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APEX-mediated proximity labeling of proteins in cells targeted by extracellular vesicles. Song, L., Chen, J., Su, Angela, A. and Schekman, R.
Bio-protocol 2021 (in press).

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates
Liu, X-M, Ma, L. and Schekman, R.
(2021) bioRxiv doi:

Low-bias ncRNA Libraries using Ordered Two-Template Relay: Serial Template Jumping by a Modified Retroelement Reverse Transcriptase
Upton, H.L, Ferguson, L. Temoche-Diaz, M., Liu, X-M, Pimentel, Ingolia, N., Schekman, R. and Collins, K.
(2021) bioRxiv doi: In press in the PNAS.

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Wouters , R., Michiels, C., , Sannerud, R., Kleizen, B., , Dillen, K.,  Vermeire W.,  Escamilla-Ayala, A.,  Demedts, D., Schekman, R. and Annaert, W.
J. Cell. Biol. 2021 (in press)

Open science takes on Parkinson's disease.
Riley EA, Schekman R.
Elife. 2021 Feb 25;10:e66546. doi: 10.7554/eLife.66546.

Extracellular vesicles from neuronal cells promote neural induction of mESCs through cyclinD1.
Song, Lu, Tian, X. and Schekman, R.
J. Cell. Biol. 2021 Sep 6;220(9):e202101075. doi: 10.1083/jcb.202101075.

Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.

Melville DB, Studer S, Schekman R.
J Biol Chem. 2020 Jun 19;295(25):8401-8412. doi: 10.1074/jbc.RA120.012964. Epub 2020 May 1.

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer.
Bajaj L, Sharma J, di Ronza A, Zhang P, Eblimit A, Pal R, Roman D, Collette JR, Booth C, Chang KT, Sifers RN, Jung SY, Weimer JM, Chen R, Schekman RW, Sardiello M.
J Clin Invest. 2020 Jun 29:130955. doi: 10.1172/JCI130955.

Buoyant Density Fractionation of Small Extracellular Vesicle Sub-populations Derived from Mammalian Cells.

Temoche-Diaz, M. M., Shurtleff, M. J. and Schekman, R.
Bio-protocol . 2020 Aug 5; 10(15): e3706. DOI: 10.21769/BioProtoc.3706.

Progress and promise.
Schekman R.
Elife. 2019 Jan 23;8. pii: e44799. doi: 10.7554/eLife.44799.

Regulation of LC3 Lipidation by the Autophagy-Specific Class III Phosphatidylinostitol-3 Kinase Complex.

Brier LW, Ge L, Stjepanovic G, Thelen AM, Hurley J, Schekman R.
Mol Biol Cell. 2019 Feb 27:mbcE18110743. doi: 10.1091/mbc.E18-11-0743.

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes.
Temoche-Diaz MM, Shurtleff MJ, Nottingham RM, Yao J, Fadadu RP, Lambowitz AM, Schekman R.
Elife. 2019 Aug 22;8. pii: e47544. doi: 10.7554/eLife.47544.

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.
Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J.
J Cell Biol. 2019 Sep 5. pii: jcb.201902028. doi: 10.1083/jcb.201902028.

Coordinating a new approach to basic research into Parkinson's disease.
Schekman R, Riley EA.
Elife. 2019 Sep 25;8. pii: e51167. doi: 10.7554/eLife.51167.

In Memoriam: Lelio Orci, 1937–2019
Roberto MontesanoRandy SchekmanJames Rothman, and Alain Perrelet
Proc Natl Acad Sci U S A. 2019 Dec 16. doi: 10.1073/pnas.1920094117

Extracellular Vesicles and Cancer: Caveat Lector

Matthew J. Shurtleff, Morayma M. Temoche-Diaz, Randy Schekman
Annual Review of Cancer Biology 2018 2:1, 395-411

Unconventional secretion of FABP4 by endosomes and secretory lysosomes.
Villeneuve J, Bassaganyas L, Lepreux S, Chiritoiu M, Costet P, Ripoche J, Malhotra V, Schekman R.
J Cell Biol. 2018 Feb 5;217(2):649-665. doi: 10.1083/jcb.201705047. Epub 2017 Dec 6.

