News and Events Department News QB3 team finds that enzyme’s wraparound structure prevents misfolding
Professors of biochemistry and molecular biology Susan Marqusee and Carlos Bustamante show in new research that, in T4 lysozyme — an enzyme related to one responsible for a form of amyloidosis — a subtle detail of topology ensures that the protein either folds all at once or not at all, avoiding dangerous intermediates.
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Photo courtesy of Eva Nogales
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