The ability of neurons to dynamically alter their activity in response to changes in the internal or external environment is fundamental to our brain's capacity to learn and adapt. Importantly, this remarkable plasticity must be balanced by mechanisms that ensure stable activity at the level of neural circuits. Understanding the molecular machinery that allows neurons to both be dynamic and maintain balance is a fundamental goal of our research. Perturbations in synapse and circuit balance are associated with numerous neurological and psychiatric disorders, including epilepsy and autism spectrum disorder. A main focus of our laboratory is to understand how molecular changes associated with these diseases lead to altered neural activity. To address this, we are taking a multi-systems approach incorporating molecular, biochemical, electrophysiological, and behavioral analyses in mouse models and patient-derived human cells.
The Bateup Lab
Synapse and circuit function in the normal and diseased brain
Human cellular models of neurodevelopmental disorders