Transparency in authors' contributions and responsibilities to promote integrity in scientific publication.
McNutt MK, Bradford M, Drazen JM, Hanson B, Howard B, Jamieson KH, Kiermer V, Marcus E, Pope BK, Schekman R, Swaminathan S, Stang PJ, Verma IM.
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2557-2560. doi: 10.1073/pnas.1715374115. Epub 2018 Feb 27.

How early-career researchers are shaping eLife.
Patterson M, Schekman R.
Elife. 2018 Mar 27;7. pii: e36263. doi: 10.7554/eLife.36263.

A new twist on peer review.
Patterson M, Schekman R.
Elife. 2018 Jun 26;7. pii: e36545. doi: 10.7554/eLife.36545.

A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network.
Ma T, Li B, Wang R, Lau PK, Huang Y, Jiang L, Schekman R, Guo Y.
J Biol Chem. 2018 Jun 1;293(22):8410-8427. doi: 10.1074/jbc.RA118.001906. Epub 2018 Apr 17.

Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.
Melville D, Gorur A, Schekman R.
Mol Biol Cell. 2019 Feb 1;30(3):387-399. doi: 10.1091/mbc.E18-09-0548. Epub 2018 Nov 28.

TANGO1 and SEC12 are copackaged with procollagen I to facilitate the generation of large COPII carriers.
Yuan L, Kenny SJ, Hemmati J, Xu K, Schekman R.
Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12255-E12264. doi: 10.1073/pnas.1814810115. Epub 2018 Dec 13.

COPII-coated membranes function as transport carriers of intracellular procollagen I.
Gorur A, Yuan L, Kenny SJ, Baba S, Xu K, Schekman R.
J Cell Biol. 2017 Apr 20. pii: jcb.201702135. doi: 10.1083/jcb.201702135.

Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis.
Ge L, Zhang M, Kenny SJ, Liu D, Maeda M, Saito K, Mathur A, Xu K, Schekman R.
EMBO Rep. 2017 Jul 28. pii: e201744559. doi: 10.15252/embr.201744559.

Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.
Sirkis DW, Aparicio RE, Schekman R.
Mol Biol Cell. 2017 Aug 2. pii: mbc.E17-06-0423. doi: 10.1091/mbc.E17-06-0423.

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.
Hanna MG 4th, Block S, Frankel EB, Hou F, Johnson A, Yuan L, Knight G, Moresco JJ, Yates JR 3rd, Ashton R, Schekman R, Tong Y, Audhya A.
Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7707-E7716. doi: 10.1073/pnas.1709120114. Epub 2017 Aug 29.

Room at the top.
Schekman R.
Elife. 2017 Oct 12;6. pii: e31697. doi: 10.7554/eLife.31697.

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes.
Shurtleff MJ, Yao J, Qin Y, Nottingham RM, Temoche-Diaz MM, Schekman R, Lambowitz AM.
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8987-E8995. doi: 10.1073/pnas.1712108114. Epub 2017 Oct 10.

Cell-free Generation of COPII-coated Procollagen I Carriers.
Yuan L, Baba S, Bajaj K, Schekman R.
Bio Protoc. 2017 Nov 20;7(22). pii: e2450. doi: 10.21769/BioProtoc.2450.

Distinct stages in the recognition, sorting, and packaging of proTGFα into COPII-coated transport vesicles.
Zhang P, Schekman R.
Mol Biol Cell. 2016 Jun 15;27(12):1938-47. doi: 10.1091/mbc.E16-02-0090. Epub 2016 Apr 27.

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.
Shurtleff MJ, Temoche-Diaz MM, Karfilis KV, Ri S, Schekman R.
Elife. 2016 Aug 25;5. pii: e19276. doi: 10.7554/eLife.19276.

