Selected Publications

The human THAP9 gene encodes an active P-element DNA transposase.
Majumdar S., Singh A., Rio D.C. (2013). Science. 339, 446-448.

Two new and distinct nuclear roles for Drosophila Argonaute-2: Alternative pre-mRNA splicing and transcriptional repression.
Taliaferro, J.M., Aspden, J.L, Bradley, T., Marwha, D., Blanchette, M., and Rio, D.C. (2013). Genes and Development, 27, 378-389.

Evolution of a tissue-specific splicing network.
Taliaferro, J.M., Alvarez, N., Green, R.E., Blanchette, M., and Rio, D.C. (2011) Genes and Development. 25(6), 608-620.

THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves.
Sabogal, A., Lyubimov, A.Y., Corn J.E., Berger, J.M. and Rio, D.C. (2010). Nat. Struct. Molec. Biol. 17, 117-124.

Genome-wide analysis of alternative pre-mRNA splicing and RNA binding specificities of the Drosophila hnRNP A/B family members.
Blanchette, M., Green, R.E., MacArthur, S., Brooks, A.N., Brenner, S.E., Eisen, M.B., and Rio D.C. (2009) Mol. Cell 33, 438-449

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome.
Sharma, S., Kohlstaedt, L.A., Damianov, A., Rio, D.C. and Black, D.L. (2008) Nat. Struct. Mol. Biol. 15, 183-191.

Analysis of P element transposase protein-DNA interactions during the early stages of transposition.
Tang, M, Cecconi, C., Bustamante, C. and Rio, D.C. (2007) J. Biol. Chem. 282, 29002-29012.

A regulator of mutually exclusive splicing fidelity in Dscam.
Olson, S., Blanchette, M., Park, J., Saava, Y., Yeo, G.W., Yeakley, J.M., Rio, D.C. and Graveley, B.R. (2007) Nat. Struct. Mol. Biol. 14, 1134-1140.

Guanosine triphosphate acts as a cofactor to promote assembly of initial P element transposase-DNA synaptic complexes.
Tang, M, Cecconi, C., Kim, H., Bustamante, C. and Rio, D.C. (2005) Genes Dev. 19, 1422-1425.

Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila.
Blanchette, M., Green, R.E., Brenner, S.E. and Rio, D.C. (2005) Genes Dev. 19, 1306-1314.