMed Abstract | Full Text


A potent and effective suicidal Listeria vaccine platform.
Hanson WG, Benanti EL, Lemmens EE, Liu W, Skoble J, Leong ML, Rae CS, Fasso M, Brockstedt DG, Chen C, Portnoy DA, Dubensky Jr TW, Lauer P.
Infect Immun. 2019 Jul 23;87(8) pii: e00144-19. doi: 10.1128/IAI.00144-19. Print 2019 Aug. PMCID: PMC6652770 (2019)
PubMed Abstract | Full Text



Listeriolysin O: a phagosome-specific cytolysin revisited.
Nguyen BN, Peterson BN, Portnoy DA.
Cell Microbiol. Dec 4:312988. Doi: 10.1111/cmi.12988. [Epub ahead of print]. Review. NIHMS1515399 (2018)
PubMed Abstract | Full Text


A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria.
Light SH, Su L, Rivera-Lugo R, Cornejo JA, Louie A, Iavarone AT, Ajo-Franklin CM, Portnoy DA.
Nature. 2018 Sep 12. doi: 10.1038/s41586-018-0498-z. [Epub ahead of print] PMCID: PMC6221200 (2018)
PubMed Abstract | Full Text


Recombinant Listeria promotes tumor rejecton by CD8+ T cell-dependent remodeling of the tumor microenvionment.
Deng W, Lira V, Hudson T, Lemmens EE, Hanson WG, Flores R, Barajas G, Katibah GE, Desbien AL, Lauer P, Leong ML, Portnoy DA, Dubensky Jr. TW.
Proc Natl Acad Sci USA. July 23, 2018. 201801910. doi: 10.1073/pnas.1801910115. [Epub ahead of print] PMCID: PMC6094133 (2018)
PubMed Abstract | Full Text


The listeriolysin O PEST-like sequence prevents plasma membrane damage during Listeria infection by promoting AP-2-mediated endocytosis.
Chen C, Nguyen BN, Mitchell G, Margolis SR, Ma D, Portnoy DA.
Cell Host Microbe. 13 June 2018. 23:786-795.e5. doi: 10.1016/j.chom.2018.05.006. PMCID: PMC6007032 (2018)
PubMed Abstract | Full Text


Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol.
Cheng MI, Chen C, Engström P, Portnoy DA, Mitchell G.
Cellular Microbiol. 2018 May 3:e12854. doi: 10.1111/cmi.12854. [Epub ahead of print] PMID: 29726107 (2018)
PubMed Abstract | Full Text


STING-activating adjuvants elicit a Th17 immune response and protect against Mycobacterium tuberculosis infection.
Van Dis E, Sogi KM, Rae CS, Sivick KE, Surh NH, Leong ML, Kanne DB, Metchette K, Leong JJ, Brumi JR, Chen V, Heydari K, Cadieux, Evans T, McWhirter SM, Dubensky Jr. TW, Portnoy DA, Stanley SA.
Cell Rep. 2018 May 1;23(5):1435-1447. doi: 10.1016/j.celrep.2018.04.003. PMID: 29719256 (2018)
PubMed Abstract | Full Text


Listeria monocytogenes triggers non-canonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy.
Mitchell G, Cheng MI, Chen C, Nguyen BN, Whiteley AT, Kianian S, Cox JS, Green DR, McDonald KL, Portnoy DA.
Proc Natl Acad Sci U S A 115(2): E210-E217. doi: 10.1073/pnas.1716055115. Epub 2017 Dec 26 (2018)
PubMed Abstract | Full Text



Activation of the Listeria monocytogenes virulence program by a reducing environment.
Portman JL, Dubensky SB, Peterson BN, Whiteley AT, Portnoy DA
mBio. 8(5): doi: 10.1128/mBio.01595-17 17 October 2017 mBio e01595-17. PMCID: PMC5646252 (2017)
PubMed Abstract | Full Text


Identification of Coxiella burnetti CD8+ epitopes and delivery by attenuated Listeria monocytogenes as a vaccine vector in a C57BL/6 mouse model.
Xiong X, Jiao J, Gregory AE, Wang P, Bi Y, Wang X, Jiang Y, Wen B, Portnoy DA, Samuel JE, Chen C.
J Infect Dis. 2017 May 15;215(10):1580-1589. doi: 10.1093/infdis/jiw470. NIHMSID: 841238 (2017)
PubMed Abstract | Full Text


c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance, and osmoregulation.
Whiteley AT, Garelis NE, Peterson BN, Choi PH, Tong L, Woodward JJ, Portnoy DA.
Mol Microbiol. 2017 Apr;104(2):212-233. doi: 10.1111/mmi.13622. Epub 2017 Mar 8. PMCID: PMC5391996 (2017)
PubMed Abstract | Full Text


Activity of the pore-forming virulence factor Listeriolysin O is reversibly inhibited by naturally occuring S-glutathionylation.
Portman JL, Huang Q, Reniere ML, Iavarone AT, Portnoy DA.
Infect Immun. 2017 Mar 23;85(4). pii: e00959-16. doi: 10.1128/IAI.00959-16. Print 2017 Apr. PMCID: PMC5364301 (2017)
PubMed Abstract | Full Text


Listening to each other: infectious disease and cancer immunology.
Vance RE, Eichberg MJ, Portnoy DA, Raulet DH.
Sci. Immunol. 2, eaai9339 13 Jan 2017. doi: 10.1126/sciimmunol.aai9339. (2017)
PubMed Abstract | Full Text



An in vivo selection to identify how Listeria monocytogenes recognizes the intracellular environment.
Reniere ML, Whiteley AT, Portnoy DA.
PLoS Pathog. 2016 Jul 14;12(7):e1005741. doi: 10.1371/journal.ppat.1005741. eCollection 2016 Jul. PMCID: PMC4945081 (2016)
PubMed Abstract | Full Text


