Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis. Rivera-Lugo R, Deng D, Anaya-Sanchez A, Tejedor-Sanz S, Tang E, Reyes Ruiz VM, Smith HB, Titov DV, Sauer JD, Skaar EP, Ajo-Franklin CM, Portnoy DA, Light SH. Elife. 2022 Apr 5;11:e75424.
RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth. Rivera-Lugo R, Light, SH, Garelis NE, Portnoy DA. Proc Natl Acad Sci USA 2022 Mar 29;119(13).
Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes. Anaya-Sanchez A, Feng Y, Berude JC, Portnoy DA.
Secretion of c-di-AMP by Listeria monocytogenes leads to a STING-dependent antibacterial response during enterocolitis. Louie A, Bhandula V, Portnoy DA. Infect Immun. 2020 Oct 5;IAI.00407-20. doi: 10.1128/IAI.00407-20. PMID: 33020211. (2020).
(p)ppGpp and ci-di-AMP homeostasis is controlled by CbpB in Listeria monocytogenes. Peterson BN, Young MKM, Luo, S, Wang J, Whiteley AT, Woodward JJ, Tong L, Wang JD, Portnoy DA. mBio 2020 Aug 25;11(4):e01625-20. doi: 10.1128/mBio.01625-20. PMID: 32843560. (2020).
Secondary structure of the mRNA encoding listeriolysin O is essential to establish the replicative niche of L. monocytogenes. Peterson BN, Portman JL, Feng Y, Wang J, Portnoy DA. Proc Natl Acad Sci - U S A. (2020).
TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes. Nguyen BN, Chavez-Arroyo A, Louie A, Cheng MI, Krasilnikov M, Portnoy DA. PLoS Pathog. 2020 Jul 7;16(7):e1008622. doi: 10.1371/journal.ppat.1008622. eCollection 2020 Jul. PMCID: PMC7340287. (2020).