Thorner Bibliography


 

 

Publications


2013

Native cysteine residues are dispensable for the structure and function of all five yeast mitotic septins.
de Val N, McMurray MA, Lam LH, Hsiung CC, Bertin A, Nogales E, Thorner J.
Proteins. 2013 Nov;81(11):1964-1979.

A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6.
O'Donnell AF, Huang L, Thorner J, Cyert MS.
J Biol Chem. 2013 Aug 16;288(33):24063-24080.

 

2012

Membrane-protein binding measured with solution-phase plasmonic nanocube sensors.
Wu HJ, Henzie J, Lin WC, Rhodes C, Li Z, Sartorel E, Thorner J, Yang P, Groves JT.
Nat Methods. 2012 Dec;9(12):1189-1191. PubMed Free Text

Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress.
Lee YJ, Jeschke GR, Roelants RM, Thorner J, Turk BE.
Mol Cell Biol. 2012 Nov;32(22):4705-4717. PubMed Free Text

Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae.
Bertin A, McMurray MA, Pierson J, Thai L, McDonald KL, Zehr EA, Garcia G 3rd, Peters P, Thorner J, Nogales E.
Mol Biol Cell. 2012 Feb;23(3):423-432. PubMed Free Text

 

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Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation.
Garcia G 3rd, Bertin A, Li Z, Song Y, McMurray MA, Thorner J, Nogales E.
J Cell Biol. 2011 Dec 12;195(6):993-1004. PubMed Free Text

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.
Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J.
Proc Natl Acad Sci USA. 2011 Nov 29;108(48):19222-19227. PubMed Free Text

Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokenesis.
McMurray MA, Stefan CJ, Wemmer M, Odorizzi G, Emr SD, Thorner J.
Biol Chem. 2011 Aug;392(8-9):699-712. PubMed Free Text

Septin filament formation is essential in budding yeast.
McMurray MA, Bertin A, Garcia G 3rd, Lam L, Nogales E, Thorner J.
Dev Cell. 2011 Apr 19;20(4):540-9. PubMed Free Text

Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast.
Lim S, Strahl T, Thorner J, Ames JB.
J Biol Chem. 2011 Apr 8;286(14):12565-77. PubMed Free Text

 

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Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components.
Patterson JC, Klimenko ES, Thorner J.
Sci Signal. 2010 Oct 19;3(144):ra75. Free Text

Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization.
Bertin A, McMurray MA, Thai L, Garcia G 3rd, Votin V, Grob P, Allyn T, Thorner J, Nogales E.
J Mol Biol. 2010 Dec 10;404(4):711-31. Epub 2010 Oct 15. PubMed Free Text

Dynamic localization of Fus3 mitogen-activated protein kinase is necessary to evoke appropriate responses and avoid cytotoxic effects.
Chen RE, Patterson JC, Goupil LS, Thorner J.
Mol Cell Biol. 2010 Sep;30(17):4293-307. Epub 2010 Jun 28. PubMed Free Text

Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.
Garrenton LS, Stefan CJ, McMurray MA, Emr SD, Thorner J.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11805-10. Epub 2010 Jun 14. PubMed Free Text

Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae.
Chen RE, Thorner J.
Genetics. 2010 Jul;185(3):855-70. Epub 2010 Apr 26 PubMed Free Text

A protein kinase network regulates the function of aminophospholipid flippases.
Roelants FM, Baltz AG, Trott AE, Fereres S, Thorner J.
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):34-9. Epub 2009 Dec 4. PubMed Free Text

 

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Septins: molecular partitioning and the generation of cellular asymmetry.
McMurray MA, Thorner J.
Cell Div. 2009 Aug 26;4:18. PubMed Free Text

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.
Rockwell NC, Wolfger H, Kuchler K, Thorner J.
J Membr Biol. 2009 May;229(1):27-52. Epub 2009 May 19 PubMed Free Text

Reuse, replace, recycle. Specificity in subunit inheritance and assembly of higher-order septin structures during mitotic and meiotic division in budding yeast.
McMurray MA, Thorner J.
Cell Cycle. 2009 Jan 15;8(2):195-203. Review. Free Text

Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.
Garrenton LS, Braunwarth A, Irniger S, Hurt E, Künzler M, Thorner J.

