Satoru Uzawa - Research Specialist

131 Koshland Hall
(510) 643-5583

Mailing Address:
University of California Berkeley
16 Barker Hall, MC 3204
Berkeley, CA 94720-3204









Research Summary
I'm the microscopist of the lab. I maintain various microscopes and train new users. As my own challenge, I'm trying to measure dynamics of various components of dosage compensation complex of C. elegans by microscopy.
Research Papers

Crane, E., Bian, Q., McCord, R.P., Lajoie, B.R., Wheeler, B. S., Ralston, E.J., Uzawa, S., Dekker, J., Meyer, B.J. (2015) Condensin-driven remodelling of X chromosome topology during dosage compensation. Nature, 1 June 2015 doi:10.1038/nature14450 [PDF]

Libuda, D., Uzawa, S., Meyer, B.J., Villeneuve, A. (2013) Meiotic chromosome structures constrain and respond to designation of crossover sites. Nature 502, 703-706 (31 October 2013) [PDF]

Shao L, Isaac B, Uzawa S, Agard DA, Sedat JW, Gustafsson MG. (2008). I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions. Biophys J. 94:4971-83

Jin Y, Mancuso JJ, Uzawa S, Cande WZ. (2005). The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification. Developmental Cell 9 (1): 63-73

Tatebe, H; Shimada, K; Uzawa, S; Morigasaki, S; Shiozaki, K (2005). Wsh3/Tea4 Is a Novel Cell-End Factor Essential for Bipolar Distribution of Tea1 and Protects Cell Polarity under Environmental Stress in S. pombe.    Curr Biol. 2005 15:1006-15.

Uzawa S., Li F, Jin Y, McDonald K, Braunfeld M, Agard D, Cande WZ.   (2004).   Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10 + .   Molecular Biology of the Cell 15:5219 -5230

Sagolla, Meredith, Satoru Uzawa, W Zacheus Cande.   (2003). Individual microtubule dynamics contribute to the function of mitotic and cytoplasmic arrays in fission yeast.   J. Cell Sci. 116: 4891-4903

Francesca Zolezzi, Jill Fuss, Satoru Uzawa, and Stuart Linn.   (2002).   Characterization of a Schizosaccharomyces pombe Strain Deleted for a Sequence Homologue of the Human Damaged DNA Binding 1 (DDB1) Gene.    J. Biol. Chem. 277: 41183-41191

Ye Jin, Satoru Uzawa, S and W. Zacheus Cande,. (2002).   Fission yeast mutants affecting telomere clustering and meiosis-specific spindle pole body integrity. Genetics. 160(3):861-876.

Pidoux, A. L., Uzawa, S., Perry, P., Cande, W. Z., and R. C. Allshire. (2000). Live analysis of lagging chromosome behaviour during anaphase and their effect on spindle elongation rate in fission yeast.   J. Cell Sci.   113:4177-4191.

Azuma, Y., Seino, H., Seki, T., Uzawa, S., Klebe, C., Ohba, T., Wittinghofer, A., Hayashi, N. and Nishimoto, T. (1996). Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran. J. Biochem. 120:82-01

Funabiki, H., Hagan, I., Uzawa, S. and Yanagida, M.   (1993)   Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast.   J. Cell Biol.   121: 961-976

Seino, H., Hisamoto, N., Uzawa, S., Sekiguchi, T. and Nishimoto, T.   (1992)   DNA-binding domain of RCC1 protein is not essential for coupling mitosis with DNA replication.   J. Cell. Sci.   102: 393-400

Uzawa, S. and Yanagida, M.   (1992)   Visualization of centromeric and nucleolar DNA in fission yeast by fluorescence in situ hybridization.   J. Cell Sci.   101: 267-275

Horio, T., Uzawa, S., Jung, M.K., Oakley, B.R., Tanaka, K. and Yanagida, M.   (1991)   The fission yeast g-tubulin gene is essential for mitosis and localized at microtubule organizing centers.   J. Cell Sci. 99: 693-700

Uzawa, S., Samejima, I., Hirano, T., Tanaka, K. and Yanagida, M. (1990)   The fission yeast cut1 + gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene.   Cell 62: 913-925

Uemura, T., Morino, K., Uzawa, S., Shiozaki, K. and Yanagida, M. (1987)   Cloning and sequencing of Schizosaccharomyces pombe DNA topoisomerase I gene, and effect of gene disruption.   Nuc. Acids Res.   15: 9727-9739

Review Papers

Nishimoto, T., Uzawa, S. and Schlegel, R.   (1992)   Mitotic checkpoints.   Curr. Opinions in Cell Biol.   4: 174-179

Horio, T., Uzawa, S. , Toda, T., Oakley, BR. and Yanagida, M. (1990). Isolation of microtubule regulating factors from fission yeast. Cell Struc. Func. 15:476

1986 - 1988
Kyoto University, Kyoto, Japan
Doctor of Philosophy in Biology

1980 - 1986
The International Christian University, Tokyo, Japan
Bachelor of Science in Biology