Referenced Textbook (recommended, not required): Scott F. Gilbert, Developmental Biology, Ninth (2010) or Eighth Edition (2006)

I. Professor Michael Levine

First third of the course: Introduction to developmental biology, patterning of the Drosophila embryo

Lecture 1, Tuesday, Jan 22. Nuclear equivalence and reprogramming. (lecture notes, supplemental reading, Pubmed for Yamanaka iPS cell paper)
Lecture 2, Thursday, Jan 24. Three strategies for differential gene activity. (lecture notes)
Lecture 3, Tuesday, Jan 29. Germ cells and oogenesis. (lecture notes)
Lecture 4, Thursday, Jan 31. Segmentation of the Drosophila embryo. (lecture notes)
Lecture 5, Tuesday, Feb 5. Dorsal-ventral patterning of the Drosophila embryo. (lecture notes)
Lecture 6, Thursday, Feb 7. Homeotic genes and conservation of Hox genes. (lecture notes)
Lecture 7, Tuesday, Feb 12. Finish Hox genes. (finish Lecture 6 notes)
Lecture 8, Thursday, Feb 14. Ciona intestinalis development and Midterm 1 review.

Midterm I: Tuesday, February 19, 11:10-12:30 in 160 Kroeber.

 

II. Professor John Gerhart

Middle third of the course: Early development of vertebrates from the oocyte to the late neurula stage.
Referenced Textbook (recommended, not required): Scott F. Gilbert, Developmental Biology, Ninth (2010) or Eighth Edition (2006)

Lecture 1, Thursday, Feb 21. Chordates and vertebrates: defining traits, outline of amphibian development 6-11 (42-46; 216-217; 722; 725-731; 742-744) (lecture slides, handout, movie of several cleavages in Xenopus, movie of early Xenopus development)
Lecture 2, Tuesday, Feb 26. Fate, competence, specification, determination. Discovery of Spemann’s organizer. 19-21; 112-113; 241-244; 255-256 (10-13; 25-31; 57-62. 304-306) (lecture slides, handout)
Lecture 3, Thursday, Feb 28. Cytoplasmic localizations, cortical rotation, and axis formation in the amphibian egg 92-93; 242-244 (81-83; 136; 153-158; 615-619 and 291-294; 302-310).(lecture slides, handout)
Lecture 4, Tuesday, Mar 5. Endo-mesoderm induction 94-95; 257-262 (155-158; 311-312). (lecture slides, handout)
Lecture 5, Thursday, Mar 7. Formation of Spemann's organizer 261-263 (312-324). (lecture slides, handout)
Lecture 6, Tuesday, Mar 12. Gastrulation 9; 244-252 (29; 295-302). (lecture slides, handout)
Lecture 7, Thursday, Mar 14. Neural induction and neurulation 79-80; 263-272; 336 (312-324; 375-381). (lecture slides, handout)
Lecture 8, Tuesday, Mar 19. Chick development and extraembryonic development 287-297; 480-482 (336-348; 501-503; 45). (lecture slides, handout)
Lecture 9, Thursday, Mar 21. Mammalian early development 300-313 (92-96; 348-368). (lecture slides, handout)

Spring Break March 25-29

Lecture 1, Tuesday, Apr 2.  Professor Richard Harland: Summary of amniote and mammalian gastrulation, overview of organogenesis – material not on Midterm 2 (lecture slides, handout)

Review times and locations posted on homepage.
Midterm 2: Thursday, Apr 4, 11:10-12:30. (Note: Midterm 2 comes after Professor Harland’s Lecture 1 on April 2nd, but will not contain material from that lecture.)

 

III. Professor Richard Harland

Final third of the course: late development of vertebrates--organogenesis, cytodifferentiation. Lecture notes and reading assignments will be posted later.
(Lecture 1,Tuesday, Apr 2.  Summary of amniote and mammalian gastrulation, Overview of organogenesis [see above])

(Midterm 2: Thursday, Apr 4 [see above])

Lecture 2, Tuesday, Apr 9.  Embryonic signals and mesoderm induction. (lecture slides, handout: .pdf, .doc)
Lecture 3, Thursday, Apr 11.  Neural Tube: induction, morphogenesis, patterning, and differentiation. (lecture slides, handout: .pdf, .doc)
Lecture 4, Tuesday, Apr 16. Neural Tube: cont'd. (lecture slides, handout: .pdf, .doc)
Lecture 5, Thursday, Apr 18.  Somite differentiation. (lecture slides, handout)
Lecture 6, Tuesday, Apr 23.   Neural crest and placodes. (lecture slides, handout)
Lecture 7, Thursday, Apr 25. Muscle development. (lecture slides, handout)
Lecture 8, Tuesday, Apr 30.  Limb development. (lecture slides, handout)
Lecture 9, Thursday, May 2. Endodermal derivatives and kidney. Summary of organogenesis (lecture slides, handout)

Reading/Review/Recitation week May 6-10.
     Prof. Harland will hold a 2-hour review session during lecture time on Tuesday, May 7, in 160 Kroeber.

Final Exam: Final Exam Group 13 - Thursday, May 16, 2013, 8–11am, in 2040 VLSB.