Mol Cell Biol. 2009 Jan;29(2):582-601. Epub 2008 Nov 10. PubMed Free Text

 

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Stress resistance and signal fidelity independent of nuclear MAPK function.
Westfall PJ, Patterson JC, Chen RE, Thorner J.
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12212-7. Epub 2008 Aug 21. PubMed Free Text

Septin stability and recycling during dynamic structural transitions in cell division and development.
McMurray MA, Thorner J.
Curr Biol. 2008 Aug 26;18(16):1203-8. Epub 2008 Aug 14. PubMed Free Text

Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly.
Bertin A, McMurray MA, Grob P, Park SS, Garcia G 3rd, Patanwala I, Ng HL, Alber T, Thorner J, Nogales E.
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8274-9. Epub 2008 Jun 12. PubMed Free Text

The 2008 Novitski Prize. Thomas J. Silhavy.
Thorner JW.
Genetics. 2008 Mar;178(3):1135-6. PubMed Free Text

 

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An adrenaline (and gold?) rush for the GPCR community.
Blumer KJ, Thorner J.
ACS Chem Biol. 2007 Dec 21;2(12):783-6. PubMed Abstract

Membrane-active compounds activate the transcription factors Pdr1 and Pdr3 connecting pleiotropic drug resistance and membrane lipid homeostasis in Saccharomyces cerevisiae.
Schüller C, Mamnun YM, Wolfger H, Rockwell N, Thorner J, Kuchler K.
Mol Biol Cell. 2007 Dec;18(12):4932-44. Epub 2007 Sep 19. PubMed Free Text

Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1).
Strahl T, Huttner IG, Lusin JD, Osawa M, King D, Thorner J, Ames JB.
J Biol Chem. 2007 Oct 19;282(42):30949-59. Epub 2007 Aug 24. Free Text

Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
Chen RE, Thorner J.
Biochim Biophys Acta. 2007 Aug;1773(8):1311-40. Epub 2007 May 22. Review. PubMed Free Text

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae.
Strahl T, Thorner J.
Biochim Biophys Acta. 2007 Mar;1771(3):353-404. Epub 2007 Feb 6. Review. PubMed Free Text

 

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DEP-domain-mediated regulation of GPCR signaling responses.
Ballon DR, Flanary PL, Gladue DP, Konopka JB, Dohlman HG, Thorner J.
Cell. 2006 Sep 22;126(6):1079-93. PubMed Abstract

Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele.
Westfall PJ , Thorner J.
Eukaryot Cell. 2006 Aug;5(8):1215-28. PubMed Free Text

Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.
Asano S, Park JE, Yu LR, Zhou M, Sakchaisri K, Park CJ, Kang YH, Thorner J, Veenstra TD, Lee KS.
J Biol Chem. 2006 Jul 15;20(14):1946-58. PubMed Free Text

Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain.
Garrenton LS, Young SL, Thorner J.
Genes Dev. 2006 Sep 22;126(6):1079-93. PubMed Free Text

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.
Weirich CS, Erzberger JP, Flick JS, Berger JM, Thorner J, Weis K.
Nat Cell Biol. 2006 Jul;8(7):668-76. PubMed Abstract

The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiae.
Truckses DM, Bloomekatz JE, Thorner J.
Mol Cell Biol. 2006 Feb;26(3):912-28. PubMed Free Text

"Signal Transduction" in Landmark Papers in Yeast Biology
Linder P, Shore D, Hall MN, Eds.
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 193-210.