SpoVG is a conserved RNA-binding protein that regulates Listeria monocytogenes lysozyme resistance, virulence, and swarming motility.
Burke TP and Portnoy DA.
MBio. 2016 Apr 5;7(2). Pii: e00240-16. doi: 10.1128/mBio.00240-16. PMCID: PMC4959528 (2016)
PubMed Abstract | Full Text



Ribosome hibernation facilitates tolerance of stationary-phase bacteria to aminoglycosides.
McKay SL and Portnoy DA.
Antimicrob Agents Chemother. 2015 Nov;59(11):6992-9. doi: 10.1128/AAC.01532-15. Epub 2015 Aug 31. PMCID: PMC4604360 (2015)
PubMed Abstract | Full Text


Strategies used by bacteria to grow in macrophages.
Mitchell G*, Chen C*, Portnoy DA. (* contributed equally)
Book chapter in: Myeloid Cells in Health and Disease: A Synthesis. ASM Press. PMCID: PMC4922531 (2015)
PubMed Abstract | Full Text


The PAMP c-di-AMP is essential for Listeria monocytogenes growth in rich but not minimal media, due to a toxic increase in (p)ppGpp.
Whiteley AT, Pollock AJ, Portnoy DA.
Cell Host Microbe. 2015 Jun 10;17(6):788-98. doi: 10.1016/j.chom.2015.05.006. Epub 2015 May 28. PMCID: PMC4469362 (2015)
PubMed Abstract | Full Text


RNA-based fluorescent biosensors for live cell imaging of second messenger cyclic di-AMP.
Kellenberger CA, Chen C, Whiteley AT, Portnoy DA, Hammond MC.
J Am Chem Soc. 2015 May 27;137(20):6432-5. Doi: 10.1021/jacs.5b00275. EPub 2015 May 15. PMCID: PMC4521591 (2015)
PubMed Abstract | Full Text


Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages.
Mitchell G, Ge L, Huang Q, Chen C, Kianian S, Roberts M, Schekman R, Portnoy DA.
Infect Immun. 2015 May;83(5):2175-84. PMID 25776746. PMCID: PMC4399067 (2015)
PubMed Abstract | Full Text


STING agonist formulated cancer vaccines can cure established tumor resistant to PD-1 blockade.
Fu J, Kanne DB, Leong M, Hix Glickman L, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, Woodward JJ, Pardoll DM, Dubensky Jr TW, Kim Y.
Sci Transl Med. 2015 Apr 15;7(283):283ra52. doi: 10.1126/scitranslmed.aaa4306. PMCID: PMC4504692 (2015)
PubMed Abstract | Full Text


Host actin polymerization tunes the cell division cycle of an intracellular pathogen.
Siegrist MS, Aditham A, Espaillat A, Cameron T, Whiteside S, Cava F, Portnoy DA, Bertozzi CR.
Cell Rep. 2015 Apr 15. pii: S2211-1247(15)00325-3. doi: 10.1016/j.celrep.2015.03.046. [Epub ahead of print] PMCID: PMC4417095 (2015)
PubMed Abstract | Full Text


A prl mutation in secY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutants.
Durack J, Burke TP, Portnoy DA.
J. Bacteriol. 2015 Mar;197(5):932-42. doi: 10.1128/JB.02284-14. Epub 2014 Dec 22. PMCID: PMC4325107 (2015)
PubMed Abstract | Full Text


The Listeria monocytogenes hibernation-promoting factor (HPF) is required for the formation of 100S ribosomes, optimal fitness, and pathogenesis.
Kline B, McKay S, Tang W, Portnoy DA.
J Bacteriol. 2015 Feb 1;197(3):581-91. doi: 10.1128/JB.02223-14. Epub 2014 Nov 24. PMCID: PMC4285973 (2015)
PubMed Abstract | Full Text


Glutathione activates virulence gene expression of an intracellular pathogen. Article.
Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA.
Nature. 2015 Jan 8:517(7533):170-3. doi: 10.1038/ nature14029. PMCID: PMC4305340 (2015)
PubMed Abstract | Full Text



Listeria monocytogenes is resistant to lysozyme through the regulation, not acquisition, of cell wall modifying enzymes.
Burke TP, Loukitcheva A, Zemansky J, Wheeler R, Boneca IG, Portnoy DA.
J. Bacteriol. 2014 Nov;196(21):3756-67. doi: 10.1128/JB.02053-14. Epub 2014 Aug 25. PMCID: PMC4248804 (2014)
PubMed Abstract | Full Text


Comparison of widely used Listeria monoctyogenes strains EGD, 10403S, and EGD-e highlights genomic differences underlying variations in pathogenicity.
Bécavin C, Bouchier C, Lechat P, Archambaud C, Creno S, Gouin E, Wu Z, Kübacher A, Brisse S, Pucciarelli MG, García-del Portillo F, Hain T, Portnoy DA, Chakraborty T, Lecuit M, Pizarro-Cerdá J, Moszer I, Bierne H, Cossart P.
mBio. 2014 Mar 25;5(2):e00969-14.5(2): doi:10.1128/mBio.00969-14. PMCID: PMC3977354 (2014)
PubMed Abstract | Full Text


STING-dependent Type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes.
Archer KA, Durack J, and Portnoy DA.
PLoS Pathog. 2014 Jan;10(1):e1003861. doi: 10.1371/journal.ppat.1003861. Epub 2014 Jan 2. PMCID: PMC3879373 (2014)
PubMed Abstract | Full Text



Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection.
Witte CE, Whiteley AT, Burke TP, Sauer, JD, Portnoy DA, Woodward JJ.
. mBio. 2013 May 28;4(3). Doi:pii:e00282-13. 1128/mBio.00282-13. PMCID: PMC3663569 (2013)
PubMed Abstract | Full Text



Development of single-gene, signature-tag-based approach in combination with alanine mutagenesis to identify listeriolysin O residues critical for the in vivo survival of Listeria monocytogenes.
Melton-Witt JA, McKay SL, Portnoy DA.
Infect Immun. 2012 Jun;80(6):2221-30. PMCID: PMC3370594 (2012)
PubMed Abstract | Full Text


Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.
Manzanillo PS, Shiloh MU, Portnoy DA, Cox JS.
Cell Host & Microbe. May 17, 2012: 11:469-480. PMCID: PMC3662372 (2012)
PubMed Abstract | Full Text


Yogi Berra, Forrest Gump, and the discovery of Listeria actin comet tails. Review.
Portnoy DA.
Mol Biol Cell. 2012 Apr;23(7):1141-5. Review. PMCID: PMC3376002 (2012)
PubMed Abstract | Full Text


Hyper-induction of host interferon β by a Listeria monocytogenes strain naturally over-expressing the multi-drug efflux pump MdrT.
Schwartz KT, Carleton JD, Quillin SJ, Rollins SD, Portnoy DA, Leber JH.
Infect Immun. 2012 Apr;80(4):1537-45. Epub 2012 Jan 30. PMCID: PMC3318417 (2012)
PubMed Abstract | Full Text


Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs.
Melton-Witt JA, Rafelski SM, Portnoy DA, Bakardjiev AI.
Infect Immun. 2012 Feb;80(20):730-32. Epub 2011 Nov 14. PMCID: PMC3264322 (2012)
PubMed Abstract | Full Text


Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity.
Witte CE, Archer KA, Rae CS, Sauer JD, Woodward JJ, Portnoy DA.
Review. Adv. Immunol. 2012;113:135-56. PMID: 22244582 (2012)
PubMed Abstract | Full Text



Post-translocation chaperone PrsA2 regulates the maturation and secretion of Listeria monocytogenes proprotein virulence factors.
Forster BM, Zemansky J, Portnoy DA, and Marquis H.
J. of Bacteriol. Nov;193(21):5961-70. Epub 2011 Sep 9. PMCID: PMC3194926 (2011)
PubMed Abstract | Full Text


Mutations of the Listeria monocytogenes peptidoglycan N-deacetylase and O-acetylase result in enhanced lysozyme sensitivity, bacteriolysis and hyper-induction of innate immune pathways.
Rae CS, Geissler A, Adamson PC, Portnoy DA.
Infect Immun. 2011 Sept;79(9);3596-606 Epub 2011 Jul 18. PMCID: PMC3165460 (2011)
PubMed Abstract | Full Text


Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.
Sauer JD, Peryere S, Archer KA, Hanson B, Lauer P, Portnoy DA.
Proc Natl Acad Sci USA. Jul 26;108(30):12419-24. Epub 2011 Jul 11. PMCID: PMC3145703 (2011)
PubMed Abstract | Full Text


Dynamic imaging of the effector immune response to Listeria infection in vivo.
Waite JC, Leiner I, Lauer P, Rae CS, Barbet G, Zheng H, Portnoy DA, Pamer EG, Dustin ML.
PLoS Pathog. 2011 Mar;7(3):e1001326. Epub 2011 Mar 24 2011. PMCID: PMC3063765 (2011)
PubMed Abstract | Full Text


The N-ethyl-N-nitrosourea-induced Goldenticket (Gt) mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.
Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE.
Infect Immun. 2011 Feb;79(2):688-94. Epub 2010 Nov 22. PMCID: PMC3028833 (2011)
PubMed Abstract | Full Text



c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.
Woodward JJ, Iavarone AT, Portnoy DA.
Science. 2010 Jun 25;328(5986): 1703-5. Epub 2010 May 27. PMCID: PMC3156580 (2010)
PubMed Abstract | Full Text


Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.
Sauer JD, Witte CE, Zemansky J, Hanson B, Lauer P, and Portnoy DA.
Cell Host Microbe. 2010 May 20;7(5):412-9. Epub 2010 Apr 22. PMCID: PMC2947455 (2010)
PubMed Abstract | Full Text


Listeriolysin O is necessary and sufficient to induce autophagy during Listeria monocytogenes infection.
Meyer-Morse N, Robbins JR, Rae CS, Mochegova SN, Swanson MS, Zhao Z, Virgin HW, Portnoy D.
PLoS One. 2010 Jan 6:5(1). PMCID: PMC2797616 (2010)
PubMed Abstract | Full Text



Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria.
Bahjat KS, Meyer-Morse N, Lemmens EE, Shugart JA, Dubensky TW, Brockstedt DG, and Portnoy DA.
PLoS Pathog. 2009 Sep;5(9):e1000568. Epub 2009 Sep 4. PMCID: PMC2731223 (2009)
PubMed Abstract | Full Text


Listeria monocytogenes 6-phosphogluconolactonase (pgl) mutants induce increased activation of a host cytosolic surveillance pathway.
Crimmins GT, Schelle MW, Herskovits AA, Ni PP, Kline BC, Meyer-Morse N, Iavarone AT, and Portnoy DA.
Infect Immun., 2009 Jul;77(7):3014-22. PMCID: PMC2708561 (2009)
PubMed Abstract | Full Text


Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.
Vance RE, Isberg RR, Portnoy DA.
Review. Cell Host Microbe. 2009 Jul 23;6(1):10-21. PMCID: PMC 2777727 (2009)
PubMed Abstract | Full Text


Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-proline isomerase, PrsA2, that contribute to its hemolytic phenotype.
Zemansky J, Kline BC, Woodward JJ, Leber JH, Marquis H, and Portnoy DA.
J Bacteriol. 2009 Jun;191(12):3950-64. EPub 2009 Apr 17. PMCID: PMC2698408 (2009)
PubMed Abstract | Full Text


Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax.
Skoble J, Beaber JW, Gao Y, Lovchik JA, Sower LE, Liu W, Luckett W, Peterson JW, Calendar R, Portnoy DA, Lyons CR, Dubensky TW Jr.
Infect Immun. 2009 Apr;77(4):1649-63. Epub 2009 Jan 21. PMCID: PMC2663168 (2009)
PubMed Abstract | Full Text



Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity.
Crimmins GT, Herskovits AA, Rehder K, Sivick KE, Lauer P, Dubensky TW Jr, and Portnoy DA.
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10191-6. Epub 2008 Jul 16. PMCID: PMC2481368 (2008)
PubMed Abstract | Full Text