Building a sustainable future for eLife.
Patterson M, Schekman R.
Elife. 2016 Sep 29;5. pii: e21230. doi: 10.7554/eLife.21230.

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.
McGourty CA, Akopian D, Walsh C, Gorur A, Werner A, Schekman R, Bautista D, Rape M.
Cell. 2016 Oct 6;167(2):525-538.e14. doi: 10.1016/j.cell.2016.09.026.

Recognizing the importance of new tools and resources for research.
Schekman R, Weigel D, Watt FM.
Elife. 2015 Mar 31;4. doi: 10.7554/eLife.07083.

Avoidance of Autophagy Mediated by PlcA or ActA Is Required for Listeria monocytogenes Growth in Macrophages.

Mitchell G, Ge L, Huang Q, Chen C, Kianian S, Roberts MF, Schekman R, Portnoy DA.
Infect Immun. 2015 May;83(5):2175-84.

Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum.
Bajaj Pahuja K, Wang J, Blagoveshchenskaya A, Lim L, Madhusudhan MS, Mayinger P, Schekman R.
Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3199-206.

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion.
Zhang M, Kenny SJ, Ge L, Xu K, Schekman R.
Elife. 2015 Nov 2;4. pii: e11205.

Biogenesis of autophagosomal precursors for LC3 lipidation from the ER-Golgi intermediate compartment.
Ge L, Wilz L, Schekman R.
Autophagy. 2015 Nov;11(12):2372-4.

Unique COPII component AtSar1a/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana.
Zeng Y, Chung KP, Li B, Lai CM, Lam SK, Wang X, Cui Y, Gao C, Luo M, Wong KB, Schekman R, Jiang L.
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14360-5.

The ER-Golgi intermediate compartment feeds the phagophore membrane.
Ge L, Schekman R.
. 2014 Jan;10(1):170-2.

Regulated oligomerization induces uptake of a membrane protein into COPII vesicles independent of its cytosolic tail.
Springer S, Malkus P, Borchert B, Wellbrock U, Duden R, Schekman R.
. 2014 May;15(5):531-45.

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.
Higa A, Taouji S, Lhomond S, Jensen D, Fernandez-Zapico ME, Simpson JC, Pasquet JM, Schekman R, Chevet E.
Mol Cell Biol
. 2014 May;34(10):1839-49.

The protein-vesicle network of autophagy.
Ge L, Baskaran S, Schekman R, Hurley JH.
Curr Opin Cell Biol. 2014 Aug;29C:18-24.

Peroxisomes are juxtaposed to strategic sites on mitochondria.
Cohen Y, Klug YA, Dimitrov L, Erez Z, Chuartzman SG, Elinger D, Yofe I, Soliman K, Gärtner J, Thoms S, Schekman R, Elbaz-Alon Y, Zalckvar E, Schuldiner M.
Mol Biosyst. 2014 Jul;10(7):1742-8.

Advancing research.
Patterson M, Schekman R, Watt FM, Weigel D.
Elife. 2014 Aug 13;3:e03980. doi: 10.7554/eLife.03980.

Protein Sorting at the trans-Golgi Network.
Guo Y, Sirkis DW, Schekman R.
Annu Rev Cell Dev Biol. 2014 Aug 18.

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment.
Ge L, Zhang M, Schekman R.
. 2014 Nov 28;3:e04135.
Guo Y, Zanetti G, Schekman R.
A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network. Elife. 2013;2:e00160. Abstract.

Jakobsen MK, Cheng Z, Lam SK, Roth-Johnson E, Barfield RM, Schekman R.
Phosphorylation of Chs2p regulates interaction with COPII. J Cell Sci. 2013 May 15;126(Pt 10):2151-6. Abstract.

Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D.
SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Elife. 2013 Apr 9;2:e00444. Abstract.

