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Bahjat KS, Liu W, Lemmens EE, Schoenberger SP, Portnoy DA, Dubensky TW Jr, Brockstedt DG. (2006). Cytosolic entry controls CD8+-T-cell potency during bacterial infection. Infect Immun. 74(11):6387-97.

Bakardjiev, A.I., J.A. Theriot and D.A. Portnoy. (2006). Listeria monocytogenes traffics from the maternal organs to the placenta and back. PloS Pathogens 2:623-631.

Schnupf, P., D.A. Portnoy and A.L. Decatur. (2006). Phosphorylation, ubiquitination, and degradation of Listerolysin O in mammalian cells: role of the PEST-like sequence. Cell. Microbiol. 8:353-364.

Tabeta, K., et. al. (2006). The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. Feb 7: 156-164.

Cheng LW, Viala JP, Stuurman N, Wiedemann U, Vale RD, Portnoy DA. (2005). Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Proc Natl Acad Sci U S A. Sep 20;102(38):13646-51.

Brockstedt DG, Bahjat KS, Giedlin MA, Liu W, Leong M, Luckett W, Gao Y, Schnupf P, Kapadia D, Castro G, Lim JY, Sampson-Johannes A, Herskovits AA, Stassinopoulos A, Bouwer HG, Hearst JE, Portnoy DA, Cook DN, Dubensky TW Jr. (2005). Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity. Nat Med. Aug;11(8):853-60.

Bakardjiev AI, Stacy BA, Portnoy DA. (2005). Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection. J Infect Dis. Jun 1;191(11):1889-97.

Portnoy DA. (2005). Manipulation of innate immunity by bacterial pathogens. Curr Opin Immunol. Feb;17(1):25-8. Review.

Brockstedt D. G, M. A. Giedlin, M. L., Leong, K. S. Bahjat, Y. Gao, W. Luckett, W. Liu, D. N. Cook, D. A. Portnoy, and T. W. Dubensky Jr. (2004). Listeria-based cancer vaccines that segregate immunogenicity from toxicity. Proc. Natl. Acad. Sci. USA., Sep 21;101(38):13832-7.

Auerbuch, V., D. G. Brockstedt, N. Meyer-Morse, M. O'Riordan, and D. A. Portnoy. (2004). Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. J. Exp. Med. 200(4):527-533.

McCaffrey, R., P. Fawcett, M. O'Riordan, K.D. Lee, E. A. Havell, P. O. Brown, and D. A. Portnoy. (2004). A specific gene expression program triggered by Gram-positive bacteria in the cytosol. Proc. Natl. Acad. Sci., 101(31):11386-91.

Bakardjiev, A. I., B. A. Stacy, S. J. Fisher, and D. A. Portnoy. (2004). Listeriosis in pregnant guinea pigs: A model of vertical transmission. Infect. Immun. 72:489-497.

Glomski, I., A. L. Decatur, and D. A. Portnoy. (2003) Listeria monocytogenes mutants that fail to compartmentalize LLO activity are cytotoxic, avirulent, and unable to evade host extracellular defenses. Infect. Immun. 71:6754-6765.

Lenz, L. L., S. Mohammadi, A. Geissler, and D. A. Portnoy. (2003). SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. Proc. Natl. Acad. Sci. 100:12432-12437.

O'Riordan, M., M. A. Moors, and D. A. Portnoy. (2003) Utilization of host-derived lipoic acid required for Listeria intracellular growth and virulence. Science. 302:462-464.

Cheng, L. W. and D. A. Portnoy. (2003). Drosophila S2 cells: an alternate infection model for Listeria monocytogenes. Cell Microbiol. 5:875-885.

Auerbuch, V., J. J. Loureiro, F. B. Gertler, J. A. Theriot, and D. A. Portnoy. (2003). Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of actin-based motility. Mol Microbiol. 49:1361-1375.

O'Riordan, M., C. H. Yi, R. Gonzalez, K.D. Lee, and D. A. Portnoy. (2002). Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc. Natl. Acad. Sci. 99:13861-13866.

Dancz, C. E., A. Haraga, D. A. Portnoy, and D. E. Higgins. (2002). Inducible control of virulencegene expression in Listeria monocytogenes: Temporal requirement of listeriolysin O during intracellular infection. J Bacteriol. 184(21):5935-45.

Lauer, P., M.Y.N. Chow, M. J. Loessner, D. A. Portnoy, and R. Calendar. (2002). Construction, characterization and use of two Listeria monocytogenes site-specific integration vectors. J. Bacteriol. 184:4177-4186.

Lenz, L.L. and D.A. Portnoy. (2002). Identification of a second Listeria secA gene that promotes protein secretion and is associated with the rough phenotype. Mol. Microbiol. 45:1043-1056.

Auerbuch, V. and D.A. Portnoy. (2002). Microbial pathogenesis and the eukaryotic cytoskeleton at the American Society for Cell Biology annual meeting. Cell Microbiol. 4(3):187-90.

