Patrik Engström
Postdoctoral Fellow
PubMed | Google Scholar

Research Interests

Many pathogenic bacteria replicate in the host cell cytosol. I am interested in understanding how the surfaces of these bacteria block intracellular immune pathways. Towards elucidating these understudied mechanisms I focus on the obligate intracellular pathogen Rickettsia parkeri, which have evolved to strictly replicate in the host cell cytosol. In the Welch lab I have discovered that R. parkeri employ an outer membrane protein to protect other surface proteins from autophagy recognition, revealing a distinctive bacterial mechanism to evade antimicrobial autophagy.