Schekman R, Watt F, Weigel D.
The eLife approach to peer review. Elife. 2013 Apr 30;2:e00799. doi: 10.7554/eLife.00799.

Schekman R, Patterson M.
Reforming research assessment. Elife. 2013 May 16;2:e00855. doi: 10.7554/eLife.00855.

Dimitrov L, Lam SK, Schekman R.
The role of the endoplasmic reticulum in peroxisome biogenesis. Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a013243. Abstract.

Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, Barton GM.
UNC93B1 mediates differential trafficking of endosomal TLRs. Elife. 2013;2:e00291. Abstract.

Zhang M, Schekman R.
Cell biology. Unconventional secretion, unconventional solutions. Science. 2013 May 3;340(6132):559-61. Abstract.

Miller EA, Schekman R.
COPII - a flexible vesicle formation system. Curr Opin Cell Biol. 2013 Aug;25(4):420-7. Abstract.

Ge L, Melville D, Zhang M, Schekman R.
The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife. 2013 Aug 6;2:e00947. Abstract.

Schekman R.
Discovery of the cellular and molecular basis of cholesterol control. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14833-6. Abstract.

Zanetti G, Prinz S, Daum S, Meister A, Schekman R, Bacia K, Briggs JA.
The structure of the COPII transport-vesicle coat assembled on membranes. Elife. 2013 Sep 17;2:e00951. Abstract.

la Cour JM, Schindler AJ, Berchtold MW, Schekman R.
ALG-2 Attenuates COPII Budding In Vitro and Stabilizes the Sec23/Sec31A Complex. PLoS One. 2013 Sep 19;8(9):e75309. Abstract.

Schekman R, Watt FM, Weigel D.
A year in the life of eLife. Elife. 2013 Oct 15;2:e01516. doi: 10.7554/eLife.01516.

Schekman R, Watt FM, Weigel D.
eLife and early career researchers. Elife. 2013 Oct 22;2:e01633. doi: 10.7554/eLife.01633.

Jin L, Pahuja KB, Wickliffe KE, Gorur A, Baumgärtel C, Schekman R, Rape M.
Ubiquitin-dependent regulation of COPII coat size and function. Nature 482, 495-500 (2012). Abstract.

Kim SD, Pahuja KB, Ravazzola M, Yoon J, Boyadjiev SA, Hamamoto S, Schekman R, Orci L, Kim J.
SEC23-SEC31 interface plays critical role for export of procollagen from the endoplasmic reticulum. J. Biol. Chem. 287, 10134-44 (2012). Abstract.

Choy RW, Cheng Z, Schekman R.
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid beta production in the trans-Golgi network. PNAS 109, E2077-82 (2012). Abstract.

Starr TL, Pagant S, Wang CW, Schekman R.
Sorting signals that mediate traffic of chitin synthase III between the TGN/endosomes and to the plasma membrane in yeast. PLoS One. 7(10):e46386
(2012). Abstract.

Schekman R, Patterson M, Watt FM, Weigel D.
Launching eLife, Part 1. Elife. 2012 Oct 15;1:e00270. doi: 10.7554/eLife.00270.

Schekman R, Watt FM, Weigel D.
Launching eLife, Part 2. Elife. 2012 Dec 13;1:e00365. doi: 10.7554/eLife.00365.

Zanetti G, Pahuja KB, Studer S, Shim S, Schekman R.
COPII and the regulation of protein sorting in mammals. Nat Cell Biology 14, 20-28 (2011). Abstract.

Jin Y, Sultana A, Gandhi P, Franklin E, Hamamoto S, Khan AR, Munson M, Schekman R, Weisman LS.
Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Dev Cell 21, 1156-70 (2011). Abstract.

Kung LF, Pagant S, Futai E, D'Arcangelo JG, Buchanan R, Dittmar JC, Reid RJ, Rothstein R, Hamamoto S, Snapp EL, Schekman R, Miller EA.
Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat. EMBO J. 31, 1014-27 (2011). Abstract.

Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D.
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin. Blood 118, 3384-91 (2011). Abstract.

Rothman JE, Schekman R.
Molecular mechanism of protein folding in the cell. Cell 146, 851-854 (2011). Abstract.

Bacia K, Futai E, Prinz S, Meister A, Daum S, Glatte D, Briggs JA, Schekman R.
Multibudded tubules formed by COPII on artificial liposomes. Scientific Reports 1, 17 (2011). Abstract.

Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD.
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol 12, 41-6 (2010). Abstract.

Lam SK, Yoda N, Schekman R.
A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum. PNAS 107, 21523-8 (2010). Abstract.

Boyadjiev S, Kim SD, Hata A, Haldeman-Englert C, Zackai E, Naydenov C, Hamamoto S, Schekman R, Kim J.
Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion. Clinical Genetics 79, no. doi: 10.1111/j.1399-0004.2010.01550.x (2010). Abstract.

Schekman R.
Charting the secretory pathway in a simple eukaryote. Mol Biol Cell 22, 3781-4 (2010). Abstract.

Saito K, Chen M, Bard F, Chen S, Zhou H, Woodley D, Polischuk R, Schekman R, Malhotra V.
TANGO1: a unique cargo packer at Endoplasmic Reticulum exit sites. Cell 136, 891-902 (2009). Abstract.

Tran, JH, Ching-Jen C., Emr, S., and Schekman R.
Cargo sorting into multivesicular bodies in vitro. PNAS 106, 17395-400 (2009). Abstract.

Schindler, A and Schekman, R.
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. PNAS 106, 17775-80 (2009). Abstract.

Robyn M. Barfield, J. Christopher Fromme, and Randy Schekman.
The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast. Mol Biol Cell 20, 4985-96 (2009). Abstract.

Schekman, R.
Change is good: life outside the nucleus. Nature Cell Biology 11, 1274 (2009). Article.

Fromme, J. C., Orci, L. and Schekman, R.
Coordination of COPII vesicle trafficking by Sec23Trends Cell Biol. 18, 330-337 (2008). Abstract.

Wickner, William, and Schekman, Randy
Membrane fusionNature Struc. & Mol. Biol. 15, 658-664 (2008). Abstract.

Scott, Daniel C., and Schekman, Randy
Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteinsJ. Cell Biol. 181, 1095-1105 (2008). Abstract.

Schekman, R.
George E. Palade (1912-2008). Science 322, 695 (2008). Article.

Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman R.
Biogenesis of gamma-secretase early in the secretory pathway. J. Cell Biol. 179, 951-963 (2007). Abstract.

Fromme JC, Ravazzola M, Hamamoto S, Al-Balwi M, Eyaid W, Boyadjiev SA, Cosson P, Schekman R, Orci L.
The genetic basis of a craniofacial disease provides insight into COPII coat assembly. Dev. Cell 13, 623-634 (2007). Abstract.

Kim J, Thanabalasuriar A, Chaworth-Musters T, Fromme JC, Frey EA, Lario PI, Metalnikov P, Rizg K, Thomas NA, Lee SF, Hartland EL, Hardwidge PR, Pawson T, Strynadka NC, Finlay BB, Schekman R, Gruenheid S.
The Bacterial Virulence Factor NleA Inhibits Cellular Protein Secretion by Disrupting Mammalian COPII Function. Cell Host and Microbe 2, 160-171 (2007). Abstract.

Harsay, E., and Schekman, R.
Avl9p, a Member of a Novel Protein Superfamily, Functions in the Late Secretory Pathway. Mol. Biol. Cell. 18(4), 1203-19 (2007). Abstract.

Copic, A., Starr, T., and Schekman, R.
Ent3p and Ent5p Exhibit Cargo-specific Functions in Trafficking Proteins between the Trans-Golgi Network and the Endosomes in Yeast. Mol. Biol. Cell. 18(5), 1803-15 (2007). Abstract.