Glomski, I.J., M.M. Gedde, A.W. Tsang, J.A. Swanson, and D.A. Portnoy. (2002). The L. monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. J Cell Biol, 156:1029-1038.

Lauer, P., J.A. Theriot, J. Skoble, M.D. Welch, and D.A. Portnoy. (2001). Systematic mutational analysis of the amino terminal domain of the Listeria monocytogenes ActA protein reveals novel functions in actin-based motility. Mol Microbiology, 42:1163-1177.

Skoble, J., E. Goley, V. Auerbuch, M.D. Welch, and D.A. Portnoy. (2001). Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation and Listeria monocytogenes motility. J Cell Biol. 155:89-100.

Auerbuch, V., L. Lenz, and D.A. Portnoy. (2001). Development of a competitive index assay to evaluate the virulence of Listeria monocytogenes ActA mutants during primary and secondary infection of mice. Infect Immun. 69:5953-5957.

Decatur, A.L. and D.A. Portnoy. (2000). A PEST-like sequence in listerolysin O essential for Listeria monocytogenes pathogenicity. Science, 290:992-995.

Skoble, J., D.A. Portnoy, and M.D. Welch. (2000). Three regions within ActA that promote Arp2/3 complex-mediated actin nucleation and L. monocytogenes motility. J. Cell Biol. 150:527-537.

Gedde, M. M., Higgins, D., Tilney, L.G., and Portnoy, D. A. (2000). Role of Listeriolysin O in Cell-To-Cell Spread of Listeria monocytogenes. Infect Immun 68:999-1003.

Moors, M. A., Auerbuch, V., and Portnoy, D. A. (1999). Stability of the Listeria monocytogenes ActA protein in mammalian cells is regulated by the N-end rule pathway. Cellular Microbiology, 1:249-258.

Higgins, D.E. , Shastri, N., and Portnoy, D. A. (1999). Delivery of protein to the cytosol of macrophages using Escherichia coli K-12. Mol Microbiology 31:1631-1641.

Moors, M. A., Levitt, B., Youngman, P., and Portnoy, D. A. (1999). Expression of listeriolysin O and ActA by intracellular and extracellular Listeria monocytogenes. Infect Immun 67:131-9.

Higgins, D. E., and Portnoy, D. A. (1998). Bacterial delivery of DNA evolves [news; comment]. Nat Biotechnol 16: 138-9.

Thompson, R. J., Bouwer, H. G., Portnoy, D. A., and Frankel, F. R. (1998). Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth. Infect Immun 66:3552-61.

Welch, M. D., Rosenblatt, J., Skoble, J., Portnoy, D. A., and Mitchison, T. J. (1998). Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science 281:105-8.

Marquis, H., Goldfine, H., and Portnoy, D. A. (1997). Proteolytic pathways of activation and degradation of a bacterial phospholipase C during intracellular infection by Listeria monocytogenes. J Cell Biol 137:1381-92.

Smith, G. A., and Portnoy, D. A. (1997). How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force. Trends Microbiol 5:272-6.

Ikonomidis, G., Portnoy, D. A., Gerhard, W., and Paterson, Y. (1997). Influenza-specific immunity induced by recombinant Listeria monocytogenes vaccines. Vaccine 15:433-40.

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Smith, G. A., Theriot, J. A., and Portnoy, D. A. (1996). The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin. J Cell Biol 135:647-60.

Lee, K. D., Oh, Y. K., Portnoy, D. A., and Swanson, J. A. (1996). Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria monocytogenes. J Biol Chem 271:7249-52.

Jones, S., Preiter, K., and Portnoy, D. A. (1996). Conversion of an extracellular cytolysin into a phagosome-specific lysin which supports the growth of an intracellular pathogen. Mol Microbiol 21:1219-25.

Smith, G. A., Portnoy, D. A., and Theriot, J. A. (1995). Asymmetric distribution of the Listeria monocytogenes ActA protein is required and sufficient to direct actin-based motility. Mol Microbiol 17:945-51.

Marquis, H., Doshi, V., and Portnoy, D. A. (1995). The broad-range phospholipase C and a metalloprotease mediate listeriolysin O-independent escape of Listeria monocytogenes from a primary vacuole in human epithelial cells. Infect Immun 63:4531-4.

Smith, G. A., Marquis, H., Jones, S., Johnston, N. C., Portnoy, D. A., and Goldfine, H. (1995). The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread. Infect Immun 63:4231-7.

Moors, M. A., and Portnoy, D. A. (1995). Identification of bacterial genes that contribute to survival and growth in an intracellular environment. Trends Microbiol 3:83-5.

Freitag, N. E., and Portnoy, D. A. (1994). Dual promoters of the Listeria monocytogenes prfA transcriptional activator appear essential in vitro but are redundant in vivo. Mol Microbiol 12:845-53.

Jones, S., and Portnoy, D. A. (1994). Small plaque mutants. Methods Enzymol 236:526-31.

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Ikonomidis, G., Paterson, Y., Kos, F. J., and Portnoy, D. A. (1994). Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes. J Exp Med 180:2209-18.

