Figure 5: Multiple cohesin
complexes tether meiotic
chromosomes. (Top), A schematic
diagram of meiotic-specific cohesin
complexes and a mitotic cohesin
complex. These cohesin complexes
share two SMC proteins and one
non-SMC protein but differ in the
non-SMC subunit called kleisin.
Klesin subunit REC-8 and the two
nearly identical kleisin paralogs
COH-3 and COH-4 are meiotic
specific. SCC-1 mediates sister
chromatid cohesion during mitosis.
(Bottom), Confocal micrographs of
paired and synapsed homologous
meiotic chromosomes (pachytene
chromosomes) show that REC-8
and COH-3/4 are present all along
the homologs and co-localize with
the axis protein HTP-3.
Figure 7: Multiple cohesin complexes
tether meiotic chromosomes. (Top), A
schematic diagram of meiotic-specific cohesin
complexes and a mitotic cohesin complex. These
cohesin complexes share two SMC proteins and
one non-SMC protein but differ in the non-SMC
subunit called kleisin. Klesin subunit REC-8 and
the two nearly identical kleisin paralogs COH-3
and COH-4 are meiotic specific. SCC-1 mediates
sister chromatid cohesion during mitosis.
(Bottom), Confocal micrographs of paired and
synapsed homologous meiotic chromosomes
(pachytene chromosomes) show that REC-8 and
COH-3/4 are present all along the homologs and
co-localize with the axis protein HTP-3.