Papers

2017
Actin-based motility and cell-to-cell spread of bacterial pathogens
Lamason RL, Welch MD.
Curr Opin Microbiol 35: 48-57 (2017)
[ PubMed Abstract | Full Text ]


2016
Actin-based motility of bacterial pathogens: mechanistic diversity and its impact on virulence
Choe JE, Welch MD.
Pathog Dis 74: ftw099 (2016)
[ PubMed Abstract | Full Text ]

Rickettsia Sca4 reduces vinculin-mediated intercellular tension to promote spread
Lamason RL, Bastounis E, Kafai NM, Serrano R, Del Álamo JC, Theriot JA, Welch MD.
Cell 167: 670-683.e10 (2016)
[ PubMed Abstract | Full Text ]

Rab1 recruits WHAMM during membrane remodeling but limits actin nucleation
Russo AJ, Mathiowetz AJ, Hong S, Welch MD, Campellone KG.
Mol Biol Cell 27: 967-978 (2016)
[ PubMed Abstract | Full Text ]


2015
Why should cell biologists study microbial pathogens?
Welch MD.
Mol Biol Cell 26: 4295-4301 (2015)
[ PubMed Abstract | Full Text ]

Virulent Burkholderia species mimic host actin polymerases to drive actin-based motility
Benanti EL, Nguyen CM, Welch MD.
Cell 161: 348-360 (2015)
[ PubMed Abstract | Full Text | Videos ]

Cell migration, freshly squeezed
Welch MD.
Cell 160: 581-582 (2015)
[ PubMed Abstract | Full Text ]


2014
A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis
Engström P, Krishnan KS, Ngyuen BD, Chorell E, Normark J, Silver J, Bastidas RJ, Welch MD, Hultgren SJ, Wolf-Watz H, Valdivia RH, Almqvist F, Bergström S.
mBio 6: e02304-14 (2014)
[ PubMed Abstract | Full Text ]

Editorial overview: Cell architecture: Cellular organization and function
Biggins S, Welch MD.
Curr Opin Cell Biol 26: v-vii (2014)
[ PubMed Abstract | Full Text ]

Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion
Mueller J, Pfanzelter J, Winkler C, Narita A, Le Clainche C, Nemethova M, Carlier MF, Maeda Y, Welch MD, Ohkawa T, Schmeiser C, Resch GP, Small JV.
PLoS Biology 12: e1001765 (2014)
[ PubMed Abstract | Full Text ]

Rickettsia actin-based motility occurs in distinct phases mediated by different actin nucleators
Reed SC, Lamason RL, Risca VI, Abernathy E, Welch MD.
Curr Biol 24: 98-103 (2014)
[ PubMed Abstract | Full Text | Videos]


2013
Arp2/3-mediated actin-based motility: a tail of pathogen abuse
Welch MD, Way M.
Cell Host Microbe 14: 242-255 (2013)
[ PubMed Abstract | Full Text ]


2012
Establishing intracellular infection: escape from the phagosome and intracellular colonization (Rickettsiaceae)
Welch MD, Reed SC, Haglund CM.
Chapter 5 of Intracellular Pathogens II: Rickettsiales, edited by G. H. Palmer and A. F. Azad (2012)
[ Request by emailing welch@berkeley.edu ]

Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling
Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG, Wang HW.
J Cell Biol 199: 111-124 (2012)
[ PubMed Abstract | Full Text ]

Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex
Duleh SN, Welch MD.
Cytoskeleton 69: 1047-1058 (2012)
[ PubMed Abstract | Full Text | Videos ]




Expression of an epitope-tagged virulence protein in Rickettsia parkeri using transposon insertion
Welch MD, Reed SC, Lamason RL, Serio AW.
PLoS One 7: e37310 (2012)
[ PubMed Abstract | Full Text ]

The nuclear localization of actin requires AC102 in Autographa californica M nucleopolyhedrovirus-infected cells
Gandhi KM, Ohkawa T, Welch MD, Volkman LE.
J Gen Virol 93: 1795-1803 (2012)
[ PubMed Abstract | Full Text ]

Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic E.coli
Campellone KG, Siripala AD, Leong JM, Welch MD.
J Biol Chem 287: 20613-20624 (2012)
[ PubMed Abstract | Full Text ]

Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway
Reed SC, Serio AW, Welch MD.
Cell Microbiol 14: 529-545 (2012)
[ PubMed Abstract | Full Text | Videos ]


2011
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase
Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH.
Autophagy 7:17-26 (2011)
[ PubMed Abstract | Full Text ]

The actin nucleation factor JMY is a negative regulator of neuritogenesis
Firat-Karalar EN, Hsiue PP, Welch MD.
Mol Biol Cell 22: 4563-4574 (2011)
[ PubMed Abstract | Full Text | Video ]