Jones, S., and Portnoy, D. A. (1994). Characterization of Listeria monocytogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O. Infect Immun 62:5608-13.

Theriot, J. A., Rosenblatt, J., Portnoy, D. A., Goldschmidt-Clermont, P. J., and Mitchison, T. J. (1994). Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell 76: 505-17.

Portnoy, D. A., Smith, G. A., and Goldfine, H. (1994). Phospholipases C and the pathogenesis of Listeria. Braz J Med Biol Res 27:357-61.

Portnoy, D. A., and Jones, S. (1994). The cell biology of Listeria monocytogenes infection (escape from a vacuole). Ann N Y Acad Sci 730:15-25.

Marquis, H., Bouwer, H. G., Hinrichs, D. J., and Portnoy, D. A. (1993). Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants. Infect Immun 61:3756-60.

Freitag, N. E., Rong, L., and Portnoy, D. A. (1993). Regulation of the prfA transcriptional activator of Listeria monocytogenes: multiple promoter elements contribute to intracellular growth and cell-to-cell spread. Infect Immun 61:2537-44.

Smith, G. A., and Portnoy, D. A. (1993). The role of two phospholipases in the pathogenicity of Listeria monocytogenes. Infect Agents Dis 2:183-5.

Camilli, A., Tilney, L. G., and Portnoy, D. A. (1993). Dual roles of plcA in Listeria monocytogenes pathogenesis. Mol Microbiol 8:143-57.

Brundage, R. A., Smith, G. A., Camilli, A., Theriot, J. A., and Portnoy, D. A. (1993). Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells. Proc Natl Acad Sci U S A 90: 11890-4.

Portnoy, D. A., Chakraborty, T., Goebel, W., and Cossart, P. (1992). Molecular determinants of Listeria monocytogenes pathogenesis. Infect Immun 60:1263-7.

Portnoy, D. A., Tweten, R. K., Kehoe, M., and Bielecki, J. (1992). Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells. Infect Immun 60:2710-7.

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Bouwer, H. G., Nelson, C. S., Gibbins, B. L., Portnoy, D. A., and Hinrichs, D. J. (1992). Listeriolysin O is a target of the immune response to Listeria monocytogenes. J Exp Med 175:1467-71.

Freitag, N. E., Youngman, P., and Portnoy, D. A. (1992). Transcriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis. J Bacteriol 174:1293-8.

Barry, R. A., Bouwer, H. G., Portnoy, D. A., and Hinrichs, D. J. (1992). Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread. Infect Immun 60:1625-32.

Falkow, S., Isberg, R. R., and Portnoy, D. A. (1992). The interaction of bacteria with mammalian cells. Annu Rev Cell Biol 8:33-63.

Theriot, J. A., Mitchison, T. J., Tilney, L. G., and Portnoy, D. A. (1992). The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization. Nature 357:257-60.

Schafer, R., Portnoy, D. A., Brassell, S. A., and Paterson, Y. (1992). Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine. J Immunol 149:53-9.

Portnoy, D. A. (1992). Innate immunity to a facultative intracellular bacterial pathogen. Curr Opin Immunol 4: 20-4.

Camilli, A., Goldfine, H., and Portnoy, D. A. (1991). Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent. J Exp Med 173:751-4.

Camilli, A., Portnoy, A., and Youngman, P. (1990). Insertional mutagenesis of Listeria monocytogenes with a novel Tn917 derivative that allows direct cloning of DNA flanking transposon insertions. J Bacteriol 172:3738-44.

Tilney, L. G., Connelly, P. S., and Portnoy, D. A. (1990). Actin filament nucleation by the bacterial pathogen, Listeria monocytogenes. J Cell Biol 111:2979-88.

Brunt, L. M., Portnoy, D. A., and Unanue, E. R. (1990). Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth. J Immunol 145:3540-6.

Sun, A. N., Camilli, A., and Portnoy, D. A. (1990). Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread. Infect Immun 58:3770-8.

Dabiri, G. A., Sanger, J. M., Portnoy, D. A., and Southwick, F. S. (1990). Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly. Proc Natl Acad Sci U S A 87:6068-72.

Bielecki, J., Youngman, P., Connelly, P., and Portnoy, D. A. (1990). Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells. Nature 345:175-6.

Portnoy, D. A., Schreiber, R. D., Connelly, P., and Tilney, L. G. (1989). Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm. J Exp Med 170:2141-6.

Camilli, A., Paynton, C. R., and Portnoy, D. A. (1989). Intracellular methicillin selection of Listeria monocytogenes mutants unable to replicate in a macrophage cell line. Proc Natl Acad Sci U S A 86:5522-6.

Tilney, L. G., and Portnoy, D. A. (1989). Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes. J Cell Biol 109:1597-608.

Portnoy, D. A., Jacks, P. S., and Hinrichs, D. J. (1988). Role of hemolysin for the intracellular growth of Listeria monocytogenes. J Exp Med 167:1459-71.

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