Our Research

The general interest of our laboratory is nucleic acid transactions, specifically, the mechanisms of DNA recombination used to mobilize transposable DNA elements (a process called transposition) and how RNA binding proteins control patterns of alternative pre-mRNA splicing. About half the human genome is composed of transposons; transposable DNA insertions have been linked to human disease gene mutations and chromosomal rearrangements and are thought to be important for genome and organismal evolution.

Publications

Ghanim, G., Rio, D.C. and Karam Teixeira, Felipe. (2020). Mechanism and regulation of P element transposition. Open Biology, Open Biol. 2020 Dec;10(12):200244. doi: 10.1098/rsob.200244. Epub 2020 Dec 23. PMID: 33352068

Ghanim, G., Rio, D.C. and Karam Teixeira, Felipe. (2020). Mechanism and regulation of P element transposition. Open Biology, Open Biol. 2020 Dec;10(12):200244. doi: 10.1098/rsob.200244. Epub 2020 Dec 23. PMID: 33352068
Selected Publications

Wang, Q., Conlon, E., Gao, J., Manley, J.L. and Rio, D.C. (2020). Widespread intron retention impairs protein homeostasis in C9ORF72 ALS brains. Genome Research, Genome Res. 2020 Dec;30(12):1705-1715. doi: 10.1101/gr.265298.120. Epub 2020 Oct 14. PMID: 33055097

Wang, Q., Conlon, E., Gao, J., Manley, J.L. and Rio, D.C. (2020). Widespread intron retention impairs protein homeostasis in C9ORF72 ALS brains. Genome Research, Genome Res. 2020 Dec;30(12):1705-1715. doi: 10.1101/gr.265298.120. Epub 2020 Oct 14. PMID: 33055097
Selected Publications

Ghanim, G., Kellogg, E., Nogales, E. and Rio, D.C. (2019). Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts. Nature Struct. Mol. Biol. 26(11):1013-1022. doi: 10.1038/s41594-019-0319-6. PMID: 31659330; PMCID: PMC6948148

Ghanim, G., Kellogg, E., Nogales, E. and Rio, D.C. (2019). Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts. Nature Struct. Mol. Biol. 26(11):1013-1022. doi: 10.1038/s41594-019-0319-6. PMID: 31659330; PMCID: PMC6948148
Selected Publications

New and views: Rice, P.A. (2019). Structure of the P element transpososome reveals new twists on the DD(E/D) theme. Nat Struct Mol Biol. 2019 Nov;26(11):989-990.

New and views: Rice, P.A. (2019). Structure of the P element transpososome reveals new twists on the DD(E/D) theme. Nat Struct Mol Biol. 2019 Nov;26(11):989-990.
Selected Publications