Gina Borgo
Graduate Student Researcher
PubMed | Google Scholar

Research Interests

Spotted fever group Rickettsia are obligate intracellular bacterial pathogens that are transmitted to vertebrate hosts by the bite of infected ticks. Although Rickettsia must access the host cytosol to carry out their replicative life cycle, we lack a mechanistic understanding of how Rickettsia enters the cytosol. I am interested in understanding how Rickettsia factors interact with host membranes during infection. By elucidating how Rickettsia gains access to the cytosol in both human and tick hosts, I hope to answer questions about how pathogens escape membrane bound compartments and how bacterial proteins contribute to membrane rupture.