Gary Firestone
Professor of Cell & Developmental Biology

Contact Info:
591 LSA
Berkeley, CA 94720
Firestone Lab:  Selected Publications from the last 6 years

1.  Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF, Firestone GL.   Indole-3-Carbinol Triggers AhR-dependent ER{alpha} Protein Degradation in Breast Cancer Cells Disrupting an ER{alpha}-GATA3 Transcriptional Cross-regulatory Loop. Mol Biol Cell. 2010 Feb 3. [Epub ahead of print]

2.  Firestone GL, Sundar SN.  Anticancer activities of artemisinin and its bioactive derivatives. Expert Rev Mol Med. 2009 Oct 30;11:e32. Review.

3.  Firestone GL, Sundar SN.  Minireview: modulation of hormone receptor signaling by dietary anticancer indoles. Mol Endocrinol. 2009 Dec;23(12):1940-7. Epub 2009 Oct 16.

4. Brew CT, Aronchik I, Kosco K, McCammon J, Bjeldanes LF, Firestone GL.  Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity. Int J Cancer. 2008 Dec 15. May 15;124(10):2294-302.

5.  Nguyen HH, Aronchik I, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL.  The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19750-5.

6.  Willoughby JA Sr, Sundar SN, Cheung M, Tin AS, Modiano J, Firestone GL.  Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression. J  Biol Chem. 2009 Jan 23;284(4):2203-13.

7.  Sundar SN, Marconett CN, Doan VB, Willoughby JA Sr, Firestone GL.  Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells. Carcinogenesis. 2008 Dec;29(12):2252-8.

8.  Cen H, Mao F, Aronchik I, Fuentes RJ, Firestone GL.  DEVD-NucView488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells. FASEB J. 2008 Jul;22(7):2243-52.

9.  Jump SM, Kung J, Staub R, Kinseth MA, Cram EJ, Yudina LN, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.  N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells. Biochem Pharmacol. 2008 Feb 1;75(3):713-24.

10. Buse P, Maiyar AC, Failor KL, Tran S, Leong ML, Firestone GL.  The stimulus-dependent co-localization of serum- and glucocorticoid-regulated protein kinase (Sgk) and Erk/MAPK in mammary tumor cells involves the mutual interaction with the importin-alpha nuclear import protein. Exp Cell Res. 2007 Sep 10;313(15):3261-75.

11.  Failor KL, Desyatnikov Y, Finger LA, Firestone GL.  Glucocorticoid-induced degradation of glycogen synthase kinase-3 protein is triggered by serum- and glucocorticoid-induced protein kinase and Akt signaling and controls beta-catenin dynamics and tight junction formation in mammary epithelial tumor cells. Mol Endocrinol. 2007 Oct;21(10):2403-15.

12.  Rubenstein NM, Callahan JA, Lo DH, Firestone GL.  Selective glucocorticoid control of Rho kinase isoforms regulate cell-cell interactions. Biochem Biophys Res Commun. 2007 Mar 9;354(2):603-7.

13.  Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF, Firestone GL.  Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein. Biochem Pharmacol. 2006 Dec 15;72(12):1714-23.

14.  Sundar SN, Kerekatte V, Equinozio CN, Doan VB, Bjeldanes LF, Firestone GL.  Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells. Mol Endocrinol. 2006 Dec;20(12):3070-82.

15.  Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, Bjeldanes LF, Firestone GL.  Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells. Int J Cancer. 2006 Feb 15;118(4):857-68.

16.  Hsu JC, Zhang J, Dev A, Wing A, Bjeldanes LF, Firestone GL.  Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. Carcinogenesis. 2005 Nov;26(11):1896-904.

17. Rubenstein NM, Chan JF, Kim JY, Hansen SH, Firestone GL.  Rnd3/RhoE induces tight junction formation in mammary epithelial tumor cells. Exp Cell Res. 2005 Apr 15;305(1):74-82.

18.  Garcia HH, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL.  Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex. J Biol Chem. 2005 Mar 11;280(10):8756-64.

19.  Zhang J, Hsu B A JC, Kinseth B A MA, Bjeldanes LF, Firestone GL.  Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. Cancer. 2003 Dec 1;98(11):2511-20.

20.  Guan Y, Rubenstein NM, Failor KL, Woo PL, Firestone GL.  Glucocorticoids control beta-catenin protein expression and localization through distinct pathways that can be uncoupled by disruption of signaling events required for tight junction formation in rat mammary epithelial tumor cells. Mol Endocrinol. 2004 Jan;18(1):214-27.

21.  Firestone GL, Bjeldanes LF.  Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. J Nutr. 2003 Jul;133(7 Suppl):2448S-2455S. Review.

22.  Firestone GL, Giampaolo JR, O'Keeffe BA.  Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity.  Cell Physiol Biochem. 2003;13(1):1-12. Review.

23.  Maiyar AC, Leong ML, Firestone GL.  Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Mol Biol Cell. 2003 Mar;14(3):1221-39.

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