 

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Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus.
Strahl T, Hama H, DeWald DB, Thorner J.
J Cell Biol. 2005 Dec 19;171(6):967-979. PubMed Free Text

Systems biology approaches in cell signaling research.
Chen RE, Thorner J.
Genome Biol. 2005 6(10):235. Review. PubMed Free Text
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Some assembly required: yeast septins provide the instruction manual.
Versele M , Thorner J.
Trends Cell Biol. 2005 Aug;15(8):414-424. Review. PubMed Free Text

Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast.
Rodriguez-Escudero I, Roelants FM, Thorner J, Nombela C, Molina M, Cid VJ.
Biochem J. 2005 Sep 1;390(Pt 2):613-623. PubMed Free Text

 

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When the stress of your environment makes you go HOG wild.
Westfall PJ, Ballon DR, Thorner J.
Science. 2004 Nov 26; 306(5701):1511-1512. Pub Med Abstract

Jekyll and Hyde in the microbial world.
Truckses DM , Thorner J.
Science. 2004 Nov 26;306(5701):1509-1511. PubMed Abstract

"Pheromone receptors (Yeast)" in Encyclopedia of Biological Chemistry.
Konopka JB, Thorner JW; Lennarz WJ, Lane MD, eds.
Elsevier Science, Inc., Oxford, UK, Vol. 3, pp 256-261.

Differential roles of PDK1- annd PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9.
Roelants FM, Torrance PD , Thorner J.
Microbiology. 2004 Oct;150(Pt 10):3289-3304. Free Text

Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae.
Versele M, Gullbrand B, Shulewitz MJ, Cid VJ, Bahmanyar S, Chen RE, Barth P, Alber T , Thorner J.
Mol Biol Cell. 2004 Oct15(10):4568-4583. PubMed Free Text

The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing.
Rockwell NC, Thorner JW.
Trends Biochem Sci. 2004 Feb;29(2):80-87. Review. PubMed Abstract

Coupling morphogenesis to mitotic entry.
Sakchaisri K, Asano S, Yu LR, Shulewitz MJ, Park CJ, Park JE, Cho YW, Veenstra TD, Thorner J, Lee KS.
Proc Natl Acad Sci USA. 2004 Mar 23;101(12):4124-4129. PubMed Free Text

Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4.
Versele M , Thorner J.
J Cell BIol. 2004 Mar 1;164(5):701-715. PubMed Free Text

Roles of phosphoinsitides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.
Rudge SA, Sciorra VA, Iwamoto M, Zhou C, Strahl T, Morris AJ, Thorner J, Engebrecht J.
Mol Biol Cell. 2004 Jan;15(1):207-218. PubMed Free Text

 

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Conservation of regulatory function in calcium-binding proteins: human frequenin (neuronal calcium sensor-1) associates productively with yeast phosphatidylinositol 4-kinase isoform, Pik1.
Strahl T, Grafelmann B, Dannenberg J, Thorner J, Pongs O..
J Biol Chem. 2003 Dec 5;1278(49):49589-49599. Free Text

Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex.
Wang Y, Ge Q, Houston D, Thorner J, Errede B, Dohlman HG.
J Biol Chem. 2003 Jun 20;278(25):22284-22289. Free Text

Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1.
Huttner IG, Strahl T, Osawa M, King DS, Ames JB, Thorner J.
J Biol Chem. 2003 Feb 14;278(7):4862-4874. Free Text

 

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Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity.
Roelants FM, Torrance PD, Bezman N, Thorner J.
Mol Biol Cell. 2002 Sep;13(9):3005-3028. Free PubMed Text

Orchestrating the cell cycle in yeast: sequential localization of key mitotic regulators at the spindle pole and the bud neck.
Cid VJ, Jimenez J, Molina M, Sanchez M, Nombela C, Thorner JW.
Microbiology. 2002 Sep;148(Pt9):2647-2659. Review. Free Text

Direct and novel regulation of cAMP-dependent protein kinase by Mck1p, a yeast glycogen synthase kinase-3.
Rayner TF, Gray JV, Thorner JW.
J Biol Chem. 2002 May 10;277(19):16814-16822. Free Text

Life in the Atomic Age: Cell Biology by Thomas D. Pollard and William C. Earnshaw.
Thorner J.
Nat Cell Biol. 2002 4:E286. Book Review.

