Full list of Dillin Lab Publications at PMID


Schinzel, RT, Higuchi-Sanabria, R, Shalem, O, Moehle, EA, Webster BM, Joe, L, Bar-Ziv, R, Frankino, PA, Durieux, J, Pender, C, Kelet, N, Kumar SS, Savalia, N, Chi, H, Nguyen N, Simic, M, Dillin A.  The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER Cell. 2019 Nov 21. PMID:  

Anderson EC, Frankino PA, Higuchi-Sanabria R, Yang Q, Bian Q, Podshivalova K, Shin A, Kenyon C, Dillin A, Meyer BJ.  X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.  

Dev Cell. 2019 Sep 4. PMID:  31495695

Frankino PA, Moehle EA, Dillin A.  Evolutionary Comeuppance: Mitochondrial Stress Awakens the Remnants of Ancient Bacterial Warfare.  Cell Metab. 2019 May 7.  PMID:  31067444  

Simic M, Moehle E, Schinzel, R, Lorbeer F, Halloran J, Heydari, K , Sanchez M, Jullié D , Hockemeyer D , Dillin A.  Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming.   Science Advances.  2019 April 20.

Youssar L, Wernet V, Hensel N, Yu X, Hildebrand HG, Schreckenberger B, Kriegler M, Hetzer B, Frankino P, Dillin A, Fischer R.  Intercellular communication is required for trap formation in the nematode-trapping fungus Duddingtonia flagrans.

PLoS Genet. 2019 Mar 27.  PMID:  30917129

Bar-Ziv R, Nguyen NT, Dillin A.  Vive ut Numquam Moriturus: Tweaking Translational Control to Regulate Longevity.  Mol Cell. 2019 Feb 21.  PMID:  30794792



Higuchi-Sanabria R, Paul JW, Durieux J, Benitez C, Frankino PA, Tronnes SU, Garcia G, Daniele JR, Monshietehadi S, Dillin A.  Spatial regulation of the actin cytoskeleton by HSF-1 dring aging.  Mol Biol Cell.  2018 Aug 22.  PMID:  30133343

Zhang, Q, Wu, X, Chen P, Liu, L, Xin, N, Tian Y, Dillin, A.  The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.   Cell.  2018 Aug 9.  PMID:  30057120

Daniele JR, Heydari K, Dillin A.  Mitochondrial Subtype Identification and Characterization.  Curr Protoc Cytome.  2018 July.  PMID:  29944197 

Simic MS, Dillin A.  The Lysosome, Elixir of Neural Stem Cell Youth.  Cell Stem Cell. 2018 May 3.  PMID:  29727677

Moehle EA, Shen K, Dillin A.  Mitochondrial Proteostasis in the Context of Cellular and Organismal Heath and Aging.  J Biol Chem. 2018 Apr 5.  PMID:  29622680 

 De Magalhaes Filho CD, Henriquez B, Seah NE, Evans RM, Lapierre LR, Dillin A.  Visible light reduces C. elegans longevity.  Nat Commun. 2018 Mar 2.  PMID:  29500338

Higuchi-Sanabria R, Frankino PA, Paul JW 3rd, Tronnes SU, Dillin A.  A Futile Battle? Protein Quality Control and the Stress of Aging.  Dev Cell. 2018 Jan 22.  PMID:  29401418


Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.

The Sense of Smell Impacts Metabolic Health and Obesity.  Cell Metab. 2017 Jul 5.  PMID:  28683287

Frakes AE, Dillin A.  The UPRER: Sensor and Coordinator of Organismal Homeostasis.  Mol Cell. 2017 Jun 15.  PMID:  28622521



Kim, HE, Durieux J, Grant A, Simic, M, Kohnz, R, Nomura, D, Riera, C, Sanchez, M, Kapernick, E, Wolff S, Dillin A.  Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.  Cell.  2016 Sept 8.  PMID: 27610574

Berendzen, KM, Durieux, J, Shao LW, Tian Y, Kim HE, Wolff S, Liu Y, Dillin A.  Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis.  Cell.  2016 Sept 8.  PMID: 26601575

Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA.  DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.

