We study the interactions between bacteria and the immune system

Infection is a constant threat to all living things. Most of us are oblivious of this threat because our immune system does a remarkable job of eliminating infectious microbes before they cause symptoms. We are interested in understanding how the immune system detects the presence of infectious microbes. We use all the tools of modern molecular biology, biochemistry, and genetics, to dissect the fundamental mechanisms that provide host defense. We are also interested in understanding the mechanisms by which pathogens evade host immunity and cause disease.

The Vance Lab is one of twelve labs associated with the Division of Immunology and Pathogenesis within the Department of Molecular and Cell Biology at the University of California, Berkeley.


Image: Macrophage infected with Legionella pneumophila. Blue labels extracellular bacterium; red labels intracellular bacteria; green labels LAMP1+ intracellular compartments. L. pneumophila evades LAMP1+ compartments.

Research in the Vance Lab is supported by the generous support of:

HHMI | The National Institutes of Health | Cancer Research Institute | Burroughs Wellcome Fund

Updated: May 2014