 

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Thorner, J.

Greasing the Wheels of Secretory Transport
Nature Cell Biology 3(8):E196-E198 (August) Abstract

 

Cid, V.J., Shulewitz, M.J., McDonald, K.L. and Thorner, J.

Dynamic Localization of the Swe1 Regulator Hs17 During the Saccharomyces cerevisiae Cell Cycle
Molecular Biology of the Cell 12:1645-1669 (June) Abstract

 

Adamkewicz, J.I., Hansen, K.E., Prud'homme, W.A., Davis, J.L. and Thorner, J.

High Affinity Interaction of Yeast Transcriptional Regulator, Mot1, with TATA Box-Binding
Protein (TBP)
Journal of Biological Chemistry 276(15):11883-11894 (April 13) Abstract

 

Bardwell, A.J., Flatauer, L.J., Matsukuma, K., Thorner, J. and Bardwell, L.

A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission
Journal of Biological Chemistry 276:10374-10386 (March 30) Abstract

 

Kunzler, M., Trueheart, J., Sette, C., Hurt, E. and Thorner, J.

Mutations in the YRB1 Gene Encoding Yeast Ran-Binding-Protein-1 That Impair Nucleocytoplasmic Transport and Suppress Yeast Mating Defects
Genetics 157:1089-1105 (March) Abstract

 

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Sette, C., Inouye, C.J., Stroschein, S.L., Iaquinta, P.J. and Thorner, J.

Mutational Analysis Suggests That Activation of the Yeast Pheromone Response Mitogen-activated Protein Kinase Pathway Involves Conformational Changes in the Ste5 Scaffold Protein
Molecular Biology of the Cell 11:4033-4049 (Nov) Abstract

 

Ames, J.B., Hendricks, K.B., Strahl, T., Huttner, I.G., Hamasaki, N. and Thorner, J.

Structure and Calcium-Binding Properties of Frq1, a Novel Calcium Sensor in the Yeast Saccharomyces cerevisiae
Biochemistry 39(40):12149-12161 Abstract

 

Adamkewicz, J.I., Mueller, C.G.F., Hansen, K.E., Prud'homme, W.A. and Thorner, J.

Purification and Enzymic Properties of Mot1 ATPase, a Regulator of Basal Transcription in the Yeast Saccharomyces cerevisiae
Journal of Biological Chemistry 275:21158-21168 (July 14) Abstract

 

Petersen, C., Orem, N., Trueheart, J., Thorner, J., and Macara, I.G.

Random Mutagenesis and Functional Analysis of the Ran-binding Protein, RanBP1
Journal of Biological Chemistry 275:4081-4091 (February 11) Abstract

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Hama, H., Schnieders, E.A., Thorner, J., Takemoto, J.Y. and DeWald, D.B.

Direct Involvement of Phosphatidylinositol 4-Phosphate in Secretion in the Yeast Saccharomyces cerevisiae
Journal of Biological Chemistry 274:34294-34300 (Nov 26) Abstract

 

Shulewitz, M.J., Inouye, C.J.and Thorner, J.

Hs17 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae
Molecular and Cellular Biology 19:7123-7137 (October 1999) Abstract

 

Hendricks, K.B., Wang, B.Q., Schnieders, E.A. and Thorner, J.

Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase
Nature Cell Biology 1:234-241 (August 1999) Abstract

 

Casamayor, A., Torrance, P.D., Kobayashi, T., Thorner, J. and Alessi, D.R.

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast
Current Biology 9:186-197 (Feb 1999) Abstract

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Bardwell, L., Cook J.G., Zhu-Shimoni, J., Voora, D. and Thorner, J.

Differential regulation of transcription: repression by unactivated
mitogen-activated protein kinase kss1 requires the dig1 and dig2
proteins.
Proc. Natl. Acad. Sci. U.S.A. 95:15400-15405 (Dec 1998) Abstract

Bardwell, L., Cook, J.G., Voora, D., Baggott, D.M. and Thorner, J.