Distinct TLR- and NLR-mediated transcriptional responses t oan intracellular pathogen.
Leber JH, GT Crimmins, Raghavan S, Meyer-Morse NP, Cox JS, and Portnoy DA.
PLoS Pathogens; Jan 11;4(1):e6. PMCID: PMC2186359 (2008)
PubMed Abstract | Full Text


A bacterial pore-forming toxin forms aggregates in cells that resemble those associated with neurodegenerative diseases.
Viala JP, Mochegova SN, Meyer-Morse N, and Portnoy DA.
Cell Microbiol. 2008 Apr;10(4):985-93. Epub 2007 Dec 6. PMID: 18067608 (2008)
PubMed Abstract | Full Text



Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease.
Bahjat KS, Prell RA, Allen HE, Liu W, Lemmens EE, Leong ML, Portnoy DA, Dubensky TW Jr, Brockstedt DG, Giedlin MA.
J. Immunol. 2007 Dec 1; 179(11):7376-84. PMID: 18025181 (2007)
PubMed Abstract | Full Text


Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.
Schnupf P, Zhou J, Varshavsky A, and Portnoy DA.
Infect. Immun. 2007 Nov;75(11):5135-47. PMCID: PMC2168281 (2007)
PubMed Abstract | Full Text


“Listeria monocytogenes.” (Chapter)
Hohmann EL and Portnoy DA.
In: Harrison’s Principles of Internal Medicine, 17th Edition. (2007)


Listeriolysin O: a phagosome-specific lysin.
Schnupf P and Portnoy DA.
Review. Microbes Infect. Aug;9(10):1176-87. Epub 2007 May 7. PMID: 17720603 (2007)
PubMed Abstract | Full Text


Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system.
Herskovits, AA, Auerbuch V, and Portnoy DA.
PLoS Pathog. 2007 Mar;3(3):e51. PMCID: PMC1839167 (2007)
PubMed Abstract | Full Text



Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Bahjat KS, Liu W, Lemmens EE, Schoenberger SP, Portnoy DA, Dubensky TW Jr, and Brockstedt DG.
Infect. Immun. 2006 Nov;74(11):6387-97. PMCID: PMC1695486 (2006)
PubMed Abstract | Full Text


Gram-Positive Pathogens. (Text)
Fischetti VA, Novick RP, Ferretti JJ, Portnoy DA, Rood JI, editors.
ASM Press. Washington, DC. (2006)


Listeria monocytogenes traffics from the maternal organs to the placenta and back.
Barardjiev AI, Theriot JA, and Portnoy DA.
PLoS Pathog. 2006 Jun;2(6):e66. Erratum in PLoS Pathog. 2006 Jul;2(7):e80. PMCID: PMC1483233 (2006)
PubMed Abstract | Full Text


The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Tabeta K, Hoebe K, Janssen EM, Du X, George P, Crozat K, Mudd S, Mann N, Sovath S, Goode J, Shamel L, Herskovits AA, Portnoy DA, Cooke M, Tarantino LM, Wiltshire T, Steinberg BE, Grinstein S, and Beutler B.
Nat Immunol. 2006 Feb;7(2):156-64. PMID: 16415873 (2006)
PubMed Abstract | Full Text


Phosphorylation, ubiquitination, and degradation of Listeriolysin O in mammalian cells: role of the PEST-like sequence.
Schnupf P, Portnoy DA, and Decatur AL.
Cell. Microbiol. 2006 Feb;8(2):353-64. PMID: 16441444 (2006)
PubMed Abstract | Full Text



Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen.
Cheng LW, Viala JP, Stuurman N, Wiedemann U, Vale RD, and Portnoy DA.
Proc. Natl. Acad. Sci. U S A 2005 Sep 20;102(38):13646-51. PMCID: PMC1224656 (2005)
PubMed Abstract | Full Text


Killed but metabolically active (KBMA) microbes: a new vaccine paradigm for eliciting effector T cell responses and protective immunity.
Brockstedt DG, Bahjat KS, Giedlin MA, Liu W, Leong M, Luckett W, Gao Y, Schnupf P, Kapadia D, Castro G, Sampson-Johannes A, Herskovits AA, Stassinopoulos A, Bouwer HG, Hearst JE, Portnoy DA, Cook DN, and Dubensky TW Jr.
Nat. Med. 2005 Aug;11(8):853-60. PMID: 16041382 (2005)
PubMed Abstract | Full Text


Growth of Listeria monocytogenes in the guinea pig placenta and the role of cell-to-cell spread in fetal infection.
Bakardjiev AI, Stacy BA, and Portnoy DA.
J. Inf. Dis. 2005 Jun 1;191(11):1889-97. PMID: 15871123 (2005)
PubMed Abstract | Full Text


Manipulation of innate immunity by bacterial pathogens.
Portnoy DA.
Curr. Opin. Immunol. 2005 Feb;17(1):25-8. PMID: 15653306 (2005)
PubMed Abstract | Full Text



Listeria-based cancer vaccines that segregate immunogenicity from toxicity.
Brockstedt, DG, Giedlin MA, Leong ML, Bahjat KS, Gao Y, Luckett Y, Liu W, Cook DN, Portnoy DA, and Dubensky TW Jr.
Proc. Natl. Acad. Sci. U S A 2004 Sep 21;101(38):13832-7. PMCID: PMC518841 (2004)
PubMed Abstract | Full Text


Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.
Auerbuch V, Brockstedt DG, Meyer-Morse N, O’Riordan M, and Portnoy DA.
J. Exp. Med. 2004 Aug 16;200(4):527-33. PMCID: PMC2211930 (2004)
PubMed Abstract | Full Text


A specific gene expression program triggered by Gram-positive bacteria in the cytosol.
McCaffrey RL, Fawcett P, O’Riordan M, Lee KD, Havell EA, Brown PO, and Portnoy DA.
Proc. Natl. Acad. Sci. U S A. 2004 Aug 3;101(31):11386-91. Epub 2004 Jul 21. PMCID: PMC509177 (2004)
PubMed Abstract | Full Text


