Publications

Peer Reviewed Journal Articles:

Taylor RC, Dillin A. XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell. 2013;153(7):1435-47. PMID: 23791175. 
Watch the Video Abstract. 

Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A. FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell. 2013;12(3):518-22. PMID: 23551888

Vilchez D, Boyer L, Morantte I, Lutz, M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, and Dillin A. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature. 2012: 489(7415):304-8. PMID: 22972301.   

Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, RodriguesAPC, Manning G, and Dillin A.  RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature. 2012:389(7415):263-268. PMID: 22922647.

Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 2011;470(7334):404-8. PMID: 21331044.

Durieux J, Wolff S, Dillin A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell. 2011;144(1):79-91. PMID: 21215371.

Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, Dillin A. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell. 2010;9(2):126-34. PMID: 22360389.

Mair W, Panowski SH, Shaw RJ, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One. 2009;4(2):e4535. PMID: 19229346.

Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 2009;139(6):1157-69. PMID: 20005808.

Carrano AC, Liu Z, Dillin A*, Hunter T. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature. 2009;460(7253):396-9. * Corresponding author. PMID: 19553937.

Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007;447(7144):550-5. PMID: 17476212.

Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A, Yates JR, 3rd. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science. 2007;317(5838):660-3. PMID: 17673661.

Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science. 2006;313(5793):1604-10. PMID: 16902091.

Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell. 2006;124(5):1039-53. PMID: 16530049.

Raices M, Maruyama H, Dillin A, Karlseder J. Uncoupling of longevity and telomere length in C. elegans. PLoS Genet. 2005;1(3):e30. PMID: 16151516.

Hansen M, Hsu AL, Dillin A, Kenyon C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 2005;1(1):119-28. PMID: 16103914.

Venable JD, Dong MQ, Wohlschlegel J, Dillin A, Yates JR. Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra. Nature Methods. 2004;1(1):39-45. PMID: 15782151.

Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C. Rates of behavior and aging specified by mitochondrial function during development. Science. 2002;298(5602):2398-401.PMID: 12471266.

Dillin A, Crawford DK, Kenyon C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science. 2002;298(5594):830-4. PMID: 12399591.

Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science. 2002;295(5554):502-5. PMID: 11799246.

Dillin A, Rine J. Roles for ORC in M phase and S phase. Science. 1998;279(5357):1733-7. PMID: 9497294.

Dillin A, Rine J. Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae. Genetics. 1997;147(3):1053-62. PMID: 9383052.

McCracken AA, Karpichev IV, Ernaga JE, Werner ED, Dillin AG, Courchesne WE. Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor. Genetics. 1996;144(4):1355-62. PMID: 8978025.

Loo S, Laurenson P, Foss M, Dillin A, Rine J. Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae. Genetics. 1995;141(3):889-902. PMID: 8582634.

Fox CA, Loo S, Dillin A, Rine J. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. Genes & Development. 1995;9(8):911-24. PMID: 7774809.

Reviews, Perspectives, and Books:

Douglas PM, Dillin A. The disposable soma theory of aging in reverse. Cell Res. 2013. PMID: 24189044.

Vilchez D, Simic MS, Dillin A. Proteostasis and aging of stem cells. Trends in cell biology. 2013. PMID: 24094931.

Wolff S, Dillin A. Ageing: beneficial miscommunication. Nature. 2013;497(7450):442-3. PMID: 23698438.

Wilkinson DS, Taylor RC, Dillin A. Analysis of aging in Caenorhabditis elegans. Methods Cell Biol. 2012;107:353-81. PMID: 22226530.

Taylor RC, Dillin A. Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol. 2011;3(5). PMID: 21441594.

Dillin A, Cohen E. Ageing and protein aggregation-mediated disorders: from invertebrates to mammals. Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):94-8. PMID: 21115535.

Douglas PM, Dillin A. Protein homeostasis and aging in neurodegeneration. J Cell Biol. 2010;190(5):719-29. PMID: 2935559.

Dillin A. Andy Dillin: Using aging research to probe biology. Interview by Caitlin Sedwick. J Cell Biol. 2010;189(4):616-7. PMID: 20479463.

Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem. 2009;78:959-91. PMID: 19298183.

Panowski SH, Dillin A. Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol Metab. 2009;20(6):259-64. PMID: 19646896.

Mair W, Dillin A. Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem. 2008;77:727-54. PMID: 18373439.

Cohen E, Dillin A. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nature reviews Neuroscience. 2008;9(10):759-67. PMID: 18769445.

Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science. 2008;319(5865):916-9. PMID: 18276881.

Durieux J, Dillin A. Mitochondria and aging: dilution is the solution. Cell Metab. 2007;6(6):427-9. PMID: 18054312.

Wolff S, Dillin A. The trifecta of aging in Caenorhabditis elegans. Experimental gerontology. 2006;41(10):894-903. PMID: 16919905.

Aguilaniu H, Durieux J, Dillin A. Metabolism, ubiquinone synthesis, and longevity. Genes & development. 2005;19(20):2399-406. PMID: 16230529.

Dillin A, Rine J. On the origin of a silencer. Trends Biochem Sci. 1995;20(6):231-5. PMID: 7631420.