Pathogens and polymers: Microbe-host interactions illuminate the cytoskeleton
Haglund CM, Welch MD.
J Cell Biol 195: 7-17 (2011)
[ PubMed Abstract | Full Text ]

New mechanisms and functions of actin nucleation.
Firat-Karalar EN, Welch MD.
Curr Opin Cell Biol 23: 4-13 (2011)
[ PubMed Abstract | Full Text ]


2010
Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility.
Haglund CM, Choe JE, Skau CT, Kovar DR, Welch MD.
Nat Cell Biol 12: 1057-1063 (2010)
[ PubMed Abstract | Full Text | Videos ]





Actin-based motility drives baculovirus transit to the nucleus and cell surface.
Ohkawa T, Volkman LE, Welch MD.
J Cell Biol 190: 187-195 (2010)
[ PubMed Abstract | Full Text | Videos ]





Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia.
Serio AW, Jeng RL, Haglund CM, Reed SC, Welch MD.
Cell Host Microbe 7: 388-398 (2010)
[ PubMed Abstract | Full Text | Videos ]





An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability.
Goley ED, Rammohan A, Znameroski EA, Firat-Karalar EN, Sept D, Welch MD.
Proc Natl Acad Sci U S A 107: 8159-8164 (2010)
[ PubMed Abstract | Full Text | Video ]

A nucleator arms race: cellular control of actin assembly.
Campellone KG, Welch MD.
Nat Rev Mol Cell Biol 11: 237-251 (2010)
[ PubMed Abstract | Full Text ]

WASH and the Arp2/3 complex regulate endosome shape and trafficking.
Duleh SN, Welch MD.
Cytoskeleton 67: 193-206 (2010)
[ PubMed Abstract | Full Text | Video ]





2008
Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.
Campellone KG, Cheng HC, Robbins D, Siripala AD, McGhie EJ, Hayward RD, Welch MD, Rosen MK, Koronakis V, Leong JM.
PLoS Pathog 4: e1000191 (2008)
[ PubMed Abstract | Full Text ]

WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport.
Campellone KG, Webb NJ, Znameroski EA, Welch MD.
Cell 134: 148-161 (2008)
[ PubMed Abstract | Full Text | Videos ]





2007
Snapshot: Actin Regulators II.
Siripala AD, Welch MD.
Cell 128: 1014 (2007)
[ PubMed Abstract | Full Text ]

Snapshot: Actin Regulators I.
Siripala AD, Welch MD.
Cell 128: 626 (2007)
[ PubMed Abstract | Full Text ]


2006
Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein.
Goley ED, Ohkawa T, Mancuso J, Woodruff JB, D'Alessio JA, Cande WZ, Volkman LE, Welch MD.
Science 314, 464-467 (2006)
[ PubMed Abstract | Full Text | Videos ]

The ARP2/3 complex: an actin nucleator comes of age.
Goley ED, Welch MD.
Nat Rev Mol Cell Biol 7, 713-726 (2006)
[ PubMed Abstract | Full Text ]





Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation.
Martin AC, Welch MD, Drubin DG.
Nat Cell Biol 8, 826-833 (2006)
[ PubMed Abstract | Full Text ]

A role for cortactin in Listeria monocytogenes invasion of NIH 3T3 cells, but not in its intracellular motility.
Barroso C, Rodenbusch SE, Welch MD, Drubin DG.
Cell Motil Cytoskeleton 63, 231-43 (2006).
[ PubMed Abstract | Full Text ]


2005
NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein.
Kreishman-Deitrick M, Goley ED, Burdine L, Denison C, Egile C, Li R, Murali N, Kodadek TJ, Welch MD, Rosen MK.
Biochemistry 44, 15247-56 (2005)
[ PubMed Abstract | Full Text ]

Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration.
Bodin S, Welch MD.
Mol Biol Cell 16, 5773-83 (2005)
[ PubMed Abstract | Full Text | Videos ]

Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei.
Stevens MP, Stevens JM, Jeng RL, Taylor LA, Wood MW, Hawes P, Monaghan P, Welch MD, Galyov EE.
Mol Microbiol. 56, 40-53 (2005)
[ PubMed Abstract | Full Text ]

Actin-based motility of intracellular pathogens.
Gouin E, Welch MD, Cossart P.
Curr Opin Microbiol. 8, 35-45 (2005)
[ PubMed Abstract | Full Text ]

Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function.
Martin AC, Xu XP, Rouiller I, Kaksonen M, Sun Y, Belmont L, Volkmann N, Hanein D, Welch M, Drubin DG.
J Cell Biol. 168, 315-28 (2005)
[ PubMed Abstract | Full Text ]