Listeriosis in the pregnant guinea pig: a model of vertical transmission.
Bakardjiev AI, Stacy BA, Fisher SJ, Portnoy DA.
Infect. Immun. 2004 Jan;72(1):489-97. PMCID: PMC343973 (2004)
PubMed Abstract | Full Text



Listeria monocytogenes mutants that fail to compartmentalize listeriolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses.
Glomski IJ, Decatur AL, and Portnoy DA.
Infect. Immun. 2003 Dec;71(12):6754-65. PMCID: PMC308949 (2003)
PubMed Abstract | Full Text


Drosophila S2 cells: an alternate infection model for Listeria monocytogenes.
Cheng LW and Portnoy DA.
Cell. Microbiol. 2003 Dec;5(12):875-85. PMID: 14641173 (2003)
PubMed Abstract | Full Text


Listeria intracellular growth and virulence require host-derived lipoic acid.
O’Riordan M., Moors MA, and Portnoy DA.
Science. 2003 Oct 17;302(5644):462-4. PMID: 14564012 (2003)
PubMed Abstract | Full Text


SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis.
Lenz LL, Mohammadi S, Geissler A, and Portnoy DA.
Proc. Natl. Acad. Sci. U S A. 2003 Oct 14;100(21):12432-7. PMCID: PMC218775 (2003)
PubMed Abstract | Full Text


Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of actin-based motility.
Auerbuch V, Loureiro JJ, Gertler FB, Theriot JA, and Portnoy DA.
Mol. Microbiol. 2003 Sep;49(5):1361-75. PMID: 12940993 (2003)
PubMed Abstract | Full Text



Inducible control of virulence gene expression in Listeria monocytogenes: temporal requirement of listeriolysin O during intracellular infection.
Dancz CE, Haraga A, Portnoy DA, and Higgins DE.
J Bacteriol. 2002 Nov;184(21):5935- 45. PMCID: PMC135386 (2002)
PubMed Abstract | Full Text


Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.
O’Riordan M, Yi CH, Gonzalez R, Lee KD, and Portnoy DA.
Proc. Natl. Acad. Sci. U S A. 2002 Oct 15;99(21):13861-6. PMCID: PMC129788 (2002)
PubMed Abstract | Full Text


The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity.
Portnoy DA, Auerbuch V, Glomski IJ.
Review. J. Cell Biol. 2002 Aug 5;158(3):409-14. PMCID: PMC2173830 (2002)
PubMed Abstract | Full Text


The host cytosol: front-line or home front?
O’Riordan M and Portnoy DA.
Review. Trends Microbiol. 10:361-364. PMID: 12160633 (2002)
PubMed Abstract | Full Text


Identification of a second Listeria secA gene associated with protein secretion and the rough phenotype.
Lenz LL and Portnoy DA.
Mol. Microbiol. 2002 Aug;45(4):1043-56. PMID: 12180923 (2002)
PubMed Abstract | Full Text


Construction, characterization, and use of two Listeria monocytogenes site-specific integration vectors.
Lauer P, Chow MY, Loessner MJ, Portnoy DA, and Calendar R.
J. Bacteriol. 2002 Aug;184:4177-86. Erratum in J. Bacteriol. 2003 Feb;185(4):1484. PMCID: PMC135211 (2002)
PubMed Abstract | Full Text


The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize its activity and prevent damage to infected host cells.
Glomski IJ, Gedde MM, Tsang AW, Swanson JA, and Portnoy DA.
J. Cell Biol. 002 Mar 18;156(6):1029-38. PMCID: PMC2173464 (2002)
PubMed Abstract | Full Text


Microbial pathogenesis and the eukaryotic cytoskeleton at the American Society for Cell Biology annual meeting.
Auerbuch V and Portnoy DA.
Cell. Microbiol. 2002 Mar;4(3):187-90. PMID: 11906455 (2002)
PubMed Abstract



Systematic mutational analysis of the amino terminal domain of the Listeria monocytogenes ActA protein reveals novel functions in actin-based motility.
Lauer P, Theriot JA, Skoble J, Welch MD, and Portnoy DA.
Mol. Microbiol. 2002 Dec;42(5):1163-77. NIHMS ID: NIHMS73991 (2001)
PubMed Abstract | Full Text


Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation and Listeria monocytogenes motility.
Skoble J, Auerbuch V, Goley ED, Welch MD, and Portnoy DA.
J. Cell Biol. 2001 Oct 1;155(1):89-100. PMCID: PMC2150787 (2001)
PubMed Abstract | Full Text


Development of a competitive index assay to evaluate the virulence of Listeria monocytogenes ActA mutants during primary and secondary infection of mice.
Auerbuch V, Lenz LL, and Portnoy DA.
Infect. Immun. 2001 Sep;69(9):5953-7. PMCID: PMC98721 (2001)
PubMed Abstract | Full Text



A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity.
Decatur AL and Portnoy DA.
Science. 2000 Nov 3;290(5493):992-5. PMID: 11062133 (2000)
PubMed Abstract | Full Text


Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and L. monocytogenes motility.
Skoble J, Portnoy DA, and Welch MD.
J. Cell Biol. 2000 Aug 7;150(3):527-38. PMCID: PMC2175181 (2000)
PubMed Abstract | Full Text


“The cell biology of invasion and intracellular growth by Listeria monocytogenes.”
Cossart P and Portnoy DA.
pp. 507-15. In: Gram-Positive Pathogens. Fischetti VA, Novick RP, Ferretti JJ, Portnoy DA, and Rood JI, editors. ASM Press. Washington, DC. (2000)


Gram-Positive Pathogens. (Text)
Fischetti VA, Novick RP, Ferretti JJ, Portnoy DA, Rood JI, editors.
ASM Press. Washington, DC. (2000)