Schekman, R.
The nine lives of Daniel E. Koshland, Jr. (1920–2007). PNAS 104, 14551–14552 (2007). Article.

Schekman, R.
Arthur Kornberg 1918–2007. Cell 131, 637-639 (2007). Article.

Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, Hur DJ, Zhang G, Hamamoto S, Schekman R, Ravazzola M, Orci L, Eyaid W.
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal ER-to-Golgi trafficking. Nature Genetics 38(10), 1192-1197 (2006). Abstract.

Wang, C. W., Hamamoto, S., Orci, L., and Schekman, R.
Exomer: a coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J. Cell Biol. 174(7), 973-983 (2006). Abstract.

Sanchatjate, S., and Schekman, R.
Chs5/6 Complex: A Multi-Protein Complex That Interacts with and Conveys Chitin Synthase III from the Trans-Golgi Network to the Cell Surface. Mol. Biol. Cell. 17(10), 4157-4166 (2006). Abstract.

Bucci, M.
Randy Schekman. Nature Chemical Biology 2, 568 (2006). Article.

Lee, M.C.S., Orci, L., Hamamoto, S., Futai, E., Ravazzola, M., and Schekman, R.
Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Cell 122, 605-617 (2005). Abstract.

Miller, E. A., Liu, Y., Barlowe, C., and Schekman, R.
ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p. Mol. Biol. Cell. 16, 3719-3726 (2005). Abstract.

Fromme, J.C., and Schekman, R.
COPII-coated vesicles: flexible enough for large cargo? Curr. Opin. Cell Biol. 17, 345-352 (2005). Abstract.

Schekman, R.
Peroxisomes: another branch of the secretory pathway? Cell 122, 1-2 (2005). Abstract.

Futai, E., and Schekman, R.
Purification and functional properties of Sec12 GEF. Meth Enzymol. 404, 74-82 (2005). Abstract.

Wickner, William and Schekman, Randy.
Protein translocation across biological membranes. Science 310, 1452-1456 (2005). Abstract.

Schekman, R.
Membrane traffic in landmark papers in yeast biology, a chapter in Landmark Papers. Cold Spring Harbor Press (Eds. P. Linder, D. Shore and M. Hall) pgs. 243-252 (2005).

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Kim, Jinoh, Hamamoto, Susan, Ravazzola, Mariella, Orci, Lelio, and Schekman, Randy.
Uncoupled packaging of amyloid precursor protein and presenilin 1 into COPII vesicles. J. Biol. Chem. 280, 7758-7768 (2004). Abstract.

Sun, Yidi, Kaksonen, Marko, Madden, David T., Schekman, Randy, and Drubin, David G.
Interaction of Sla2p's ANTH domain with PtdIns(4,5)P2 is important for actin-dependent endocytic internalization. Mol. Biol. Cell 16, 717-730 (2004). Abstract.

Malkus, Per, Graham, L. A., Stevens, T. H., and Schekman, Randy.
Role of Vma21p in assembly and transport of the yeast vacuolar ATPase. Mol. Biol. Cell 15, 5075-5091 (2004). Abstract.

Futai, Eugene, Hamamoto, Susan, Orci, Lelio and Schekman, Randy.
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes. EMBO J. 23, 4286-4296 (2004). Abstract.

Schekman, Randy.
A channel for protein waste. Nature 429, 817-818 (2004). Article.

Schekman, Randy.
Merging cultures in the study of membrane traffic. Nature Cell Biol. 6, 483-486 (2004). Abstract.

Lee, Marcus C. S., Miller, E. A., Goldberg, J., Orci, L., and Schekman, Randy.
Bi-directional protein transport between the ER and Golgi. Annu. Rev. Cell Dev. Biol. 20, 87-123 (2004). Abstract.

Kim, Jinoh, and Schekman, Randy.
The ins and outs of presenilin 1 membrane topology. PNAS 101, 905-906 (2004). Article.