Dev Cell. 2017 Jul 10.  PMID:  28697336

Daniele JR, Esping DJ, Garcia G, Parsons LS, Arriaga EA, Dillin A.  "High-Throughput Characterization of Region-Specific Mitochondrial Function and Morphology".  Sci Rep. 2017 Jul 27.  PMID:  28751733

Riera, C.E., Merkwirth C., de Magalhaes Filho, C.D.and Dillin, A. (2016). Signaling Networks Determining Life Span for Volume 85 of the Annual Review of Biochemistry. Annu Rev Biochem. 2016 Jun 2;85:35-64.  PMID: 27294438

Steffen, KK, Dillin A.  A Ribosomal Perspective on Proteostasis and Aging.  Cell Metabolism.  2016 June 14.  PMID: 27304502

Riera, C.E., and Dillin, A. (2016). Emerging role of sensory perception in aging and metabolism (2015).Trends Endocrinol Metab. 2016 May;27(5):294-303.  PMID: 27067041.

Daniele JR, Heydari K, Arriaga EA, Dillin A.  Identification and characterization of mitochondrial subtypes in C. elegans via analysis of individual mitochondria by flow cytometry.  Anal Chem. 2016 May 23.  PMID: 27210103

Merkwirth CJovaisaite VDurieux JMatilainen OJordan SDQuiros PMSteffen KKWilliams EGMouchiroud LTronnes SUMurillo VWolff SCShaw RJAuwerx J, Dillin A.  Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.  Cell. 2016 May 165, 1–15.  PMID: 27133168

Tian Y, Garcia G, Bian Q, Steffen KK, Joe L, Wolff S, Meyer BJ, Dillin A.  Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPRmt.  Cell.  2016 May 165, 1–12.  PMID: 27133166



Seah NE, de Magalhaes Filho CD, Petrashen AP, Henderson HR, Laguer J, Gonzalez J, Dillin A, Hansen M, Lapierre LR.  Autophagy-mediated longevity is modulated by lipoprotein biogenesis.  Autophagy. 2015 Dec 15:0. PMID: 26671266

Riera, C.E., and Dillin, A. (2015). Can aging be "drugged"? Nat. Med.2015 Dec 8;21(12):1400-5.  PMID: 26646496.

Douglas, P, Baird N, Simic M, Uhlein S, McCormick M, Kennedy B, Dillin A.  Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Logevity.  Cell Reports 12, 1196–1204 August 18, 2015.  PMID: 26257177

Heimbucher T, Liu Z, Bossard C, McCloskey R, Carrano A, Riedel C. Tanasa B, Klammt C, Fonslow B, Riera C, Lillemeier B, Kemphues K, Yates J, O'Shea C. Hunter T, Dillin A.  The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function In Metabolism and Longevity.  Cell Metabolism 22, 151-163, July 7, 2015.  PMID:  26154057

Riera CE, Dillin A.  Tipping the metabolic scales towards increased longevity in mammals.  Nat Cell Biolo. 2015 Feb 27;17(3):196-203.  PMID:  25720959

Schinzel R, Dillin A. Endocrine aspects of organelle stress - cell non-autonomous signaling of mitochondria and the ER. Curr Opin Cell Biol. 2015 Feb 9;33C:102-110. PMID: 25677685.

Wilkinson DS, Jariwala JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. Mol Cell. 2015 Jan 8;57(1):55-68. PMID: 25544559.



Vilchez D, Seaz I, Dillin A.  The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nat Commun. 2014 Dec 8;5:5659.  PMID:  25482515.

Dillin A. Profile of Kazutoshi Mori and Peter Walter, 2014 Lasker Basic Medical Research awardees: The unfolded protein response. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17696-7. PMID: 25480547.

Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ, Wolff SC, Yates JR 3rd, Manning G, Dillin A. HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span. Science. 2014 Oct 17;346(6207):360-3. PMID: 25324391.

Mardones P, Dillin A, Hetz C. Cell-nonautonomous control of the UPR: mastering energy homeostasis. Cell Metab. 2014 Sep 2;20(3):385-7. PMID: 25185942.