Role of listeriolysin O in the cell-to-cell spread of Listeria monocytogenes.
Gedde MM, Higgins DE, Tilney LG, and Portnoy DA.
Infect. Immun. 2000 Feb;68(2):999-1003. PMCID: PMC97240 (2000)
PubMed Abstract | Full Text



Stability of the Listeria monocytogenes ActA protein in mammalian cells is regulated by the N-end rule pathway.
Moors MA, Auerbuch V, and Portnoy DA.
Cell. Microbiol. 1999 Nov;1(3):249-57. PMID: 11207557 (1999)
PubMed Abstract | Full Text


Delivery of protein to the mammalian cell cytosol using Escherichia coli expressing listeriolysin O. Mol. Microbiol.
Higgins DE, Shastri N, Portnoy DA.
Mol. Microbiol. 1999 Mar;31(6):1631-41. PMID: 10209738 (1999)
PubMed Abstract | Full Text


Expression of listeriolysin O and ActA by intracellular and extracellular Listeria monocytogenes.
Moors MA, Levitt B, Youngman P, and Portnoy DA.
Infect. Immun. 1999 Jan;67(1):131-9. PMCID: PMC96288 (1999)
PubMed Abstract | Full Text



Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth.
Thompson RJ, Bouwer HG, Portnoy DA, Frankel FR.
Infect. Immun. 1998 Aug;66(8):3552-61. PMCID: PMC108386 (1998)
PubMed Abstract | Full Text


Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.
Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ.
Science. 1998 Jul;281(5373):105-8. PMID: 9651243 (1998)
PubMed Abstract | Full Text


Bacterial delivery of DNA evolves.
Higgins DE and Portnoy DA.
Nat. Biotechnol. 1998 Feb;16(2):138-9. PMID: 9487514 (1998)
PubMed Abstract | Full Text



“Pathogenic mechanisms of a model intracellular pathogen: how Listeria monocytogenes grows in cells.”
Portnoy DA
In: New approaches to intracellular bacterial infections. Proceedings of the 9th Kurhaus Workshop on Infectious Diseases. van der Meer JWM, Michel MF, and Verbrugh HA, editors. (1997)


How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force.
Smith GA and Portnoy DA.
Review. Trends Microbiol. 1997 July;5(7):272-6. PMID: 9234509 (1997)
PubMed Abstract | Full Text


Proteolytic pathways of activation and degradation of a bacterial phospholipase C during intracellular infection by Listeria monocytogenes.
Marquis H, Goldfine H, Portnoy DA.
J. Cell Biol. 1997 Jun 16;137(6):1381-92. PMCID: PMC2132530 (1997)
PubMed Abstract | Full Text


Influenza- specific immunity induced by recombinant Listeria monocytogenes vaccines.
Ikonomidis G, Portnoy DA, Gerhard W, Paterson Y.
Vaccine. 1997 Mar;15(4):433-40. PMID: 9141215 (1997)
PubMed Abstract | Full Text



The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin.
Smith GA, Theriot JA, Portnoy DA.
J. Cell Biol. 1996 Nov;135(3):647-60. PMCID: PMC2121076 (1996)
PubMed Abstract | Full Text


Conversion of an extracellular hemolysin into a phagosome-specific lysin which supports the growth of an intracellular pathogen.
Jones S, Preiter K, Portnoy DA.
Mol. Microbiol. 1996 Sep;21(6):1219-25. PMID: 8898390 (1996)
PubMed Abstract | Full Text


Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria monocytogenes.
Lee KD, Oh YK, Portnoy DA, and Swanson JA.
J. Biol. Chem. 1996 Mar 29;271(13):7249-52. PMID: 8631734 (1996)
PubMed Abstract | Full Text



The broad-range phospholipase C and a metalloprotease mediate listeriolysin O-independent escape of Listeria monocytogenes from a primary vacuole in human epithelial cells
Marquis H, Doshi V, Portnoy DA.
Infect. Immun. 1995 Nov;63(11):4531-4. PMCID: PMC173647 (1995)
PubMed Abstract | Full Text


The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread
Smith GA, Marquis H, Jones S, Johnston NC, Portnoy DA, and Goldfine H.
Infect. Immun. 1995 Nov;63(11):4231-7. PMCID: PMC173601 (1995)
PubMed Abstract | Full Text


Asymmetric distribution of the Listeria monocytogenes ActA protein is required and sufficient to direct actin-based motility.
Smith GA, Portnoy DA, and Theriot JA.
Mol. Microbiol. 1995 Sep;17(5):945-51. PMID: 8596443 (1995)
PubMed Abstract | Full Text


“Listeria monocytogenes: A novel vaccine vector.”
Ikonomidis G, Frankel FR, Portnoy DA, Paterson Y.
pp. 317-26. In: Vaccines 95. Cold Spring Harbor Laboratory Press. (1995)


Identification of bacterial genes that contribute to survival and growth in an intracellular environment.
Moors MA and Portnoy DA.
Review. Trends Microbiol. 1995 Mar;3(3):83-85. PMID: 7773592 (1995)
PubMed Abstract | Full Text



Characterization of Listeria monocytogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O.
Jones S and Portnoy DA.
Infect. Immun. 1994 Dec;62(12):5608-13. PMCID: PMC303309 (1994)
PubMed Abstract | Full Text


Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.
Ikonomidis G, Paterson Y, Kos FJ, Portnoy DA.
J. Exp. Med. 1994 Dec 1;180(6):2209-18. PMCID: PMC2191788 (1994)
PubMed Abstract | Full Text


“Cellular biology of Listeria monocytogenes infection.”
Portnoy DA
In: The Molecular Genetics of Bacterial Pathogenesis - A Tribute to Stanley Falkow. Miller VL, Kaper JB, Portnoy DA, and Isberg RR, editors. ASM Press, Washington, DC (1994)


Molecular Genetics of Bacterial Pathogenesis - A Tribute to Stanley Falkow.
Miller VL, Kaper JB, Portnoy DA, Isberg RR, editors.
ASM Press. Washington, DC (1994)