Lee, Marcus C. S., and Schekman, R.
BAR domains go on a bender. Science 303, 479-480 (2004). Article.

Schekman, Randy, and Novick, Peter.
23 genes, 23 years later. Cell S116, S13-S15 (2004). Article.

Antonny, B., Gounon, P., Schekman, R., and Orci, L.
Self-assembly of minimal COPII cages. EMBO Reports 4, 419-424 (2003). Abstract.

Valdivia, R., and Schekman, R.
The yeast Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. Proc. Natl. Acad. Sci. USA 100,10287-10292 (2003). Abstract.

Miller, E., Beilharz, T. H., Malkus, P. N., Lee, M.C.S., Hamamoto, S., Orci, L., and Schekman, R.
Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114, 1-20 (2003). Abstract.

Harsay, E., and Schekman, R.
A subset of yeast vacuolar protein sorting mutants are blocked in one branch of the exocytic pathway. J. Cell Biol. 156, 271-286 (2002). Abstract.

Valdivia, R. H., Baggott, D., Chuang, J. S., and Schekman, R. W.
The yeast clathrin adaptor protein complex-1 is required for the efficient retention of a subset of late-Golgi membrane proteins. Dev. Cell 2, 283-294 (2002). Abstract.

Marcus C.S. Lee, Susan Hamamoto, and Randy Schekman
Ceramide biosynthesis is required for the formation of oligomeric H+-ATPase, Pma1p, in the yeast endoplasmic reticulum .J. Biol. Chem., 277, 22395-22401 (2002). Abstract.

Shimoni, Y., and Schekman, R.
Vesicle budding from the ER. Meth. Enzymol. 351, 258-278 (2002).

Supek, F., Madden, D. T., Hamamoto, S., Orci, L., and Schekman, R.
Sec16p potentiates the action of COPII proteins to bud transport vesicles. J. Cell Biol. 158, 1029-1038 (2002). Abstract.

Miller, E., Antonny, B., Hamamoto, S., and Schekman, R.
Cargo selection into COPII vesicles is driven by the Sec24p subunit. EMBO J. 21, 6105-6113 (2002). Abstract.

Schekman, R.
SEC mutants and the secretory apparatus. Nature Medicine 8, 1055-1058 (2002).

Deloche, O., and Schekman, R. W.
Vps10p cycles between the TGN and the late endosome via the plasma membrane in clathrin mutants. Mol. Biol. Cell 13, 4296-4307 (2002). Abstract.

Malkus, P., Jiang, F., and Schekman, R.
Concentrative sorting of secretory cargo proteins into COPII-coated vesicles. J. Cell Biol. 159, 915-921 (2002). Abstract.

Deloche O, Yeung BG, Payne GS, Schekman R.
Vps10p Transport from the trans-Golgi Network to the Endosome Is Mediated by Clathrin-coated Vesicles. Mol Biol Cell. 12, 475-485 (2001). Abstract.

Spang, A., Herrmann, J. M., Hamamoto, S., and Schekman, R.
The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Mol. Biol. Cell 12, 1035-1045 (2001). Abstract.

Antonny, B., Madden, D., Hamamoto, S., Orci, L., and Schekman, R.
Dynamics of the COPII coat with GTP and stable analogues. Nature Cell Biol. 3, 531-537 (2001). Abstract.

Antonny, B., and Schekman, R.
ER export: Public transportation by the COPII coach. Curr. Opin. Cell Biol. 13, 438-443 (2001). Abstract.

Lederkremer, G. Z., Cheng, Y., Petre, B. V., Vogan, E., Springer, S., Schekman, R., Walz, T., and Kirchhausen, T.
Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. PNAS 98, 10704-10709 (2001). Abstract.

Matsuoka, K., Schekman, R., Orci, L., and Heuser, J.
Surface structure of the COPII-coated vesicle. PNAS 98, 13705-13709 (2001). Abstract.

Click here to see a list of older papers (1990-2000) from the Schekman lab.

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