Symposium Overview

Background Reading: Morning Session

Genome-wide transcription and the implications for genomic organization.
Kapranov P, Willingham AT, Gingeras TR.
Nat Rev Genet. 2007 Jun;8(6):413-23.

Evolution and functions of long noncoding RNAs.
Ponting CP, Oliver PL, Reik W.
Cell. 2009 Feb 20;136(4):629-41.

Long noncoding RNAs: functional surprises from the RNA world.
Wilusz JE, Sunwoo H, Spector DL.
Genes Dev. 2009 Jul 1;23(13):1494-504.

Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome.
Lee JT.
Genes Dev. 2009 Aug 15;23(16):1831-42.

Background Reading: Afternoon Session

MicroRNAs: target recognition and regulatory functions.
Bartel DP.
Cell. 2009 Jan 23;136(2):215-33.

Small RNA metabolism in Arabidopsis.
Ramachandran V, Chen X.
Trends Plant Sci. 2008 Jul;13(7):368-74.

Biogenesis of small RNAs in animals.
Kim VN, Han J, Siomi MC.
Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-39.

CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA.
Marraffini LA, Sontheimer EJ.
Science. 2008 Dec 19;322(5909):1843-5.

Additional Reading:

Long non-coding RNAs: insights into functions.
Mercer TR, Dinger ME, Mattick JS.
Nat Rev Genet. 2009 Mar;10(3):155-9.

The genetic signatures of noncoding RNAs.
Mattick JS.
PLoS Genet. 2009 Apr;5(4):e1000459.

Structured non-coding RNAs and the RNP Renaissance.
Hogg JR, Collins K.
Curr Opin Chem Biol. 2008 Dec;12(6):684-9

Small silencing RNAs: an expanding universe.
Ghildiyal M, Zamore PD.
Nat Rev Genet. 2009 Feb;10(2):94-108

Small RNAs as guardians of the genome.
Malone CD, Hannon GJ.
Cell. 2009 Feb 20;136(4):656-68.

Nobel lectures in Physiology or Medicine, 2006
Fire, A. Z.
Mello, C. C.

CRISPR-based adaptive and heritable immunity in prokaryotes.
van der Oost J, Jore MM, Westra ER, Lundgren M, Brouns SJ.
Trends Biochem Sci. 2009 Aug;34(8):401-7.

Regulatory RNAs in bacteria.
Waters LS, Storz G.
Cell. 2009 Feb 20;136(4):615-28.