Research Interests

Our laboratory performs research on breast cancer. We are using in vivo and in vitro experimental approaches to determine the biological and molecular bases for susceptibility and resistance to breast carcinogenesis as well as for the prevention of breast cancer. By using the rat mammary carcinogenesis model system, we are currently focusing on studies to elucidate the mechanisms involved in determining the high susceptibility and high resistance of nulliparous and parous rats, respectively, to chemical carcinogen induced breast carcinogenesis.

Selected Publications

Estrogen can prevent breast cancer by mimicking the protective effect of pregnancy. [S. Nandi, R.C. Guzman, G. Thordarson and L. Rajkumar. (2005) In Hormonal Carcinogenesis, vol 4, (J.J. Li et al., eds.), Springer-Verlag, 153-165]

Short-term exposure to pregnancy levels of estrogen prevents mammary
carcinogenesis. [L. Rajkumar, R.C. Guzman, J. Yang, G. Thordarson, F. Talamantes and S. Nandi. (2001) Proc. Nat. Acad. Sci. USA 98:11755-11759]

Hormonal prevention of breast cancer: Mimicking the protective effect of pregnancy. [R. Guzman, J. Yang, L. Rajkumar, G. Thordarson, X. Chen and S. Nandi. (1999) Proc. Nat. Acad. Sci. USA 96:2520-2525]

Hormones and mammary carcinogenesis in mice, rats, and humans: A
unifying hypothesis. [S. Nandi, R. Guzman, and J. Yang. (1995) Proc. Natl. Acad. Sci. USA 92:3650-3657]