Post-doctoral Fellow
Research
During my studies of biology at the University of Cologne in Germany I began to develop interest in metabolic signaling pathways and the underlying mechanisms of human metabolic diseases. I therefore decided to join Professor Jens Bruening’s research group at the Institute for Genetics in Cologne to study mouse models of obesity and type 2 diabetes. As a Ph.D. student in the Bruening lab I studied the contribution of dysregulated hepatic miRNA expression to the development of insulin resistance and type 2 diabetes. Using a novel mouse model that I have generated, I identified obesity- induced over-expression of miRNA-143 as a crucial regulator of hepatic insulin action and whole-body glucose homeostasis.
For my postdoctoral research training I joined Professor Katja Lamia’s laboratory at the Scripps Research Institute in La Jolla, CA to study the regulation of cellular and organismal metabolism by circadian clocks. In particular, I am interested in the crosstalk between the circadian core clock and metabolic signaling pathways in skeletal muscle. In the Dillin lab I am now focusing my studies on the role of circadian core clock components in mitochondrial biogenesis and function.
Awards
German Research Foundation (DFG) Fellow 12/2011 - 02/2014
American Heart Association Fellow 01/2015 - 12/2016
Publications
Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco JJ, Yates JR, Lamia KA. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Elife. 2015 Mar 10;4. doi: 10.7554/eLife.04883.
Hess ME*, Hess S*, Meyer KD, Verhagen LAW, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC. The Fat Mass and Obesity-Associated (Fto) Gene Regulates Activity of the Dopaminergic Midbrain Circuitry. Nat Neurosci. 2013 Jun 30. doi: 10.1038/nn.3449. *These authors contributed equally
Jordan SD, Lamia KA. AMPK at the crossroads of circadian clocks and metabolism. Mol Cell Endocrinol. 2013 Feb 25;366(2):163-9.doi:10.1016/j.mce.2012.06.017.
Merkwirth C, Korwitz A, Martinelli P, Morbin M, Brönneke HS, Jordan SD, Rugarli EI, and Langer T. Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration. PLoS Genet. 2012;8(11):e1003021. doi: 10.1371/journal.pgen.1003021.
Jordan SD, Krüger M, Willmes DM, Redemann R, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC. Obesity-Induced Overexpression of miRNA-143 Inhibits Insulin-Stimulated AKT Activation and Impairs Glucose Metabolism. Nat Cell Biol. 2011 Apr;13(4):434-46. doi: 10.1038/ncb2211.
Jordan SD, Könner AC, Brüning JC. Sensing the fuels: Glucose- and lipid-signalling in the CNS controlling energy homeostasis. Cell Mol Life Sci. 2010 Oct;67(19):3255-73. doi: 10.1007/s00018-010-0414-7.
Bailly-Maitre B*, Belgardt BF*, Jordan SD*, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC. Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance. J Biol Chem. 2010 Feb 26;285(9):6198-207. doi: 10.1074/jbc.M109.056648. *These authors contributed equally
Rother E, Jordan SD, Bruning JC. [The importance of the brain for the regulation of energy and glucose metabolism]. Dtsch Med Wochenschr. 2009 May;134(20):1057-9. doi: 10.1055/s-0029-1222567. German.
Könner AC*, Janoschek R*, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC. (2007). Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab. 2007 Jun;5(6):438-49. * These authors contributed equally