The cell biology of Listeria monocytogenes infection (escape from a vacuole).
Portnoy DA and Jones S.
Review. Ann NY Acad Sci 1994 Aug 15;730:15-25. Microbial Pathogenesis and Immune Response. Ades EW, Morse SA, and Rest RF, editors. PMID: 8080169 (1994)
PubMed Abstract | Full Text


Cytolysins from Intracellular Pathogens.
Andrews NW and Portnoy DA.
Review. Trends Microbiol. 1994 Aug;2(8):261-3. PMID: 7981967 (1994)
PubMed Abstract | Full Text


Dual promoters of the Listeria monocytogenes prfA transcriptional activator appear essential in vitro but are redundant in vivo.
Freitag NE and Portnoy DA.
Mol. Microbiol. 1994 Jun;12(5):845-53. PMID: 8052135 (1994)
PubMed Abstract | Full Text


Intracellular growth of bacteria.
Jones S and Portnoy DA.
Review. Methods Enzymol. 1994;236:463-7. PMID: 7968630 (1994)
PubMed Abstract | Full Text


Small plaque mutants.
Jones S and Portnoy DA.
Review. Methods Enzymol. 1994;236:526-31. PMID: 7968636 (1994)
PubMed Abstract | Full Text


Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts.
Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ.
Cell. 1994 Feb 11;76(3):505-17. PMID: 8313471 (1994)
PubMed Abstract | Full Text


Phospholipases C and the pathogenesis of Listeria.
Portnoy DA, Smith GA, Goldfine H.
Review. Braz. J. Med. Biol. Res. 1994 Feb;27(2):357-61. PMID: 8081249 (1994)
PubMed Abstract



Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.
Brundage R A, Smith GA, Camilli A, Theriot JA, Portnoy DA.
Proc. Natl. Acad. Sci. U S A. 1993 Dec 15;90(24):11890-4. PMCID: PMC48090 (1993)
PubMed Abstract | Full Text


Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants.
Marquis H, Bouwer HG, Hinrichs DJ, Portnoy DA.
Infect. Immun. 1993 Sep;61(9):3756-60. PMCID: PMC281074 (1993)
PubMed Abstract | Full Text


Regulation of the Listeria monocytogenes transcriptional activator prfA: Multiple promoter elements contribute to intracellular growth and cell-to-cell spread.
Freitag NE, Rong L, Portnoy DA.
Infect. Immun. 1993 Jun;61(6):2537-44. PMCID: PMC280881 (1993)
PubMed Abstract | Full Text


Dual roles of plcA in Listeria monocytogenes pathogenesis.
Camilli A, Tilney LG, Portnoy DA
Molec. Microbiol. 1993 Apr;8(1):143-57. PMID: 8388529 (1993)
PubMed Abstract | Full Text



"Regulation of the entry into host cytoplasm and cell-to-cell spread of Listeria monocytogenes.”
Portnoy DA and Freitag NE.
In: Molecular recognition in host-parasite interactions. Korhonen TK, Hovi T, and Makela PH, editors. Plenum Publishing Company (1992)


“Pathogenesis of Listeria monocytogenes.”
Portnoy DA
In: Mononuclear phagocytes: biology of monocytes and macrophages. van Furth R, editor. Kluwer Academic Publishers. (1992)


The interaction of bacteria with mammalian cells.
Falkow S, Isberg RR, Portnoy DA.
Review. Ann. Rev. Cell Biol. 1992;8:333-63. Review. PMID: 1476803 (1992)
PubMed Abstract | Full Text


Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.
Schafer R, Portnoy DA, Brassell SA, Paterson Y.
J. Immunol. 1992 Jul 1;149(1):53-9. PMID: 1607662 (1992)
PubMed Abstract | Full Text


Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells
Portnoy DA, Tweten RK, Kehoe M, Bielecki J.
Infect. Immun. 1992 Jul;60(7):2710-7. PMCID: PMC257225 (1992)
PubMed Abstract | Full Text


Cell biology. Devious devices of Salmonella.
Portnoy DA and Smith GA.
Nature. 1992 Jun 18;357(6379):536-7. News and Views. PMID: 1376857 (1992)
PubMed Abstract | Full Text


Listeriolysin O is a target of the immune response to Listeria monocytogenes.
Bouwer HG, Nelson CS, Gibbins BL, Portnoy DA, Hinrichs DJ.
J. Exp. Med. 1992 Jun 1;175(6):1467-71. PMCID: PMC2119232 (1992)
PubMed Abstract | Full Text


The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization.
Theriot JA, Mitchison TJ, Tilney LG, Portnoy DA.
Nature. 1992 May 21;357(6375):257-60. PMID: 1589024 (1992)
PubMed Abstract | Full Text


“Escape from the phagosome and cell-to-cell spread of Listeria monocytogenes.”
Portnoy DA, Sun AN, Bielecki J.
In: Microbial Adhesion and Invasion. Hook M and Switalski L, editors. Springer-Verlag Publishers. (1992)


Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread.
Barry RA, Bouwer HG, Portnoy DA, Hinrichs DJ.
Infect. Immun. 1992 Apr;60(4):1625-32. PMCID: PMC257039 (1992)
PubMed Abstract | Full Text


Molecular determinants of Listeria monocytogenes pathogenesis.
Portnoy DA, Chakraborty T, Goebel W, Cossart P.
Review. Infect. Immun. 1992 Apr;60(4):1263-7. PMCID: PMC256991 (1992)
PubMed Abstract | Full Text


Trancriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis.
Freitag NE, Youngman P, and Portnoy DA.
J. Bacteriol. 1992 Feb;174(4): 1293-1298. PMCID: PMC206424 (1992)
PubMed Abstract | Full Text


Innate immunity to a facultative intacellular bacterial pathogen.
Portnoy DA
Review. Curr Opin Immunol. 1992 Feb;4(1):20-4. PMID: 1596365 (1992)
PubMed Abstract | Full Text



Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent.
Camilli A, Goldfine H, Portnoy DA.
J. Exp. Med. 1991 Mar 1;173(3):751-4. PMCID: PMC2118838 (1991)
PubMed Abstract | Full Text



