Hyun-eui Kim, Ph.D.

Post-doctoral Fellow
I finished my Ph.D. at UT Southwestern Medical Center in Dallas. There, I studied a mitochondria-initiated apoptosis pathway, specifically looking at the molecular mechanisms behind the activation mechanism of apoptosome. In the Dillin lab, I am examining the mechanisms of protein aggregation and proteotoxicity using Amyoid beta and poly-Q aggregation models of C.elegans and mice.


  • Kim, HE, Grant A, Simic, M, Kohnz, R, Nomura, D, Durieux J, Riera, C, Sanchez, M, Kapernick, E, Wolff, S, Dillin, A.  Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.  Cell. 2016 Sept 8.
  • Du D, Murray E, Cohen E, Kim HE, Simkovsky R, Dillin A, Kelly JW. A kinetic aggregation assay that enables highly sensitive Ab semiquantification in cells and tissues. Biochemistry 2011 Mar 15; 50(10):1067-17.
  • Van Ham TJ, Homberg M, Van der Goot A, Teuling E, Garcia-Arencibia M, Kim HE, Du D, Van Bergeijk, Thijssen KL, Wiersma M, Burggraaff R, van Rheenen J, van Veluw GJ, Hofstra R MW, Rubinsztein DC, Nollen E AA. Identification of Moag-4/SERF as a regulator of age-related proteotoxicity. Cell. 2010 Aug 20;142(4):601-612.
  • Kim HE, Wang X. CAS and PHAPI Positively Regulate Apoptosome formation by Enhancing Nucleotide Exchange on Apaf-1. Mol. Cell 2008 Apr 24; 30(2):239-47.
  • Kim HE, Du F, Fang M, Wang X. Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proc Natl Acad Sci U S A. 2005 Oct 26; [Epub ahead of print]
  • Liu Q, Rand TA, Kalidas S, Du F, Kim HE, Smith DP, Wang X. R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science. 2003 Sep 26;301(5641):1921-5.
  • Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science. 2003 Jan 10;299(5604):223-6.
  • Kim HE, Yoon SY, Lee JE, Choi WS, Jin BK, Oh TH, Markelonis GJ, Chun SY, Oh YJ. MPP(+) downregulates mitochondrially encoded gene transcripts and their activities in dopaminergic neuronal cells: protective role of Bcl-2. Biochem Biophys Res Commun. 2001 Aug 24;286(3):659-65.
  • Kim HE, Oh JH, Lee SK, Oh YJ. Ginsenoside RH-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway. Life Sci. 1999;65(3):PL33-40.
  • Joo CK, Cho KS, Kim HE, Choi JS, Oh YJ. Protective role for Bcl-2 in experimentally induced cell death of bovine corneal endothelial cells. Ophthalmic Research. 1999: 31(4):287-96.