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Scientific Papers (selected):
Robey, E. A., and H. K. Schachman, 1984. Site-specific mutagenesis of aspartate transcarbamoylase;
replacement of tyrosine 165 in the catalytic chain by serine reduces enzymatic activity. J. Biol. Chem. 259:
11180.
Robey, E. A., and H. K. Schachman, 1985. Regeneration of active enzyme by formation of hybrids from
inactive derivatives: implications for active sites shared between polypeptide chains of aspartate
transcarbamolyase. Proc. Natl. Acad. Sci. 82: 361.
Robey, E. A., S. R. Wente, D. W. Markby, A. Flint, Y. R. Yang, and H. K. Schachman, 1986. Effect of amino
acid substitutions on the catalytic and regulatory properties of aspartate transcarbamolyase. Proc. Natl.
Acad. Sci. 83: 5934.
Robey, E., F. Ramsdell, J. Elliott, D. Raulet, D. Kioussis, R. Axel, and B. J. Fowlkes, 1991. Expression of CD4
in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex. Proc.
Natl. Acad. Sci. 88: 608.
Robey, E. A., B. J. Fowlkes, J. W. Gordon, D. Kioussis, H. von Boehmer, F. Ramsdell, and R. Axel, 1991.
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8
lineage. Cell 64: 99.
Robey, E. A., F. Ramsdell, D. Kioussis, W. Sha, D. Loh, R. Axel, and B. J. Fowlkes, 1992. The level of CD8
expression can determine the outcome of thymic selection. Cell 69: 1089.
Itano, A , D. Kioussis, and E. A. Robey, 1994. Stochastic component to the development of class I MHC
specific T cells. Proc. Natl. Acad. Sci. 91: 220.
Robey, E., A. Itano, W. C. Fanslow and B. J. Fowlkes. 1994. Constitutive CD8 expression allows inefficient
maturation of CD4+ helper T cells in class II MHC mutant mice. Journal of Experimental Medicine. 179:1997.
Itano, A , D. Cado, F.M. Chan, and E. A. Robey, 1994. A role for the cytoplasmic tail of the chain of CD8 in
thymic selection. Immunity. 1:287.
Itano, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella and E. Robey. 1996. The cytoplasmic domain of
CD4 promotes the development of CD4 lineage T cells. Journal of Experimental Medicine 183 : 731.
Robey, E, David Chang, Andrea Itano, Dragana Cado, Heather Alexander, Deborah Lans, Gerry Weinmaster
and Patrick Salmon. 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell
lineages. Cell. 87(3):483-492
Washburn T, Schweighoffer E, Gridley T, Chang D, Fowlkes B, Cado D, Salmon P, Robey E: 1997. Notch
activity influences the alpha/beta versus gamma/delta T cell lineage decision. Cell. 88(6):833-843.
Irie, H.Y., M. Mong, A. Itano, M. Crooks, D. Littman, S.J. Burakoff, and E. Robey. 1998. The cytoplasmic domain of CD8 alpha regulates Lck kinase activation CD8 T cell development. Journal of Immunology. 161:1, 183-191
Salmon, P., Mong, M., Kang, X. J., Cado, D. and Robey, E. (1999). The role of CD8 alpha' in the CD4 versus
CD8 lineage choice. J Immunol. 163, 5312-8.
Valdez, P. and Robey, E. (2000). Notch and the CD4 versus CD8 lineage decision. CSHSQB. 64
Itano, A. and Robey, E. (2000). Highly efficient selection of CD4 and CD8 lineage thymocytes supports an
instructive model of lineage commitment. Immunity. 12: 383-389.
Chang, D., Valdez, P., Ho, T. and Robey, E. (2000). MHC recognition in thymic development: distinct, parallel
pathways for survival and lineage commitment. Journal of Immunology 165: 6710-6715.
Robey, E. and Fowlkes, BJ (2002) A reassessment of the effect of activated Notch on CD4 and CD8 T cell
development, J Immunol. Aug 15;169(4):1817-21
Bousso, P, Bhakta, N., Lewis, R. and Robey, E (2002) Dynamics of thymocyte-stromal cell interactions
visualized by 2-photon microscopy. Science, 2002 Jun 7;296(5574):1876-80
Bousso, P and Robey, E (2003) Dynamics of CD8 T Cell Priming by Dendritic Cells in Intact Lymph Nodes.
Nat Imm., Jun 4:(6) : 579-85
Huang, Y, Li, D., Winoto, A and Robey, E (2004) Distinct transcriptional programs in thymocytes responding
to T cell receptor, Notch, and positive selection signals.. Proc Nstl Acad Sci, USA, 101(14):4936-41.
Delaire S, Huang Y, Chan Shaio Wei, and Robey, E (2004) Dynamic repositioning of CD4 and CD8 genes
during T cell development. Journal of Experimental Medicine, 200, 1427-1435
Yang, L. T., Nichols, J. T., Yao, C., Manilay, J. O., Robey, E. A., and Weinmaster, G. (2004). Fringe Glycosyl-
ltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1. Mol Biol cell.
Anderson, A. C., Kitchens, E. A., Chan, S. W., St Hill, C., Jan, Y. N., Zhong, W., and Robey, E. A. (2005). The
Notch Regulator Numb Links the Notch and TCR Signaling Pathways. J Immunol 174, 890-897.
