Katjuša Brejc - Research Specialist

131 Koshland Hall
(510) 643-5583
kbrejc@berkeley.edu

Mailing Address:
University of California Berkeley
16 Barker Hall, MC 3204
Berkeley, CA 94720-3204

 

 

 

 

 

 

 

 

Publications/Presentations

Malik FI, Hartman JJ, Elias KA, Morgan BP, Rodriguez H, Brejc K, Anderson RL, Sueoka SH, Lee KH, Finer JT, Sakowicz R, Baliga R, Cox DR, Garard M, Godinez G, Kawas R, Kraynack E, Lenzi D, Lu PP, Muci A, Niu C, Qian X, Pierce DW, Pokrovskii M, Suehiro I, Sylvester S, Tochimoto T, Valdez C, Wang W, Katori T, Kass DA, Shen YT, Vatner SF, Morgans DJ (2011).
Cardiac myosin activator: a potential therapeutic approach for systolic heart failure.
Science 331, 1439-1443.

Peters C, Brejc K, Belmont L, Bodey AJ, Lee Y, Yu M, Guo J, Sakowicz R, Hartman J, Moores CA. (2010).
Insight into the molecular mechanism of the multitasking kinesin-8 motor.
EMBO J 29, 3437-3447.

Wood KW, Lad L, Luo L, Qian X, Knight SD, Nevins N, Brejc K, Sutton D, Gilmartin AG, Chua PR, Desai R, Schauer SP, McNulty DE, Annan RS, Belmont LD, Garcia C, Lee Y, Diamond MA, Faucette LF, Giardiniere M, Zhang S, Sun CM, Vidal JD, Lichtsteiner S, Cornwell WD, Greshock JD, Wooster RF, Finer JT, Copeland RA, Huang PS, Morgans DJ Jr, Dhanak D, Bergnes G, Sakowicz R, Jackson JR (2010).
Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.
Proc. Natl. Acad. Sci. USA 107, 5839-5844.

Bergnes G, Brejc K & Belmont L (2005).
Mitotic Kinesins: Prospect for Antimitotic Drug Discovery.
Current Topics in Medicinal Chemistry 5, 127-145.

Celie PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB & Sixma TK (2004).
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.
Neuron 41, 907-914.

Smit AB, Brejc K, Syed NI & Sixma TK (2003).
Structure and function of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.
Ann NY Acad Sci 998, 81-92.

Brejc K, van Dijk WJ, Smit AB & Sixma TK (2002).
The 2.7A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.
Novartis Found Symp 245, 22-29.

Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL & Fuchs S (2001).
The binding site of acetylcholine receptor as visualized in the X-ray structure of a complex between α-bungarotoxin and a mimotope peptide.
Neuron 32, 265-275.

Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van der Oost J, Smit AB & Sixma TK (2001).
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.
Nature 411, 269-276.

Smit AB, Syed NI, Schaap D, Klumperman J, Kits KS, Lodder H, van der Schors RC, van Elk R, Sorgedrager B, Brejc K, Sixma TK & Geraerts WPM (2001).
A glia-derived acetylcholine-binding protein that modulates synaptic transmission.
Nature 411, 261-268.

Brejc K, Sixma TK, Kitts PA, Kain SR, Tsien RY, Ormö M & Remington SJ (1997).
Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.
Proc. Natl. Acad. Sci. USA 94, 2306-2311.

Brejc K, Ficner R, Huber R & Steinbacher S (1995).
Isolation, crystallization, crystal structure analysis and refinement of allophycocyanin from the cyanobacterium Spirulina platensis at 2.3 Å resolution.
J. Mol. Biol. 249, 424-440.

Previous Experience

2001-2008
Scientist
Cytokinetics, Inc., South San Francisco, CA

1996-2001
Post-doctoral work in Prof. Titia K. Sixma group
The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands

1992-1995
PhD work in Prof. Robert Huber group
Max-Planck Institute for Biochemistry, Martinsried, Germany

1987-1992
Dipl. Ing. Molecular Biology
University of Zagreb, Croatia

Education

1996-2001
Post-doctoral work in Prof. Titia K. Sixma group
The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands

1992-1995
Ph.D. work in Prof. Robert Huber group
Max-Planck Institute for Biochemistry, Martinsried, Germany

1987-1992
Dipl. Ing. Molecular Biology
University of Zagreb, Croatia