Raz Bar-Ziv, Ph.D.

Post-doctoral Fellow

 

Research

I received my Bachelor’s degree in Biotechnology from Tel Aviv University, and my M.Sc and Ph.D from the Weizmann Institute of Science in Israel. During my graduate work in Professor Naama Barkai’s lab, I applied high-throughput sequencing based techniques to study the dynamics of chromatin and gene expression during DNA replication. On the chromatin level, I found that histone modifications are retrieved in a transcription-dependent time delay following DNA replication, and that a wave of H3K9 acetylation precedes the replication fork. On the level of gene expression, I showed that the expression of most genes is buffered during DNA replication, and found the first molecular link to the mechanism of this phenomenon. 

In the Dillin lab, I am broadly interested in how cells maintain protein homeostasis within different organelles, and the mechanisms responsible for the deterioration of this homeostasis during aging. Specifically, I am interested in studying how different tissues respond to stress, focusing on transcriptional regulation and rewiring that occurs during stress and aging.  

 

Publications

Bar-Ziv R*, Voichek Y*, Barkai N. 2016. Dealing with Gene-Dosage Imbalance during S Phase. Trends in Genetics. 32(11):717-723.

Voichek Y*, Bar-Ziv R*, Barkai N, 2016. A role for Rtt109 in buffering gene-dosage imbalance during DNA replication. Nucleus. 7(4):375-81

Bar-Ziv R*, Voichek Y*,  Barkai N, 2016, Chromatin dynamics during DNA replication. Genome Research. 26(9):1245-56.

Voichek Y*, Bar-Ziv R*, Barkai N, 2016, Expression homeostasis during DNA replication. Science. 351(6277):1087-90. 

Hornung G, Bar-Ziv R*, Rosin D, Tokuriki N, Tawfik DS, Oren M, Barkai N, 2012, Noise-mean relationship in mutated promoters. Genome Research. 22(12):2409-17.