Patti GJ, Tautenhahn R, Johannsen D, Kalisiak E, Ravussin E, Brüning JC, Dillin A, Siuzdak G. Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension. Metabolomics. 2014 Aug 1;10(4):737-743. PMID: 25530742.

Fonslow BR, Moresco JJ, Tu PG, Aalto AP, Pasquinelli AE, Dillin AG, Yates III, JR. Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes. WormBook. 2014:1-18. PMID: 24967700.

Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A. TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. Cell. 2014;157(5):1023-36. PMID: 24855942.

Carrano AC, Dillin A, Hunter T. A Kruppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. Nat Commun. 2014;5:3772. PMID: 24805825.

Wolff S, Dillin A. Cell biology: The stressful influence of microbes. Nature. 2014;508(7496):328-9. PMID: 24695220.

Wolff S, Weissman JS, Dillin A. Differential scales of protein quality control. Cell. 2014;157(1):52-64. PMID: 24679526.

Douglas PM, Dillin A. The disposable soma theory of aging in reverse. Cell Res. 2014. PMID: 24189044.

Taylor RC, Berendzen KM, Dillin A. Systemic stress signalling: understanding the cell non-autonomous control of proteostasis. Nat Rev Mol Cell Biol. 2014;15(3):211-7. PMID: 24556842.

Dillin A, Gottschling DE, Nystrom T. The good and the bad of being connected: the integrons of aging. Curr Opin Cell Biol.;26:107-12. PMID: 24529252.



Taylor RC, Dillin A. XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell. 2013;153(7):1435-47. PMID: 23791175. Watch the Video Abstract. 

le Coutre J, Mattson MP, Dillin A, Friedman J, Bistrian B. Nutrition and the biology of human ageing: cognitive decline/food intake and caloric restriction. J Nutr Health Aging. 2013;17(8):717-20. PMID: 24097030. 

Vilchez D, Simic MS, Dillin A. Proteostasis and aging of stem cells. Trends in cell biology. 2013. PMID: 24094931.

Wolff S, Dillin A. Ageing: beneficial miscommunication. Nature. 2013;497(7450):442-3. PMID: 23698438.

Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A. FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell. 2013;12(3):518-22. PMID: 23551888

Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun. 2013;4:2267. PMID: 23925298.

Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol. 2013 Jul;15(7):741-50. PMID: 23685627.

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013 May;15(5):491-501. PMID: 23604319.



Vilchez D, Boyer L, Morantte I, Lutz, M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, and Dillin A. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature. 2012: 489(7415):304-8. PMID: 22972301.   

Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, RodriguesAPC, Manning G, and Dillin A.  RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature. 2012:389(7415):263-268. PMID: 22922647.

Parrish AR, She X, Xiang Z, Coin I, Shen Z, Briggs SP, Dillin A, Wang L. Expanding the genetic code of Caenorhabditis elegans using bacterial aminoacyl-tRNA synthetase/tRNA pairs. ACS Chem Biol. 2012 Jul 20;7(7):1292-302. PMID: 22554080.

Wilkinson DS, Taylor RC, Dillin A. Analysis of aging in Caenorhabditis elegans. Methods Cell Biol. 2012;107:353-81. PMID: 22226530.



Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 2011;470(7334):404-8. PMID: 21331044.

Durieux J, Wolff S, Dillin A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell. 2011;144(1):79-91. PMID: 21215371.

Dillin A, Cohen E. Ageing and protein aggregation-mediated disorders: from invertebrates to mammals. Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):94-8. PMID: 21115535.

Taylor RC, Dillin A. Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol. 2011;3(5). PMID: 21441594.

Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell. 2011; 44(4):532-44. PMID: 22099302. 

Mair W, Steffen KK, Dillin A. SIP-ing the elixir of youth. Cell. 2011;146(6):859-60. PMID: 21925309.

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011;331(6016):456-61. PMID: 21205641.

Dillin A, Cohen E. Ageing and protein aggregation-mediated disorders: from invertebrates to mammals. Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):94-8. PMID: 21115535. 



Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, Dillin A. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell. 2010;9(2):126-34. PMID: 22360389.

Douglas PM, Dillin A. Protein homeostasis and aging in neurodegeneration. J Cell Biol. 2010;190(5):719-29. PMID: 2935559.

Dillin A. Andy Dillin: Using aging research to probe biology. Interview by Caitlin Sedwick. J Cell Biol. 2010;189(4):616-7. PMID: 20479463.



Mair W, Panowski SH, Shaw RJ, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One. 2009;4(2):e4535. PMID: 19229346.

Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 2009;139(6):1157-69. PMID: 20005808.

Carrano AC, Liu Z, Dillin A*, Hunter T. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature. 2009;460(7253):396-9. * Corresponding author. PMID: 19553937.

Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem. 2009;78:959-91. PMID: 19298183.

Panowski SH, Dillin A. Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol Metab. 2009;20(6):259-64. PMID: 19646896.

Dillin A. Caenorhabditis elegans in Translational Research. Annu Rev Cell Dev Biol. 2009. PMID: 19575653.

Shaw R, Dillin A. PPTR-1 counterAkts insulin signaling. Cell. 2009;136(5):816-8. PMID: 19269361.



Mair W, Dillin A. Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem. 2008;77:727-54. PMID: 18373439.

Cohen E, Dillin A. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nature reviews Neuroscience. 2008;9(10):759-67. PMID: 18769445.

Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science. 2008;319(5865):916-9. PMID: 18276881.

Raices M, Verdun RE, Compton SA, Haggblom CI, Griffith JD, Dillin A, Karlseder J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by
distinct proteins. Cell. 2008;132(5):745-57. PMID: 18329362.



Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007;447(7144):550-5. PMID: 17476212.

Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A, Yates JR, 3rd. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science. 2007;317(5838):660-3. PMID: 17673661.

Durieux J, Dillin A. Mitochondria and aging: dilution is the solution. Cell Metab. 2007;6(6):427-9. PMID: 18054312.



Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science. 2006;313(5793):1604-10. PMID: 16902091.

Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell. 2006;124(5):1039-53. PMID: 16530049.

Wolff S, Dillin A. The trifecta of aging in Caenorhabditis elegans. Experimental gerontology. 2006;41(10):894-903. PMID: 16919905.



Raices M, Maruyama H, Dillin A, Karlseder J. Uncoupling of longevity and telomere length in C. elegans. PLoS Genet. 2005;1(3):e30. PMID: 16151516.

Hansen M, Hsu AL, Dillin A, Kenyon C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 2005;1(1):119-28. PMID: 16103914.

Aguilaniu H, Durieux J, Dillin A. Metabolism, ubiquinone synthesis, and longevity. Genes & development. 2005;19(20):2399-406. PMID: 16230529.



Venable JD, Dong MQ, Wohlschlegel J, Dillin A, Yates JR. Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra. Nature Methods. 2004;1(1):39-45. PMID: 15782151.


Prior to 2004:

Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C. Rates of behavior and aging specified by mitochondrial function during development. Science. 2002;298(5602):2398-401.PMID: 12471266.

Dillin A, Crawford DK, Kenyon C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science. 2002;298(5594):830-4. PMID: 12399591.

Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science. 2002;295(5554):502-5. PMID: 11799246.

Dillin A, Rine J. Roles for ORC in M phase and S phase. Science. 1998;279(5357):1733-7. PMID: 9497294.

Dillin A, Rine J. Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae. Genetics. 1997;147(3):1053-62. PMID: 9383052.

McCracken AA, Karpichev IV, Ernaga JE, Werner ED, Dillin AG, Courchesne WE. Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor. Genetics. 1996;144(4):1355-62. PMID: 8978025.

Loo S, Laurenson P, Foss M, Dillin A, Rine J. Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae. Genetics. 1995;141(3):889-902. PMID: 8582634.

Fox CA, Loo S, Dillin A, Rine J. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. Genes & Development. 1995;9(8):911-24. PMID: 7774809.

Dillin A, Rine J. On the origin of a silencer. Trends Biochem Sci. 1995;20(6):231-5. PMID: 7631420.