Slide 26 of 31
Notes:
- Like other cancers, PC arises from a series of genetic alterations.
- The hAR is a protein that binds androgens and translocates them to the nucleus to eventually induce the transcription of certain genes.
- CAG repeats: elimination of repeats increased transcriptional activity of hAR. The CAG repeat sequence inhibits transcription of hAR. Fewer CAG repeats correlates with a higher incidence and mortality from prostate cancer.
- Asian men _ more repeats
- African American men _ less repeats