Gubbels, M. J., Striepen, B., Shastri, N.,Turkoz, M., and Robey, E. A. (2005). Class I MHC presentation of an-
tigens that escape from the parasitophorous vacuole of Toxoplasma gondii. Infect ImmunFeb;73(2):703-11
Witt, C. M., Raychaudhuri, S., Schaefer, B. C., Chakraborty, A. K., and Robey, E. A. (2005). Directed
migration of positively selected thymocytes visualized in real time. PLoS BiologyJun;3(6):e160.
Manilay, J.O,. Anderson, A.C., Kang C, and Robey, E. A. (2005). Impairment of Thymocyte Development by
Dominant-Negative Kuzbanian (ADAM-10) is Rescued by The Notch Ligand, Delta-1. J. Immunol Jun 1;174(11):6732-41.
Yin, X, and Robey, E. A. (2007) CCR7 Expression in Developing Thymocytes Is Linked to the CD4 versus CD8 Lineage Decision. J. Immunol Dec 1;179(11):7358-64.
Chtanova, T., Schaeffer, M., Han, S.-J., van Dooren, G., Nollmann, M., Herzmark, P., Chan, S.-W. Striepen, B., and Robey, E. A, et al. (2008). Dynamics of neutrophil migration in lymph nodes during infection. ImmunitySep;29(3):487-96. Epub 2008 Aug 21
E Ladi, T Schwickert, T Chtanova, Y Chen, P Herzmark, X Yin, H Aaron, S W Chan, M Lipp, B Roysam and E. A. Robey (2008) Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex, Journal of Immunology, Nov 15;181(10):7014-23
Blanchard, N., Gonzalez, F., Schaeffer, M., Joncker, N.T., Cheng, T., Shastri, A.J., Robey, E.A., and Shastri, N. (2008). Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum. Nat Immunol 9, 937-944
Chen, Y., Ladi, E., Herzmark, P., Robey, E., and Roysam, B. (2008). Automated 5-D analysis of cell migration and interaction in the thymic cortex from time-lapse sequences of 3-D multi-channel multi-photon images. J Immunol Methods. PMID: 18992251
Schaeffer, M., Han, S.J., Chtanova, T., van Dooren, G.G., Herzmark, P., Chen, Y., Roysam, B., Striepen, B., and Robey, E.A. (2009). Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol 182, 6379-6393. PMID: 19414791
LeBorgne, M., Ladi, E., Dzhagalov, I., Herzmark, P., Liao, Y., Chakraborty, A.K., and Robey, E.A. (2009). The impact of negative selection on thymocyte migration in the medulla. Nature ImmunologyAug;10(8):823-30. Epub 2009 Jun 21 PMID: 19543275
Chtanova, T., Han, S.J., Schaeffer, M., van Dooren, G.G., Herzmark, P., Striepen, B., and Robey, E.A. (2009). Dynamics of T cell, antigen presenting cell, and pathogen interactions during recall responses in the lymph node. ImmunityAug 21;31(2):342-55. . PMID: 19699173
Phee, H., Mollenauer, M., Dzhagalov, I, Robey, EA, and Weiss, A. (2010). GIT2 represses thymocyte chemotaxis and regulates positive selection in the thymus. Nat Immunology, Jun;11(6):503-11
Azar GA, Lemaître F, Robey EA, Bousso P. (2010). Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc Natl Acad Sci U S A. Feb 23;107(8):3675-80
Melichar, H., Li, O., Ross, J., Haber, H., Cado, D., Nolla, H., Robey, E.A, and Winoto, A. (2010). Comparative study of hematopoietic differentiation between human embryonic stem cell lines. Nat Immunol.
Osborn SL, Diehl G, Han SJ, Xue L, Kurd N, Hsieh K, Cado D, Robey EA, Winoto A. (2010). Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A. Jul 20;107(29):13034-9.
Melichar HJ, Li O, Herzmark P, Padmanabhan RK, Oliaro J, Ludford-Menting MJ, Bousso P, Russell SM, Roysam B, Robey EA. (2011). Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues. Immunol Cell Biol. 2010 Oct 19. [Epub ahead of print] May 89(4): 549-57
Melichar H, Li O, Ross J, Haber H, Cado D, Nolla H, Robey EA, Winoto A. (2011) Comparative Study of Hematopoietic Differentiation between Human Embryonic Stem Cell Lines. PLoS One. 6(5):e19854. Epub 2011 May 16.
Reviews (selected):
Anderson, A. C., Robey, E. A., and Huang, Y. H. Notch signaling in lymphocyte development. Curr Opin
Genet Dev. 2001 Oct;11(5):554-60.
Robey, EA, and Bluestone JA. (2004) Notch signaling in lymphocyte development and function.
Curr Opin Immunol. Jun;16(3):360-6
Bousso, P and Robey, E (2004) Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed
by 2-photon microscopy. Immunity, Sept; 21, p 349-355.
Robey, E.A (2005) Immunology: guide for a cell-fate decision. Nature. Feb 24;433(7028):813-4
Ladi, E., Yin, X., Chtanova, T., and Robey, E. A. (2006). Thymic microenvironments for T cell differentiation and selection. Nat Immunol 7, 338-343.
Robey, E. (2005). The alphabeta versus gammadelta T cell fate decision: when less is more. Immunity 22, 533-534.
Yin, X., Chtanova, T., Ladi, E., and Robey, E. A. (2006). Thymocyte motility: mutants, movies and migration patterns. Curr Opin Immunol 18, 191-197.
Coombes JL, Robey EA. (2010). Dynamic imaging of host-pathogen interactions in vivo. Nat Rev Immunol. 10(5):353-64
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