Gina Borgo
Graduate Student Researcher
PubMed | Google Scholar

Research Interests

Spotted fever group (SFG) Rickettsia are obligate intracellular baterial pathogens that are transmitted to vertebrate hosts through the bite of an infected tick. Although Rickettsia must access the host cytosol in order to carry out their replicative life cycle, we still lack a mechanistic understanding of how they escape the primary phagosome to enter the cytosol. I am interested in understanding how Rickettsia factors interact with host membranes to facilitate escape from the vacuole during infection. By elucidating how Rickettsia efficiently gains access to the cytosol in both human and tick hosts, I hope to answer basic questions about how bacterial proteins contribute to membrane rupture and develop experimental tools to interrogate mechanisms of pathogen escape from membrane bound compartments.