Repression of yeast Ste12 transcription factor by direct binding of
unphosphorylated Kss1MAPK and its regulation by the Ste7 MEK.
Genes and Development 12: 2887-2898 (Sept. 15, 1998) Abstract

Stolz, L.E., Huynh, C.V., Thorner, J. and York, J.D.

Identification and Characterization of an Essential Family of Inositol
Polyphosphate 5-Phosphatases (INP51, INP52 and INP53 Gene
Products) in the Yeast Saccharomyces cerevisiae.
Genetics 148:1715-1729 (Apr 1998) Abstract
 

Flick, J.S. and Thorner, J.

An Essential Function of a Phosphoinositide-Specific Phospholipase C
Is Relieved by Inhibition of a Cyclin-Dependent Protein Kinase in the
Yeast Saccharomyces cerevisiae.
Genetics 148:33-46 (Jan 1998) Abstract


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Cook, J.G., Bardwell, L., Thorner, J.
Inhibitory and Activating Functions for MAPK Kss1 in the
S. cerevisiae filamentous-growth signalling pathway.
Nature 390: 85-88 (November 6, 1997) Abstract
 

Inouye, C., Dhillon, N., Thorner, J.

Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for
Yeast Pheromone Signaling.
Science 278: 103-106 (October 3, 1997) Abstract
 

Inouye C., Dhillon, N., Durfee, T., Zambryski, P.C., Thorner, J.

Mutational Analysis of STE5 in the Yeast Saccharomyces cerevisiae:
Application of a Differential Interaction Trap Assay for Examining
Protein-Protein Interactions.
Genetics 147: 479-492 (October 1997) Abstract
 

Brazill DT; Thorner J; Martin GS.

Mck1, a member of the glycogen synthase kinase 3 family of protein kinases, is a negative regulator of pyruvate kinase in the yeast Saccharomyces cerevisiae.
J Bacteriol.179(13), 4415-4418 (1997) Abstract
 

Wilson LK; Dhillon N; Thorner J; Martin GS.

Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3.J. Biol. Chem. 272(20), 12961-7 (1997) Abstract


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Melcher ML; Thorner J.
Identification and characterization of the CLK1 gene product, a novel CaM kinase-like protein kinase from the yeast Saccharomyces cerevisiae.
J. Biol. Chem. 271(47), 29958-68 (1996) Abstract
 

Cook JG; Bardwell L; Kron SJ; Thorner J.

Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae.
Genes Dev. 10(22), 2831-48 (1996) Abstract
 

Broach JR; Thorner J.

High-throughput screening for drug discovery.
Nature 384(6604 Suppl), 14-6 (1996) Abstract
 

Bardwell L; Thorner J.

A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs.
Trends Biochem. Sci. 21(10), 373-4 (1996) Abstract
 

Dohlman HG; Song J; Ma D; Courchesne WE; Thorner J.

Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).
Mol. Cell. Biol. 16(9), 5194-209 (1996) Abstract
 

Bardwell L; Cook JG; Chang EC; Cairns BR; Thorner J.

Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.
Mol. Cell. Biol. 16, 3637-3650 (1996) Abstract
 

Swartzman EE; Viswanathan MN; Thorner J.

The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae.
J. Cell Biol. 132, 549-563 (1996) Abstract



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Jiang W; Lim MY; Yoon HJ; Thorner J; Martin GS; Carbon J.
Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5.
Mol Gen Genet 246, 360-366 (1995) Abstract
 

Ma D; Cook JG; Thorner J.

Phosphorylation and localization of Kss1, a MAP kinase of the Saccharomyces cerevisiae pheromone response pathway.
Mol Biol Cell 6, 889-909 (1995) Abstract
 

Wilson LK; Benton BM; Zhou S; Thorner J; Martin GS.