2004
Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor.
Goley ED, Rodenbusch SE, Martin AC, Welch MD.
Mol Cell. 16, 269-79 (2004)
[ PubMed Abstract | Full Text ]

A Rickettsia WASP-like protein activates the Arp2/3 complex and mediates actin-based motility.
Robert L. Jeng, Erin D. Goley, Joseph A. D'Alessio, Oleg Y. Chaga, Tatyana M. Svitkina, Gary G. Borisy, Robert A. Heinzen and Matthew D. Welch.
Cell Microbiol. 6, 761-769 (2004)
[ PubMed Abstract | Full Text | Video ]


2003
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Edward A. Miao, Mitchell Brittnacher, Andrea Haraga, Robert L. Jeng, Matthew D. Welch and Samuel I. Miller.
Mol. Microbiol. 48, 401-415 (2003)
[ PubMed Abstract | Full Text ]

Formation of filopodia-like bundles in vitro from a dendritic network.
Danijela Vignjevic, Defne Yarar, Matthew D. Welch, John Peloquin, Tatyana Svitkina and Gary G. Borisy.
J Cell Biol. 160, 951-62 (2003)
[ PubMed Abstract | Full Text ]

Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility.
Luisa M. Stamm, J. Hiroshi Morisaki, Lian-Yong Gao, Robert L. Jeng, Kent L. McDonald, Robyn Roth, Sunao Takeshita, John Heuser, Matthew D. Welch and Eric J. Brown.
J Exp Med. 198, 1361-1368 (2003)
[ PubMed Abstract | Full Text ]


2002
Motility determinants in WASP family proteins.
Defne Yarar, Joseph A. D'Alessio, Robert L. Jeng and Matthew D. Welch.
Mol. Biol. Cell 13, 4045-4059 (2002)
[ PubMed Abstract | Full Text | pdf file ]

Cellular Control of Actin Nucleation.
Matthew D. Welch and R. Dyche Mullins.
Annu. Rev Cell Dev. Biol 18, 247-288 (2002)
[ PubMed Abstract | Full Text | pdf file ]

Turning on the Arp2/3 complex at atomic resolution.
Elizabeth L. Borths and Matthew D. Welch.
Structure 10, 131-135 (2002)
[ PubMed Abstract | Full Text | pdf file ]


2001
Reconstitution of human Arp2/3 complex reveals critical roles for individual subunits in complex structure and activity.
Helene Gournier, Erin D. Goley, Hanspeter Niederstrasser, Thong Trinh and Matthew D. Welch.
Mol. Cell 8, 1041-1052 (2001)
[ PubMed Abstract | Full Text | pdf file ]

Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility.
Justin Skoble, Victoria Auerbuch, Erin D. Goley, Matthew D. Welch and Daniel A. Portnoy.
J. Cell Biol. 155, 89-100 (2001)
[ PubMed Abstract | Full Text | pdf file ]

Actin and endocytosis - no longer the weakest link.
Robert L. Jeng and Matthew D. Welch.
Curr. Biol 9, R691-R694 (2001)
[ PubMed Abstract | Full Text | pdf file ]

Systematic mutational analysis of the amino-terminal domain of ActA reveals novel functions in actin-based motility.
Peter Lauer, Julie A. Theriot, Justin Skoble, Matthew D. Welch and Daniel A. Portnoy.
Molec Microbiol 42, 1163-1177 (2001)
[ PubMed Abstract | Full Text | pdf file ]


2000
Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and Listeria monocytogenes motility.
Justin Skoble, Daniel A. Portnoy and Matthew D. Welch.
J. Cell Biol. 150, 527-537 (2000).
[ PubMed Abstract | Full Text | pdf file ]


1999
The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex.
Defne Yarar, Wayne To, Arie Abo and Matthew D. Welch.
Current Biology 9, 555-558 (1999)
[ PubMed Abstract | Full Text | pdf file ]




The world according to Arp: regulation of actin nucleation by the Arp2/3 complex.
Matthew D. Welch.
Trends in Cell Biology 9, 423-427 (1999)
[ PubMed Abstract | Full Text | pdf file ]


1998
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.
Matthew D. Welch, Jody Rosenblatt, Jusin Skoble, Daniel A. Portnoy and Timothy J. Mitchison.
Science 281, 105-108 (1998)
[ PubMed Abstract | Full Text | pdf file ]


1997
The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.
Matthew D. Welch, Angela H. DePace, Suzie Verma, Akihiro Iwamatsu and Timothy J. Mitchison.
J Cell Biol. 138, 375-384 (1997)
[ PubMed Abstract | Full Text | pdf file ]

Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.
Matthew D. Welch, Akihiro Iwamatsu and Timothy J. Mitchison.
Nature 385, 265-269 (1997)
[ PubMed Abstract | Full Text ]
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