Selected Recent Review Articles

 

Geier, J.K. and Schlissel, M.S. (2006). Pre-BCR signals and the control of Ig gene rearrangements. Semin Immunol 18, 31-9.

 

Schlissel, M.S. and Kuo, T.C. (2006). AID for innate immunity to retroviral transformation. Immunity 24, 671-2.

 

Schlissel, M.S., Kaffer, C.R. and Curry, J.D. (2006). Leukemia and lymphoma: a cost of doing business for adaptive immunity. Genes Dev 20, 1539-44.

 

Amin, R. H., and Schlissel, M. S. (2005). NF-kappa B comes home. Immunity 22, 401-402.

 

Schlissel, M. (2004). The spreading influence of chromatin modification. Nat Genet 36, 438-40.

 

Schlissel, M. S. (2003). Regulating antigen-receptor gene assembly. Nat Rev Immunol 3, 890-899.

 

Schlissel, M. (2003). How pre-B cells know when they have it right. Nat Immunol 4, 817-819.

 

Robey, E., and Schlissel, M. (2003). Lymphocyte development. Curr Opin Immunol 15, 155-157.

 

Schlissel, M. (2002). Allelic exclusion of immunoglobulin gene rearrangement and expression: why and how? Semin Immunol 14, 207.

 

Schlissel, M. S. (2002). Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination? Cell 109, 1-4.

Selected Research Articles

Amin RH, Cado D, Nolla H, Huang D, Shinton SA, Zhou Y, Hardy RR, Schlissel MS (2008) Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development. Proc Natl Acad Sci U S A.102, 522-527.

 

Amin, R. H., and Schlissel, M. S. (2008). Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat Immunol 9, 613-622.

 

Bates, J. G., D. Cado, H. Nolla, and M. S. Schlissel. (2007). Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination. J Exp Med 204:3247-3256.

 

Constantinescu, A., and Schlissel, M. S. (1997). Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J Exp Med 185, 609-620.

 

Curry JD, Schlissel MS (2008) RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination. Nucleic Acids Res. 36 (18), 5750-62.

 

Curry, J.D., Schulz, D., Guidos, C.J., Danska, J.S., Nutter, L., Nussenzweig, A. and Schlissel, M.S. (2007). Chromosomal reinsertion of broken RSS ends during T cell development. J Exp Med 204, 2293-303.

 

Curry, J.D., Geier, J.K. and Schlissel, M.S. (2005). Single-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsis. Nat Immunol 6, 1272-9.

 

Curry, J. D., Li, L., and Schlissel, M. S. (2005). Quantification of Jkappa signal end breaks in developing B cells by blunt-end linker ligation and qPCR. J Immunol Methods 296, 19-30.

 

Dillon, S. R., Constantinescu, A., and Schlissel, M. S. (2001). Annexin V binds to positively selected B cells. J Immunol 166, 58-71.

 

Dillon, S. R., Mancini, M., Rosen, A., and Schlissel, M. S. (2000). Annexin V binds to viable B cells and co-localizes with a marker of lipid rafts upon B cell receptor activation. J Immunol 164, 1322-1332.

 

Dillon, S. R., and Schlissel, M. S. (2002). Partial restoration of B cell development in Jak-3(-/-) mice achieved by co-expression of IgH and Em-myc transgenes. Int Immunol 14, 893-904.

 

Golding, A., Chandler, S., Ballestar, E., Wolffe, A. P., and Schlissel, M. S. (1999). Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase. Embo J 18, 3712-3723.

 

Goldmit, M., Schlissel, M., Cedar, H., and Bergman, Y. (2002). Differential accessibility at the kappa chain locus plays a role in allelic exclusion. Embo J 21, 5255-5261.

 

Hempel, W. M., Stanhope-Baker, P., Mathieu, N., Huang, F., Schlissel, M. S., and Ferrier, P. (1998). Enhancer control of V(D)J recombination at the TCRb locus: differential effects on DNA cleavage and joining. Genes Dev 12, 2305-2317.

 

Hewitt, S. L., Farmer, D., Marszalek, K., Cadera, E., Liang, H. E., Xu, Y., Schlissel, M. S., and Skok, J. A. (2008). Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells. Nat Immunol 9, 396-404.

 

Hsu, L. Y., Lauring, J., Liang, H. E., Greenbaum, S., Cado, D., Zhuang, Y., and Schlissel, M. S. (2003). A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity 19, 105-117.

 

Hsu, L. Y., H. E. Liang, K. Johnson, C. Kang and M. S. Schlissel (2004). Pax5 Activates Immunoglobulin Heavy Chain V to DJ Rearrangement in Transgenic Thymocytes. J Exp Med 199, 825-30.

 

Huang, F., Kitaura, Y., Jang, I., Naramura, M., Kole, H.H., Liu, L., Qin, H., Schlissel, M.S. and Gu, H. (2006). Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. Immunity 25, 571-81.

 

Kitaura, Y., Jang, I.K., Wang, Y., Han, Y.C., Inazu, T., Cadera, E.J., Schlissel, M., Hardy, R.R. and Gu, H. (2007). Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 26, 567-78.

 

Lauring, J., and Schlissel, M. S. (1999). Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines. Mol Cell Biol 19, 2601-2612.

 

Lazorchak, A.S., Schlissel, M.S. and Zhuang, Y. (2006). E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol Cell Biol 26, 810-21.

 

Liang, H. E., Hsu, L. Y., Cado, D., Cowell, L. G., Kelsoe, G., and Schlissel, M. S. (2002). The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. Immunity 17, 639-651.

 

Liang, H. E., L. Y. Hsu, D. Cado and M. S. Schlissel (2004). Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression. Cell 118, 19-29.

 

Morrow, T. A., Muljo, S. A., Zhang, J., Hardwick, J. M., and Schlissel, M. S. (1999). Pro-B-cell-specific transcription and pro-apoptotic function of protein kinase. Mol Cell Biol 19, 5608-5618.

 

Muljo, S. A., and Schlissel, M. S. (2002). The variable, C(H)1, C(H)2 and C(H)3 domains of Ig heavy chain are dispensable for pre-BCR function in transgenic mice. Int Immunol 14, 577-584.

 

Muljo, S. A., and Schlissel, M. S. (2003). A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat Immunol 4, 31-37.

 

Schlissel, M., Constantinescu, A., Morrow, T., Baxter, M., and Peng, A. (1993). Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev 7, 2520-2532.

 

Schlissel, M. S. (1998). Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination. Mol Cell Biol 18, 2029-2037.

 

Schlissel, M. S., Durum, S. D., and Muegge, K. (2000). The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase. J Exp Med 191, 1045-1050.

 

Shaffer, A. L., Peng, A., and Schlissel, M. S. (1997). In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activation. Immunity 6, 131-143.

 

Shaffer, A. L., and Schlissel, M. S. (1997). A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. J Immunol 159, 1265-1275.

 

Sheehy, A. M., and Schlissel, M. S. (1999). Overexpression of RelA causes G1 arrest and apoptosis in a pro-B cell line. J Biol Chem 274, 8708-8716.

 

Stanhope-Baker, P., Hudson, K. M., Shaffer, A. L., Constantinescu, A., and Schlissel, M. S. (1996). Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85, 887-897.

 

Wang, Q. F., Lauring, J., and Schlissel, M. S. (2000). c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells. Mol Cell Biol 20, 9203-9211.