Normal aging of the prostate:

• After age 40:

  • Outer regions:

    • Atrophy of smooth muscle and proliferation of connective tissue
    • Flattening of secretory epithelium
  • Inner region:

    • Hyperplasia

• After age 60:

  • Slower, but more uniform atrophy of entire prostate
  • Accumulation of prostatic concretions
    
    Physiological Basis of Aging and Geriatrics, 2nd ed., 1998. Timiras.

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