The Portnoy Lab | UNIVERSITY OF CALIFORNIA, BERKELEY

*Listeria monocytogenes* mutant trapped in multilamellar body in a bone marrow macrophage.
*Listeria monocytogenes* infection: Actin (green), *Listeria monocytogenes* (red), DAPI (blue).
JEG3 cells infected with *Listeria monocytogenes* (green) and stained for LAMP1 (red), actin (teal), and DAPI (blue).
JEG3 cells infected with *Listeria monocytogenes* (green) and stained for LAMP1 (red), DAPI (blue), and phalloidin (yellow).
*Listeria monocytogenes* infection.

Sep

20

2018

New publication in Nature

By Neil Fischer

A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria. Light SH, Su L, Rivera-Lugo R, Cornejo JA, Louie A, Iavarone AT, Ajo-Franklin CM, Portnoy DA. Nature. 2018 Sep 12. doi: 10.1038/s41586-018-0498-z. [Epub ahead of print]. PMID: 30209391

Sep

12

2018

By Neil Fischer

Jul

23

2018

By Neil Fischer

Recombinant Listeria promotes tumor rejection by CD8⁺ T cell-dependent remodeling of the tumor microenvironment.
Deng W, Lira V, Hudson TE, Lemmens EE, Hanson WG, Flores R, Barajas G, Katibah GE, Desbien AL, Lauer P, Leong ML, Portnoy DA, Dubensky TW Jr.

Jun

13

2018

By Neil Fischer

The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection.
Chen C, Nguyen BN, Mitchell G, Margolis SR, Ma D, Portnoy DA. Cell Host Microbe 2018 Jun 13;23(6):786-795.e5. doi: 10.1016/j.chom.2018.05.006. PMID: 29902442

May

03

2018

By Neil Fischer

Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol. Cheng MI, Chen C, Engström P, Portnoy DA, Mitchell G. Cell Microbiol. 2018 Sep;20(9):e12854. doi: 10.1111/cmi.12854. Epub 2018 May 30. PMID: 29726107