The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1.
J Biol Chem 270, 25185-25193 (1995) Abstract
 

Harris E; Yaswen P; Thorner J.

Gain-of-function mutations in a human calmodulin-like protein identify residues critical for calmodulin action in yeast.
Mol Gen Genet 247, 137-147 (1995) Abstract



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Harris E; Watterson DM; Thorner J.
Functional consequences in yeast of single-residue alterations in a consensus calmodulin.
J Cell Sci 107, 3235-3249 (1994) Abstract
 

Bardwell L; Cook JG; Inouye CJ; Thorner J.

Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae.
Dev Biol 166, 363-379 (1994) Abstract
 

Salama SR; Hendricks KB; Thorner J.

G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover.
Mol Cell Biol 14, 7953-7966 (1994) Abstract
 

Benton BM; Zang JH; Thorner J.

A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.
J Cell Biol 127, 623-639 (1994) Abstract
 

Auble DT; Hansen KE; Mueller CG; Lane WS; Thorner J; Hahn S.

Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism.
Genes Dev. 8, 1920-34 (1994) Abstract
 

Florio M; Wilson LK; Trager JB; Thorner J; Martin GS.

Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.
Mol Biol Cell 5, 283-296 (1994) Abstract
 

Perler FB; Davis EO; Dean GE; Gimble FS; Jack WE; Neff N; Noren CJ; Thorner J; Belfort M.

Protein splicing elements: inteins and exteins--a definition of terms and recommended nomenclature.
Nucleic Acids Res 22, 1125-7 (1994) Abstract
 

Hasson MS; Blinder D; Thorner J; Jenness DD.

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.
Mol Cell Biol 14, 1054-65 (1994) Abstract



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Flanagan CA; Schnieders EA; Emerick AW; Kunisawa R; Admon A; Thorner J.
Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability.
Science 262, 1444-8 (1993) Abstract
 

Dohlman HG; Goldsmith P; Spiegel AM; Thorner J.

Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae.
Proc Natl Acad Sci U S A 90, 9688-92 (1993) Abstract
 

Gimble FS; Thorner J.

Purification and characterization of VDE, a site-specific endonuclease from the yeast Saccharomyces cerevisiae.
J Biol Chem 268, 21844-53 (1993) Abstract
 

Lim MY; Dailey D; Martin GS; Thorner J.

Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine.
J Biol Chem 268, 21155-64 (1993) Abstract
 

Flick JS; Thorner J.

Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.
Mol Cell Biol 13, 5861-76 (1993) Abstract
 

Kuchler K; Dohlman HG; Thorner J.

The a-factor transporter (STE6 gene product) and cell polarity in the yeast Saccharomyces cerevisiae.
J Cell Biol 120, 1203-15 (1993) Abstract



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Kuchler K; Goransson HM; Viswanathan MN; Thorner J.
Dedicated transporters for peptide export and intercompartmental traffic in the yeast Saccharomyces cerevisiae.
Cold Spring Harb Symp Quant Biol 57, 579-92 (1992) (no abstract available)
 

Bremer MC; Gimble FS; Thorner J; Smith CL.

VDE endonuclease cleaves Saccharomyces cerevisiae genomic DNA at a single site: physical mapping of the VMA1 gene.
Nucleic Acids Res 20, 5484 (1992) (no abstract available)
 

Flanagan CA; Thorner J.

Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae.
J Biol Chem 267, 24117-25 (1992) Abstract
 

Kuchler K; Thorner J.

Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocators.
Endocr Rev 13, 499-514 (1992) Abstract
 

Cyert MS; Thorner J.

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.
Mol Cell Biol 12, 3460-9 (1992) Abstract
 

Gimble FS; Thorner J.

Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae.
Nature 357, 301-6 (1992) Abstract
 

Kuchler K; Thorner J.

Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae.
Proc Natl Acad Sci U S A 89, 2302-6 (1992) Abstract
 

Davis JL; Kunisawa R; Thorner J.

