Figure 5: Multiple cohesin complexes tether meiotic chromosomes. (Top), A schematic diagram of
meiotic-specific cohesin complexes and a mitotic cohesin complex. These cohesin complexes share two SMC
proteins and one non-SMC protein but differ in the non-SMC subunit called kleisin. Klesin subunit REC-8 and
the two nearly identical kleisin paralogs COH-3 and COH-4 are meiotic specific. SCC-1 mediates sister chromatid
cohesion during mitosis. (Bottom), Confocal micrographs of paired and synapsed homologous meiotic
chromosomes (pachytene chromosomes) show that REC-8 and COH-3/4 are present all along the homologs and
co-localize with the axis protein HTP-3.
Figure 5: Multiple cohesin complexes tether meiotic chromosomes. (Top), A schematic diagram of
meiotic-specific cohesin complexes and a mitotic cohesin complex. These cohesin complexes share two SMC
proteins and one non-SMC protein but differ in the non-SMC subunit called kleisin. Klesin subunit REC-8 and the two
nearly identical kleisin paralogs COH-3 and COH-4 are meiotic specific. SCC-1 mediates sister chromatid cohesion
during mitosis. (Bottom), Confocal micrographs of paired and synapsed homologous meiotic chromosomes
(pachytene chromosomes) show that REC-8 and COH-3/4 are present all along the homologs and co-localize with the
axis protein HTP-3.
Figure 5: Multiple cohesin complexes tether meiotic chromosomes. (Top), A
schematic diagram of meiotic-specific cohesin complexes and a mitotic cohesin
complex. These cohesin complexes share two SMC proteins and one non-SMC
protein but differ in the non-SMC subunit called kleisin. Klesin subunit REC-8 and
the two nearly identical kleisin paralogs COH-3 and COH-4 are meiotic specific.
SCC-1 mediates sister chromatid cohesion during mitosis. (Bottom), Confocal
micrographs of paired and synapsed homologous meiotic chromosomes
(pachytene chromosomes) show that REC-8 and COH-3/4 are present all along the
homologs and co-localize with the axis protein HTP-3.
Figure 5: Multiple cohesin complexes tether meiotic chromosomes. (Top), A schematic diagram of meiotic-specific
cohesin complexes and a mitotic cohesin complex. These cohesin complexes share two SMC proteins and one
non-SMC protein but differ in the non-SMC subunit called kleisin. Klesin subunit REC-8 and the two nearly identical
kleisin paralogs COH-3 and COH-4 are meiotic specific. SCC-1 mediates sister chromatid cohesion during mitosis.
(Bottom), Confocal micrographs of paired and synapsed homologous meiotic chromosomes (pachytene
chromosomes) show that REC-8 and COH-3/4 are present all along the homologs and co-localize with the axis protein
HTP-3.
Figure 5: Multiple cohesin complexes tether meiotic chromosomes. (Top), A schematic diagram of
meiotic-specific cohesin complexes and a mitotic cohesin complex. These cohesin complexes share two SMC
proteins and one non-SMC protein but differ in the non-SMC subunit called kleisin. Klesin subunit REC-8 and the two
nearly identical kleisin paralogs COH-3 and COH-4 are meiotic specific. SCC-1 mediates sister chromatid cohesion
during mitosis. (Bottom), Confocal micrographs of paired and synapsed homologous meiotic chromosomes
(pachytene chromosomes) show that REC-8 and COH-3/4 are present all along the homologs and co-localize with the
axis protein HTP-3.
Figure 7: Multiple cohesin complexes tether meiotic chromosomes. (Top), A schematic diagram of
meiotic-specific cohesin complexes and a mitotic cohesin complex. These cohesin complexes share two SMC
proteins and one non-SMC protein but differ in the non-SMC subunit called kleisin. Klesin subunit REC-8 and the two
nearly identical kleisin paralogs COH-3 and COH-4 are meiotic specific. SCC-1 mediates sister chromatid cohesion
during mitosis. (Bottom), Confocal micrographs of paired and synapsed homologous meiotic chromosomes
(pachytene chromosomes) show that REC-8 and COH-3/4 are present all along the homologs and co-localize with the
axis protein HTP-3.