Actin filament nucleation by the bacterial intracellular pathogen, Listeria monocytogenes.
Tilney LG, Connelly PS, Portnoy DA.
J. Cell Biol. 1990 Dec;111(6 Pt 2):2979-88. PMCID: PMC2116415 (1990)
PubMed Abstract | Full Text


Presentation of Listeria by CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.
Brunt, LM, Portnoy DA, Unanue ER.
J. Immunol. 1990 Dec 1;145(11):3540-6. PMID: 2147195 (1990)
PubMed Abstract | Full Text


Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread.
Sun AN, Camilli A, Portnoy DA.
Infect. Immun. 1990 Nov;58(11):3770-8. PMCID: PMC313727 (1990)
PubMed Abstract | Full Text


Listeria monocytogenes moves rapidly through the host cell cytoplasm by inducing directional actin assembly.
Dabiri GA, Sanger JM, Portnoy DA, Southwick FS.
Proc. Natl. Acad. Sci. U S A. 1990 Aug; 87(16):6068-72. PMCID: PMC54473 (1990)
PubMed Abstract | Full Text


Insertional mutagenesis of Listeria monocytogenes with a novel Tn917-derivative that allows direct cloning of DNA flanking transposon insertions.
Camilli A, Portnoy DA, Youngman P.
J. Bacteriol. 1990 Jul;172(7):3738-44. PMCID: PMC213352 (1990)
PubMed Abstract | Full Text


Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells.
Bielecki J, Youngman P, Connelly P, and Portnoy DA.
Nature. 1990 May 10; 345(6271):175-176. PMID: 2110628 (1990)
PubMed Abstract | Full Text



Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm.
Portnoy DA, Schreiber RD, Connelly P, Tilney LG.
J. Exp. Med. 1989 Dec 1;170(6):2141-6. PMCID: PMC2189551 (1989)
PubMed Abstract | Full Text


Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
Tilney LG and Portnoy DA.
J. Cell Biol. 1989 Oct;109(4):1597-608. PMCID: PMC2115783 (1989)
PubMed Abstract | Full Text


Intracellular methicillin selection of Listeria monocytogenes mutants unable to replicate in a macrophage cell line.
Camilli A, Paynton CR, Portnoy DA.
Proc. Natl. Acad. Sci. U S A. 1989 Jul;86(14):5522-6. PMCID: PMC297655 (1989)
PubMed Abstract | Full Text



Role of hemolysin for the intracellular growth of Listeria monocytogenes.
Portnoy DA, Jacks PS, Hinrichs DJ.
J. Exp. Med. 1988 Apr 1;167(4):1459-71. PMCID: 2188911 (1988)
PubMed Abstract | Full Text



Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors.
Ravetch JV, Luster AD, Weinshank R, Kochan J, Pavlovec A, Portnoy DA, Hulmes J, Pan YC, Unkeless JC.
Science. 1986 Nov 7;234(4777):718-25. PMID: 2946078 (1986)
PubMed Abstract | Full Text


Cloning and characterization of a mouse cysteine proteinase.
Portnoy DA, Erickson AH, Kochan J, Ravetch JC, Unkeless JC.
J. Biol. Chem. 1986 Nov 5;261(31):14697-703. PMID: 3533924 (1986)
PubMed Abstract | Full Text



“Expression of foreign proteins on the surface of Xenopus laevis oocytes.”
Unkeless JC, Portnoy DA, Luster AD, Pure E.
pp. 427-38. In: Hybridoma Technology in the Biosciences and Medicine. Springer Publishers. (1985)


Expression of the temperature-inducible outer membrane proteins of Yersinia.
Bölin I, Portnoy DA, Wolf-Watz H.
Infect. Immun. 1985 Apr;48(1):234-40. PMCID: PMC261940 (1985)
PubMed Abstract | Full Text


Transfer of the virulence plasmid of Yersinia pestis to ersinia pseudotuberculosis.
Wolf-Watz H, Portnoy DA, Bölin I, Falkow S.
Infect. Immun. 1985 Apr;48(1):241-3. PMCID: PMC261941 (1985)
PubMed Abstract | Full Text


Role of a plasmid in the pathogenicity of Yersinia species.
Portnoy DA and Martinez RJ.
Review. Curr Top Microbiol Immunol. 1985;118:29-51. PMID: 3902382 (1985)
PubMed Abstract



Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins.
Portnoy DA, Wolf-Watz H, Bölin I, Beeder AB, Falkow S.
Infect. Immun. 1984 Jan;43(1):108-14. PMCID: PMC263395 (1984)
PubMed Abstract | Full Text



Genetic analysis of essential plasmid-mediated determinants of pathogenicity in Yersinia pestis.
Portnoy DA, Blank HF, Kingsbury DT, Falkow S.
J. Infect. Dis. 1983 Aug;148(2):297-304. PMID: 6310003 (1983)
PubMed Abstract


Bacterial plasmids -- an overview.
Falkow S and Portnoy DA
Review. Clin. Invest. Med. 1983;6(3):207-12. PMID: 6360456 (1983)
PubMed Abstract



Virulence-associated plasmids from Yersinia enterocolitica and Yersinia pestis.
Portnoy DA and Falkow S.
J. Bacteriol. 1981 Dec 1148(3):877-83. PMCID: PMC216287 (1981)
PubMed Abstract | Full Text


R-factor cointegrate formation in Salmonella typhimurium bacteriophage type 201 strains.
Helmuth R, Stephen R, Bulling E, van Leeuwen WJ, van Embden JD, Guinee PA, Portnoy D, and Falkow S.
J. Bacteriol. 1981 May;146(2): 444-52. PMCID: PMC216985 (1981)
PubMed Abstract | Full Text


Characterization of plasmid- associated determinants of Yersinia enterocolitica pathogenesis.
Portnoy DA, Moseley SL, Falkow S.
Infect. Immun. 1981 Feb;31(2):775-782. PMCID: PMC351377 (1981)
PubMed Abstract | Full Text