A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae.
Mol Cell Biol 12, 1879-92 (1992) Abstract



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Fields FO; Thorner J.
Genetic suppression analysis of the function of a protein kinase C (PKC1 gene product) in Saccharomyces cerevisiae cell cycle progression: the SKCd mutations.
Cold Spring Harb Symp Quant Biol 56, 51-60 (1991) (no abstract available)
 

Dohlman HG; Thorner J; Caron MG; Lefkowitz RJ.

Model systems for the study of seven-transmembrane-segment receptors.
Annu. Rev. Biochem. 60, 653-688 (1991) (no abstract available)
 

Cyert MS; Kunisawa R; Kaim D; Thorner J.

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase [published erratum appears in Proc Natl Acad Sci U S A 1992 May 1;89(9):4220]
Proc Natl Acad Sci U S A 88, 7376-80 (1991) Abstract
 

Pausch MH; Kaim D; Kunisawa R; Admon A; Thorner J.

Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote.
EMBO J 10, 1511-22 (1991) Abstract



1990uparrow.gif - 1.0 K


Bresnahan PA; Leduc R; Thomas L; Thorner J; Gibson HL; Brake AJ; Barr PJ; Thomas G.
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.
J Cell Biol 111, 2851-9 (1990) Abstract
 

Kuchler K; Thorner J.

Membrane translocation of proteins without hydrophobic signal peptides.
Curr Opin Cell Biol 2, 617-24 (1990) (no abstract available)
 

Dailey D; Schieven GL; Lim MY; Marquardt H; Gilmore T; Thorner J; Martin GS.

Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity [published erratum appears in Mol Cell Biol 1991 Apr;11(4):2333]
Mol Cell Biol 10, 6244-56 (1990) Abstract
 

Marr RS; Blair LC; Thorner J.

Saccharomyces cerevisiae STE14 gene is required for COOH-terminal methylation of a-factor mating pheromone.
J Biol Chem 265, 20057-60 (1990) Abstract
 

King K; Dohlman HG; Thorner J; Caron MG; Lefkowitz RJ.

Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit [published erratum appears in Science 1991 Jan 11;251(4990):144]
Science 250, 121-3 (1990) Abstract
 

Levin DE; Fields FO; Kunisawa R; Bishop JM; Thorner J.

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle.
Cell 62, 213-24 (1990) Abstract
 

Blumer KJ; Thorner J.

Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling.
Proc Natl Acad Sci U S A 87, 4363-7 (1990) Abstract



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Yu L; Blumer KJ; Davidson N; Lester HA; Thorner J.
Functional expression of the yeast alpha-factor receptor in Xenopus oocytes.
J Biol Chem 264, 20847-50 (1989) Abstract
 

Kuchler K; Sterne RE; Thorner J.

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.
EMBO J 8, 3973-84 (1989) Abstract
 

Fuller RS; Brake AJ; Thorner J.

Intracellular targeting and structural conservation of a prohormone-processing endoprotease.
Science 246, 482-6 (1989) Abstract
 

Davis TN; Thorner J.

Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable.
Proc Natl Acad Sci U S A 86, 7909-13 (1989) Abstract
 

Courchesne WE; Kunisawa R; Thorner J.

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae.
Cell 58, 1107-19 (1989) Abstract
 

Schafer WR; Kim R; Sterne R; Thorner J; Kim SH; Rine J.

Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans.
Science 245, 379-85 (1989) Abstract
 

Cyert MS; Thorner J.

Putting it on and taking it off: phosphoprotein phosphatase involvement in cell cycle regulation.
Cell 57, 891-3 (1989) (no abstract available)
 

Flessel MC; Brake AJ; Thorner J.

The MF alpha 1 gene of Saccharomyces cerevisiae: genetic mapping and mutational analysis of promoter elements.
Genetics 121, 223-36 (1989) Abstract
 

Fuller RS; Brake A; Thorner J.

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
Proc Natl Acad Sci U S A 86, 1434-8 (1989) Abstract




References and abstracts were obtained from NCBI.

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